If Alzheimer’s is Type 3 Diabetes, Is This Fuel The Fix? | Dr Stephen Cunnane

Dr. Stephen Cunnane explains the "Brain Energy Gap", a documented metabolic shortfall and Alzheimer’s. Discover how ketones act as a vital "hybrid" backup fuel to keep brain cells alive. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Renue By Science* (10% off: MHS) https://tinyurl.com/ywpemydv - Skin Essentials - Collagen & Creatine *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Dr. Stephen Cunnane (Université de Sherbrooke) joins us to discuss his pioneering research on the "Brain Energy Gap"—a metabolic shortfall where the aging brain's ability to utilize glucose declines by 25% or more. This "double jeopardy" occurs when insulin resistance blocks both glucose uptake and the natural production of backup ketones. In this interview, we examine peer-reviewed PET imaging data using FDG and ketone tracers showing that while the brain’s glucose engine may fail in regions like the parietal cortex, the ketone engine remains functional and responsive to supply-driven intervention. Dr. Cunnane explains the Hybrid Brain model and how addressing this energy deficit may support cognitive healthspan. *MEDICAL DISCLAIMER*: This content is for educational purposes based on clinical research and does not constitute medical advice. Ketone supplements and MCTs should be used under professional supervision, especially for those with existing metabolic conditions. *RESEARCH NOTICE*: This discussion features Dr. Stephen Cunnane's work on brain energetics. The PET imaging discussed (FDG-PET) is a standard clinical tool used to observe the 25% decline in glucose utilization often seen in the parietal cortex during cognitive decline. 📚 Chapters 0:00 – Defining the "Brain Energy Gap" in Clinical Research 1:04 – The Hybrid Brain: Understanding Dual-Fuel Metabolism 1:53 – PET Imaging Evidence: Glucose vs. Ketone Uptake 5:33 – Metabolic Differences: Healthy Aging vs. Cognitive Decline 9:14 – The Science of Alternative Fuel Transporters in the Brain 12:27 – Insulin Resistance and the "Double Jeopardy" of Brain Starvation 🌐Links in this video Peer review research cited: Title: A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6‐month RCT Link : https://pmc.ncbi.nlm.nih.gov/articles/PMC8048678/ DOI: 10.1002/alz.12206 Title: Improved brain energetics and cognition after a 6-month ketogenic intervention in mild cognitive impairment: Final results of the Benefic Trial Link: https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.037961 DOI: 10.1002/alz.037961 Title: A reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE study Link: https://cdnsciencepub.com/doi/10.1139/apnm-2024-0277 DOI: 10.1139/apnm-2024-0277 #Longevity #BrainHealth #Alzheimers