Next-Gen Therapy Targets Zombie Cells Better Than Fisetin

Dr. Amit Sharma on what you can do now to support NK cell function plus the surprising science linking iron, ferroptosis and senescent cell survival. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Qualia* (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd Senolytic https://bit.ly/4jlaibe *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Dr. Amit Sharma is Group Leader in Senescence Immunology at the Lifespan Research Institute, where his lab studies how the immune system clears senescent cells and how that process can be supported or enhanced. In this fourth segment, Dr. Sharma gets practical, sharing what the current evidence suggests you can do to maintain your innate immune system's ability to clear senescent cells. The answer may be simpler than you expect, but the details matter. He also dives into the fascinating and still-evolving science of iron accumulation in senescent cells, explains why simply taking more or less iron may not be the answer, and shares his thoughts on quercetin, fisetin and dasatinib. Perhaps most intriguingly, he raises an open question that will make many longevity enthusiasts think twice: could taking antioxidant supplements actually help senescent cells survive? 🔬 Topics covered: - What you can do now to support NK cell and gamma delta T cell function - Sleep, exercise, caloric intake and their effect on immune senescence surveillance - Zinc and B12 — why deficiency matters more than supplementation - How to measure zinc levels and when supplementation makes sense - Why senescent cells accumulate iron — and what that means - Ferroptosis: the iron-dependent cell death that senescent cells resist - Why reducing dietary iron is unlikely to help - Quercetin, fisetin and dasatinib — what the evidence shows and what's still missing - New ferroptosis-targeting drugs as next-generation senolytics - Could antioxidant supplements increase senescent cell burden? An open question ▶️ This is Part 4 of my full interview with Dr. Sharma. Links to other segments below as they are 📚 Chapters 0:00 What can you do now to support your immune system? 1:15 Zinc; does supplementing actually help? 2:11 Why senescent cells accumulate iron 4:51 Should you worry about your iron levels? 5:49 Quercetin, fisetin and next-generation senolytics 🌐Links in this video Lifespan Research Institute: https://lifespanresearchinstitute.io Dr Sharma's lab page https://lifespan.io/our-research/sharma-lab/ #Senolytics #Longevity #Senescence