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AI Agents run my business and life (Andrew Wilkinson)

2026-05-04 Science & Technology
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Greg Isenberg
Greg Isenberg
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If you want more workflows and tactics to build a business with AI, check out this free workshop: https://www.ideabrowser.com/workshop I sit down with Andrew Wilkinson and we go deep on how he's restructured his work, his health, and his family office around AI agents. Andrew walks me through Deep Personality (an app he vibe-coded after running psychological screens on himself and his girlfriend), the autonomous SaaS business he runs through agent harnesses like Harbor, and the vector-database setup that lets him query Tiny and his personal holding company like an oracle. We cover where software is headed, why he's pouring capital into TSMC and data center stocks, and the daily AI workflows he's built around health, email triage, and a personalized morning podcast. Listeners walk away with concrete prompting tactics, agent architectures, and a frank read on where the moats are moving. Timestamps: 00:00 – Intro 01:50 – The OpenClaw and Claude Code Unlock 04:53 – Demo: Deep Personality App 10:38 – Harbor: An Agent Harness For Real Companies 12:30 – Autonomous Companies: Hype Vs. Reality 17:30 – Credibility As The Missing Layer For Vibe-Coded Products 20:14 – Centralizing Data Pipelines 21:35 – Vector Databases 23:22 – Transitioning Companies to Agentic Companies 25:22 – Where Andrew Would Build Today 27:10 – The New Interface 28:21 – Why build now 30:59 – Replacing Adapar: A Networth Wealth Platform 33:12 – Services As The New Software 35:29 – G-Brain Explained and Andrew’s OpenClaws 45:14 – Closing Thoughts Key Points * Andrew runs a SaaS business called Deep Personality almost entirely through agents, generating roughly $20K of revenue while debugging eats half his time. * Harbor (github.com/geekforbrains/Harbor) gives agents a GUI-style harness — dev, marketing, and support agents that can autonomously merge PRs and adjust ad budgets across PostHog, Meta, and Reddit. * Andrew's family office swapped headcount for a $40K/month Claude bill; his CFO, who had zero coding background, vibe-coded a replacement for Adapar (priced at $50K–$100K/year) in about two weeks. * Vector databases trained on Tiny and Andrew's holding company let him query 132 minority investments, P&Ls, and headcount data conversationally. * For builders today, Andrew suggests aiming for a $1M–$2M product, then parking gains in TSMC and data center exposure given how fast software moats are eroding. * His best prompting tip: ask the model to interview you with multiple-choice questions before generating any output. Numbered Section Summaries 1. The December 2025 Claude Code Unlock Andrew describes the moment Claude Code clicked for him — waking up at 3 or 4 a.m. with ten terminal tabs open, running an entire SaaS business from the back of Ubers in Arizona while traveling laptop-free. The hook is real, the productivity gain is real, and the debugging tax is also real. 2. Harbor And The Architecture Of Autonomous Operations We dig into Harbor, the agent harness his friend Gavin Vickery built. Marketing, dev, and support agents share a knowledge base, run multivariate ad tests, and auto-merge P0 security fixes. Andrew argues support as a job is months away from disappearing, while marketing agents will reshape what a $100K/month ad budget looks like. 3. The Reality Check On Autonomous Companies I push back on the autonomous-company narrative around products like Pulsia. Andrew agrees that today's agents resemble "Zapier zaps with intelligence" — capable but requiring step-by-step instruction like a genius baby. The unlock arrives when context windows reach 5–10 million tokens and a model can hold a whole company in mind. 4. Centralizing Context With G-Brain And Vector Databases Andrew has standardized on Claude Code as his operating system and routes Fireflies transcripts, emails, and meeting notes nightly into G-Brain (Gary Tan's vibe-coded vector database tool). Trained on his family office data, the system surfaces $16M invested → $36M current value across 132 deals; trained on Tiny, it acts as the "eye of Sauron" across 24 portfolio companies. The #1 tool to find startup ideas/trends - https://www.ideabrowser.com/ LCA helps Fortune 500s and fast-growing startups build their future - from Warner Music to Fortnite to Dropbox. We turn 'what if' into reality with AI, apps, and next-gen products https://latecheckout.agency/ The Vibe Marketer - Resources for people into vibe marketing/marketing with AI: https://www.thevibemarketer.com/ FIND ME ON SOCIAL X/Twitter: https://twitter.com/gregisenberg Instagram: https://instagram.com/gregisenberg/ LinkedIn: https://www.linkedin.com/in/gisenberg/ FIND ANDREW ON SOCIAL X/Twitter: https://x.com/awilkinson Deep Personality: https://deeppersonality.app/ Tiny: https://www.tiny.com/

Top Comments (10)

@kilosierraalpha 2026-05-04

Funny. I don't even watch your vids anymore. My agent just summarizes them and sends me one paragraph.

59 14 replies
@samuelramirez3914 2026-05-04

holy vibe slop how can you even put an app out on the market when the ui looks ike it was built on 5 prompts with opus 3.5

27 4 replies
@GregIsenberg 2026-05-04

i'll be in the comment section, i miss ya, come say hi/what you're thinking etc.

11 1 replies
@GavinVickery 2026-05-05

Thanks for the Harbour shoutout! Been a fun project✌🏻

5 1 replies
@BrightHorizonMusic 2026-05-04

nice having andrew on the pod, this was great. this should be a biweekly series since ai moves so fast

4 1 replies
@lbs 2026-05-04

It’s pretty inspiring to see that you can launch a vibe coded app with 0 design skills implemented and still make 20K+ on it. no shade intended as I think many of us would get hung up on that and would still be waiting to ship

4
@anandt2003 2026-05-04

Funny, my boss don't even watch these videos anymore. Me, his agent summarize it and he hears it while watching reels while I come here to comment on these videos. Good to see some humans here 👋

3
@RyanStephenAlldridge 2026-05-08

Long overdue AW episode! Let’s go Canadians. Great to see you both.

0
@AmitAujla20 2026-05-05

Real gem of a podcast with so much valuable learning from Andrew. I love listening to Andrew Wilkinson's podcast!

0
@IliaTalksAI 2026-05-04

So refreshing to hear someone, both of you, talking about the bs around fully autonomous companies. My openclaws need constant check ins, too. Thanks for being real!

0

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