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The Pat McAfee Show Picks & Predicts Every Game For NFL's 2025 Week 6 Weekend

2025-10-10 Sports
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The Pat McAfee Show
The Pat McAfee Show
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Weekly NFL Picks Analysis and Betting Insights

Gain expert opinions and analysis on every NFL matchup for the upcoming week to inform your betting strategies. Readers will see where the hosts agree and disagree on spread picks and identify potential schedule traps.

Short Summary

  • Hosts overwhelmingly favored the listed favorites in the early NFL slate (6 out of 6 initial picks).
  • Significant disagreement emerged on the Lions @ Chiefs matchup, where the small spread signaled a major underlying concern to the panel.
  • The Bengals received unanimous underdog support (+14.5) against the Packers, relying heavily on backup QB Joe Flacco.
  • The panel analyzes situational factors, including bye weeks, international travel, and noted historical coaching records across the slate.
  • This analysis provides bettors with the consensus and counterpoints for all major weekly matchups.

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Description

FULL PICKS AT THE END WE WILL PICK MONDAY NIGHT FOOTBALL ON MONDAY'S SHOW Picks 0:00 - 1:11 Broncos @ Jets In London 1:12 - 3:56 Browns @ Steelers 3:57 - 5:04 Cowboys @ Panthers 5:05 - 6:35 Chargers @ Dolphins 6:36 - 8:43 Patriots @ Saints 8:44 - 10:20 Rams @ Ravens 10:21 - 12:02 Seahawks @ Jaguars 12:03 - 12:39 Cardinals @ Colts 12:40 - 13:41 Titans @ Raiders 13:42 - 14:59 49ers @ Buccaneers 15:00 - 18:43 Bengals @ Packers 18:44 - 22:53 Lions @ Chiefs 22:54 - 23:00 Full Picks Welcome to The Pat McAfee Show LIVE from Noon-3PM EST Mon-Fri. You can also find us live on ESPN, ESPN+, & TikTok! Become a #McAfeeMafia member! https://www.youtube.com/channel/UCxcTeAKWJca6XyJ37_ZoKIQ/join SUBSCRIBE: https://www.youtube.com/channel/UCxcTeAKWJca6XyJ37_ZoKIQ?sub_confirmation=1 MERCH: https://store.patmcafeeshow.com Subscribe to the Pat McAfee Show(s)! @Hammer Dahn @The CONCAFA Show @The Pod @The Pat McAfee Show MERCH: https://store.patmcafeeshow.com SPONSOR THE SHOW: https://www.patmcafeeshow.com/partnerships #PatMcAfee #NFL

Top Comments (10)

@Rogue1sme 2025-10-10

I got Vikings over the Texans during the bye. I think Vikings are just more prepared for it.

266 25 replies
@Numenorean5393 2025-10-10

" DeShawn Watson looks healthy." My Brother he has had 5000 massages. He'd better look healthy.

141 5 replies
@darrentorpey2431 2025-10-10

PMS NFL Picks Week 6 Pat Eagles (-7) Lost by 17 ❌️ Broncos (-6.5) Won by 2 ❌️ Steelers (-5.5) Won by 14 ✅️ Cowboys (-3) Lost by 3 ❌️ Chargers (-3.5) Won by 2 ❌️ Patriots (-3.5) Won by 6 ✅️ Rams (-7) Won by 14 ✅️ Jags (+1.5) Lost by 8 ❌️ Colts (-6.5) Won by 4 ❌️ Titans (+4.5) Lost by 10 ❌️ 49ers (+3.5) Lost by 11 ❌️ Bengals (+14.5) Lost by 9 ✅️ Chiefs (-2.5) Won by 13 ✅️ Falcons (+3.5) Won by 10 ✅️ Bears (+5.5) Won by 1 ✅️ Record This Week 7-8. Record Last Week 9-5. Overall Record 42-50-1. Overall Head to Head 2-3-1. AJ Giants (+7.5) Won by 17 ✅️ Broncos (-6.5) Won by 2 ❌️ Steelers (-5.5) Won by 14 ✅️ Cowboys (-3) Lost by 3 ❌️ Chargers (-3.5) Won by 2 ❌️ Patriots (-3.5) Won by 6 ✅️ Rams (-7) Won by 14 ✅️ Jags (+1.5) Lost by 8 ❌️ Colts (-6.5) Won by 4 ❌️ Raiders (-3.5) Won by 10 ✅️ Bucs (-3) Won by 11 ✅️ Bengals (+14.5) Lost by 9 ✅️ Lions (+2.5) Lost by 13 ❌️ Bills (-3.5) Lost by 10 ❌️ Commanders (-5.5) Lost by 1 ❌️ Record This Week 7-8. Record Last Week 11-3. Overall Record 46-45-2. Overall Head to Head 3-2-1.

74 4 replies
@JaquelynPerez-i6b 2025-10-10

Most pickers have said the 49ers would lose every week but somehow they 4-1 without anyone 🤯

35 5 replies
@bobxiong4516 2025-10-10

CHARGERS vs DOLPHINS is gonna be a shootout. No RBs, no Def, no Olines, just guns all the way!

23 6 replies
@C.A.D. 2025-10-10

These videos always helpin with the last few hours of the work week

15
@adammcallister5773 2025-10-10

Connor’s bit on the Spencer Rattler was so funny😂

7
@gobleforrestfg 2025-10-10

Thanks for staying consistent boys!! A lot of us appreciate your efforts! Remember get it while the getting is good Boys need to start making merch

6
@grant9247 2025-10-10

The Bengals have so much salary cap space. They just need to use it

3
@Chargersgrimlin 2025-10-12

“Herbert has never beat the dolphins” talking out his ass right there lol😂😂😂

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