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Where the “DNA Is a Language” Analogy Breaks Down | Joshua Swamidass

2026-05-25 People & Blogs
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Closer To Truth
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*Can biology ever be fully reduced to chemistry and physics?* Joshua Swamidass argues that biology works through multiple levels of explanation, where analogies like “DNA is a language” can reveal important truths while also breaking down in surprising ways. 0:00 Molecular Biology and Human Analogy 1:29 The Limits of the DNA-as-Language Analogy 4:23 Parallel Processes in Molecular Biology 6:17 Reductionism and Emergence in Biology 8:50 Rules, Exceptions, and Evolutionary Dynamics S. Joshua Swamidass is an American computational biologist, physician, academic, and author. He is an associate professor of Laboratory and Genomic Medicine, and a Faculty Lead of Translational Bioinformatics in the Institute for Informatics at Washington University in St. Louis. *More from James Tabor on Closer To Truth:* * Website: https://closertotruth.com/contributor/joshua-swamidass/ *Subscribe to Closer To Truth:* https://www.youtube.com/@CloserToTruthTV *Join the Community:* * Membership (5,000+ videos): https://closertotruth.com/register/ * Audio Podcast: https://closertotruth.podbean.com * Support the Show: https://closertotruth.com/donate/ * Official Merchandise: https://www.bonfire.com/store/closertotruth/ *Follow Us:* * Facebook: https://www.facebook.com/CloserToTruthTV/ * Instagram: https://www.instagram.com/closertotruth/ * X: https://x.com/CloserToTruth Closer To Truth, hosted by Robert Lawrence Kuhn and directed by Peter Getzels, presents the world’s greatest thinkers exploring humanity’s deepest questions. Discover fundamental issues of existence. Engage new and diverse ways of thinking. Appreciate intense debates. Share your own opinions. Seek your own answers. #CloserToTruth #Meaning #JoshuaSwamidass #PhilosophyOfBiology #MolecularBiology

Top Comments (10)

@CloserToTruthTV 2026-05-25

Joshua Swamidass argues that molecular biology depends on multiple levels of abstraction, where analogies can illuminate biological systems without fully reducing them to chemistry or physics. Do biological systems ultimately reduce to lower-level physical laws, or do higher levels of organization introduce genuinely new ways of understanding nature?

3 3 replies
@patientson 2026-05-25

Joshua Swamidass, you are a joker.

2
@Maxwell-mv9rx 2026-05-25

He doesnt explains his experiences; instead he uses a lot rethoric. This cannot be the way to understand this issue.

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@johnhoey7717 2026-05-25

DNA isn’t simply information organized into a “language.” It’s actually specified information organized into a language that is more complex than any language we’ve ever identified.

1 2 replies
@newtonfinn164 2026-05-25

So the molecular world is as strange and weird as the quantum world, where the best our minds can do to grok them is to come up with crude analogies. The name of the old god was Evolution. The new god is named Emergence. Is not analogy the essence of theology, whether religious or secular, defined as our attempt to describe the fire in the equations?

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@MarkPatmos 2026-05-25

Interesting different levels of reductionist biology don't relate easily to each other. A bit like Quantum Mechanics and classical physics?

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@mulen-x8u 2026-05-25

I think "molecular biology" is the lower level or boundary between living and nonliving matter. If DNA is a kind of language with its own grammatical and logical structure, then life may be a kind of energy or creative force that gives language meaning. The letter of the law without the spirit of the law is dead, or the written Bible without the spoken Bible is incomplete and lifeless.

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@MarkPatmos 2026-05-26

We are all just mutated lumps of matter

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@sanjeevjain5519 2026-05-25

DNA, RNA, and proteins are all information-dense constituents of a cell. In fact, the total functioning of the cell is information-based. This algorithm for the functioning of a cell and cell collectives is stored in the soul. In fact, soul is necessary for biology.

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@infinitelyexhausted 2026-05-26

This feels like he's missing the point (maybe I am?). People are not saying DNA is like a human language - they're saying it is more like a computer programming language. Either way, it is a coding that allows for communication / building upon.

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