The Future of Senolytics: Is Rejuvenation Only 5 Years Away?

Dr. Amit Sharma on the future of senotherapy, the link between senescent cells and cancer, and how important clearing senescent cells really is for healthspan. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Qualia* (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd Senolytic https://bit.ly/4jlaibe *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Dr. Amit Sharma is Group Leader in Senescence Immunology at the Lifespan Research Institute, where his lab is working to understand and therapeutically target senescent cells using both immune-based and small molecule approaches. In this final segment, Dr. Sharma looks at the bigger picture — where senotherapy is headed, what timeline we might expect for clinical therapies, and how important removing senescent cells really is for healthspan and lifespan. He also reveals a fascinating biological overlap between senescent cells and cancer cells, explaining why the two fields of research are more connected than most people realise. He closes with an honest assessment of what we still don't know — including the critical challenge of distinguishing good senescent cells from bad ones — and why finding a common vulnerability across all senescent cell types could be the key that unlocks truly effective therapy. 🔬 Topics covered: - The future of senotherapy — first and next generation senolytics - Innate immune cell therapies for aging diseases — where the field is heading - Timeline to the clinic — what Dr. Sharma is excited about in the next 5–10 years - The surprising biological overlap between senescent cells and cancer cells - How gamma delta T cell research grew out of cancer immunology - How important is removing senescent cells for healthspan? What the animal data shows - Good vs bad senescent cells — why selective targeting matters - The search for a common vulnerability across all senescent cell types - What still needs to be solved before senotherapy reaches its potential ▶️ This is the final part of my interview with Dr. Amit Sharma. Links to all other segments below. 📚 Chapters 0:00 The future of senotherapy; what's coming next 2:20 Senescent cells and cancer; a surprising overlap 4:11 How important is clearing senescent cells for healthspan? 7:43 The search for a common senescent cell vulnerability 8:32 What would truly effective senotherapy look like? 🌐Links in this video Lifespan Research Institute: https://lifespanresearchinstitute.io Dr Sharma's lab page https://lifespan.io/our-research/sharma-lab/ #Senolytics #Longevity #Senescence