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Top Chemist Just Discovered How to Hack the Brains Internal DMT Molecule | Chris McCurdy

2025-10-27 Entertainment
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Danny Jones
Danny Jones
1.2m subscribers

Researching Endogenous DMT, Kratom Chemistry, and Natural Product Potential

Discover the cutting-edge research defining how natural molecules regulate powerful compounds like DMT and how this impacts understanding major conditions like schizophrenia and opioid addiction.

Short Summary

  • Research is actively searching for the natural peptide inhibitor of endogenous DMT synthesis, which could revolutionize schizophrenia treatment.
  • The complex pharmacology of Kratom is broken down, highlighting the difference between the whole leaf (mild risk) and concentrated 7-OH extracts (pure opioid activity).
  • Discussions covered the mind’s power via Transcendental Meditation and the lethal nature of withdrawal from common substances like alcohol versus milder botanical withdrawal.
  • This session details medicinal chemistry principles used to inspire the next generation of safer, effective synthetic drugs based on nature’s blueprint.

Dr. Chris McCurdy, a pharmaceutical scientist, shares his extensive background in drug architecture and natural products research. We explore his current project targeting endogenous DMT synthesis to treat psychological disorders, alongside a detailed analysis of the safety profile and complexity of widely used botanicals like Kratom and Coca leaf.

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Description

Watch every episode ad-free & uncensored on Patreon: https://patreon.com/dannyjones Chris McCurdy is a pharmaceutical scientist and pharmacist whose research focuses on the design, synthesis and development of drugs to treat pain and drug abuse. His latest research investigates a naturally occurring molecule that may regulate an enzyme which helps produce the powerful psychedelic compound dimethyltryptamine, or DMT, in the body. SPONSORS https://expressvpn.com/dannyjones - Get up to 4 extra months free. https://mnniceethno.com/dj - Use code DJ22 for 22% off your first order. https://ver.so/danny - Use code DANNY for 15% off your order. https://whiterabbitenergy.com/?ref=DJP - Use code DJP for 20% off EPISODE LINKS https://pharmacy.ufl.edu/profile/mccurdy-christopher https://pubmed.ncbi.nlm.nih.gov/?term=McCurdy+CR&cauthor_id=33213215 FOLLOW DANNY JONES https://www.instagram.com/dannyjones https://twitter.com/jonesdanny LISTEN ON Spotify - https://open.spotify.com/show/4VTLG0HiIZaCjH9gE6NFPq Apple - https://itunes.apple.com/podcast/id1441238966 OUTLINE 00:00 - The most hallucinogenic plant in existence 09:39 - Natural DMT in our bodies & schizophrenia 19:43 - Finding DMT in spinal fluid 27:06 - Endogenous tripping & transcendental meditation 37:26 - Placebo effect & treating cancer with the brain 47:08 - The flaw in the "healthcare equation" 57:18 - Why coca leaves should be legal 01:13:44 - Only 3 countries where coca leaves are legal 01:17:18 - Kratom's dangerous trajectory 01:29:15 - World's biggest kratom study 01:43:01 - 7 hydroxy products (7-OH) vs. kratom 01:47:12 - The drug with the deadliest withdrawal process 01:59:52 - Why ritalin shouldn't be prescribed to kids 02:07:46 - How Modafinil works 02:14:55 - The kanna plant 02:20:02 - FDA finds how much kratom leads to overdose 02:28:12 - Different strains of kratom leaf

Top Comments (10)

@wiskatesnow 2025-10-27

This guy is a great guest. He's very grounded, scientific, and understated, but realizes the power of exploring states of consciousness. He's also very likable, calm, and easy to listen to.

115 3 replies
@Mong00se22 2025-10-27

Balancing moods and pain would fix a multitude of societies problems. This guy is more important than we think.

71 12 replies
@tylerdavis8834 2025-10-27

Guys like this in these little niche fields of study can often times change the world. Very interesting dude

68 6 replies
@dannyjones 2025-10-27

Watch every episode ad-free & uncensored on Patreon: https://patreon.com/dannyjones Support the show by checking out our sponsors: https://expressvpn.com/dannyjones - Get up to 4 extra months free. https://mnniceethno.com/dj - Use code DJ22 for 22% off your first order. https://ver.so/danny - Use code DANNY for 15% off your order. https://whiterabbitenergy.com/?ref=DJP - Use code DJP for 20% off

24 8 replies
@amberbrooks82 2025-11-11

I was addicted to pain pills years ago, and kraton helped me quit. I honestly don't know if I could've done it without. This guy is awesome 👍

11 1 replies
@lcarthel 2025-11-03

DMT is a rocket ride, in and out of the brain fast but has zero addiction potential

7
@ianzuniga1921 2025-11-07

We require you bring this guy every 12 months to give us an update, please!

7
@marcuswaterloo 2025-11-30

The fear is a horrendous effect of opioid withdrawal, the idea you can have fear of nothing is wild.

4 1 replies
@t0kigh02t7 2025-11-11

This is seriously the most interesting topics and guests on YouTube.

2
@ryanwilliams9644 2025-11-03

One good thing host said was isn't the trip the best part of it ?

2

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