Joscha Bach: Why We Still Can't Simulate a Worm's Brain
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Top Comments (10)
A worm with 302 neurons. Mapped completely since 1986. *Forty years later, no simulation can reproduce its behavior.* If we can't get a worm out of perfect wiring data, what does that say about every plan to upload a human brain? *Watch the clip and tell me where Joscha is wrong.* Full 90m convo coming soon!
Basically we don't know nearly as much as we proclaim to know.
Sounds remarkable interesting. Waiting for the whole thing with Josha bach.
This is the most insightful thing I have heard from Joscha Bach. He is right that the “hardware” of animal nervous systems is grossly over-simplified when it’s assumed to fit the digital computer paradigm.
Not only can we not deterministically model a cell, we can’t deterministically model a single sodium channel.
It is my understanding that the fruit fly connectome made the fruit fly behave more like a fruit fly than an LLM generated software for fruit fly behavior. The odd thing is that the C Elegans connectome ran the fruit fly behavior the same as the fruit fly connectome. Like chasing zebras in strobe lighting
This study about how a caterpillar's brain is liquefied during metamorphosis, and later re-built while preserving memories, has me blown away. That is insane. Man, we still have so much to learn about nature.
It's all computers but algorithms don't accumulate.
"Deep in the human unconscious is a pervasive need for a logical universe that makes sense. But the real universe is always one step beyond logic."-Frank Herbert
While many larval neurons die off, some of the specific connections formed in the mushroom bodies during the caterpillar stage are preserved and integrated into the more complex adult brain.
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Top Comments (10)
A worm with 302 neurons. Mapped completely since 1986. *Forty years later, no simulation can reproduce its behavior.* If we can't get a worm out of perfect wiring data, what does that say about every plan to upload a human brain? *Watch the clip and tell me where Joscha is wrong.* Full 90m convo coming soon!
Basically we don't know nearly as much as we proclaim to know.
Sounds remarkable interesting. Waiting for the whole thing with Josha bach.
This is the most insightful thing I have heard from Joscha Bach. He is right that the “hardware” of animal nervous systems is grossly over-simplified when it’s assumed to fit the digital computer paradigm.
Not only can we not deterministically model a cell, we can’t deterministically model a single sodium channel.
It is my understanding that the fruit fly connectome made the fruit fly behave more like a fruit fly than an LLM generated software for fruit fly behavior. The odd thing is that the C Elegans connectome ran the fruit fly behavior the same as the fruit fly connectome. Like chasing zebras in strobe lighting
This study about how a caterpillar's brain is liquefied during metamorphosis, and later re-built while preserving memories, has me blown away. That is insane. Man, we still have so much to learn about nature.
It's all computers but algorithms don't accumulate.
"Deep in the human unconscious is a pervasive need for a logical universe that makes sense. But the real universe is always one step beyond logic."-Frank Herbert
While many larval neurons die off, some of the specific connections formed in the mushroom bodies during the caterpillar stage are preserved and integrated into the more complex adult brain.