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Nancy Guthrie search | Expert: Suspect likely left saliva DNA | Truth of the Matter

2026-03-14 News & Politics
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Description

An 84-year-old woman disappears from her home, blood found on the doorstep. Foreign DNA is discovered inside the house, but it’s a mixed sample. And more than a month later, investigators still don’t have a suspect. In this episode of “The Truth of the Matter Podcast,” Natasha Zouves sits down with one of the most prominent genetic genealogists in the world, CeCe Moore, the forensic expert who has helped solve more than 300 cases using DNA. Moore breaks down what investigators are really dealing with in the Nancy Guthrie disappearance, and why the DNA evidence may be far more complicated than the public realizes. Among the revelations in this interview: • Moore believes the technology needed to separate the mixed DNA sample may not exist yet • Why police cannot simply search the largest 23andMe or Ancestry databases • The loophole investigators used in the Bryan Kohberger / Idaho murders case that no longer exists • Why Moore believes investigators should re-swab the Guthrie home right now • And why she believes the case could turn on the discovery of a second crime scene Investigative genetic genealogy helped identify the Golden State Killer and helped lead police to Bryan Kohberger in the Idaho student murders. Moore believes genetic genealogy will solve this case — and talks about the path to get there. #Crime #NancyGuthrie #PimaCounty #NancyGuthrieCase #SavannahGuthrie #TrueCrime #TrueCrimeNews #MissingPerson #UnsolvedCase #CrimeInvestigation #DNAEvidence #GeneticGenealogy #ForensicScience #DNAInvestigation #ColdCase #ColdCaseFiles #CrimeAnalysis #InvestigativeJournalism #CrimePodcast #TheTruthOfTheMatter #CeCeMoore #BryanKohberger #IdahoMurders #GoldenStateKiller The Truth of the Matter with Natasha Zouves isn’t just another podcast; it’s a fight to uncover what powerful institutions want hidden. From secret human experiments the government carried out on unsuspecting citizens to toxic cover-ups poisoning communities, Emmy and Murrow Award-winning journalist Natasha Zouves brings you the stories people in power don’t want told. We expose evidence buried in archives, amplify the voices of those who’ve been silenced, and hold the powerful accountable. From radioactive “oatmeal experiments” on children, to cancer-causing chemicals destroying farms, to veterans erased from history — these are the stories that matter. This is journalism that refuses to look away. The Truth of the Matter is about transparency and justice for the people left behind. RELATED MUST-WATCH CONTENT: Nancy Guthrie search: Case cooling, search theories, Savannah Guthrie's 'Today' return | Backscroll: https://www.youtube.com/watch?v=_Jds4GA4NTo Missing: The Nancy Guthrie Mystery complete special: https://www.youtube.com/watch?v=AgXGizimhGI DNA samples in Nancy Guthrie case are ‘mixed’: Sheriff | NewsNation Prime: https://www.youtube.com/watch?v=M6i5PHOcj90 Follow the podcast on Instagram: https://www.instagram.com/truthofthematterpod/ Find host Natasha Zouves: https://www.instagram.com/natashazouves/ https://www.tiktok.com/@natashazouves https://www.facebook.com/natashanzouves/ You can find “The Truth of the Matter” wherever you listen to your podcasts: https://podcasts.apple.com/us/podcast/the-truth-of-the-matter-with-natasha-zouves/id1804707066 https://open.spotify.com/show/2iQ85VHlMmBfLBaTtSp8tF This podcast is put together by: Ryan Kerr Allie Purser Mia Balbin-Cuesta Kate Linderman Richard Bodee Natasha Zouves Edited by: Maria Morales Salazar NewsNation is your source for fact-based, unbiased news for all America. More from NewsNation: https://www.newsnationnow.com/ Get our app: https://trib.al/TBXgYpp Find us on cable: https://trib.al/YDOpGyG How to watch on TV or streaming: https://trib.al/Vu0Ikij Chapters: 00:00:00 – 00:01:58: A chilling mystery: where is Nancy Guthrie? 00:01:59 – 00:21:06: Does genetic genealogy hold the key to cracking open this mystery? 00:21:07 – 00:30:54: How genetic genealogy solved the Idaho student murders 00:30:55 – 00:37:04: The limitations of genetic genealogy 00:37:05 - 00:47:27: What are the implications for genetic genealogy if Nancy Guthrie’s disappearance was cartel-related? 00:47:28 – 00:49:35: What can people do if they want to help genetic genealogists? 00:49:36 – END Cece Moore’s take on the Nancy Guthrie case

Top Comments (10)

@PositiveChi 2026-03-15

Wow this guest is so informative on this subject.

36 6 replies
@SueBoo2 2026-03-15

Such an educated young lady! Respect 🫡

32 1 replies
@jessicafaithgold1928 2026-03-15

Mannnn, I would love to be in college, Grad School, PhD program; the whole shebang!I love all of the intricate details and new tech, advances in working with DNA… I would love to work with a team to get it done!!!!Solve more crimes, like, how awesome do these ppl feel when they are part of the investigation team that led to the right perp and nail their asses??? Those who help solve cases like what they cited are so freaking amazing! FR! FR!!! You are giving the victim dignity and grace, you’re helping families of murder victims learn who, why, what…! Essential workers!!!I appreciate yall so much!

31 4 replies
@rbevans4648 2026-03-15

Excellent explanations of complex DNA technology; learned a lot. Thanks.

31 2 replies
@katherinefitzpatrick446 2026-03-15

Thank you so much for this long-form interview with CeCe. And you did ask excellent questions. Thank you!

30
@suem.3651 2026-03-15

This plus Brian Entin’s interview in the DNA TESTING LAB were fascinating and explain a lot. Thank you!!

24 1 replies
@jodilawler4956 2026-03-15

This is such a sad story! It's amazing what people do to each other! Depravity plain and simple! I pray that Nancy comes home!

23 1 replies
@truthspeaker711 2026-03-15

Great interview questions. Great job Natasha!

15
@Mamaseves 2026-03-15

Thank you Ms. Moore for pointing out the intricacies of adoption. As an adult adoptee I appreciate your acknowledgement of the difficulties in the genetic aspect of relinquishment and adoption.

8
@Susan-s3b 2026-03-15

If you hear screaming take a picture of the license plate and the car

5

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