The Pat McAfee Show Picks & Predicts Every Game For NFL's 2025 Week 1 Weekend
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Expert NFL Week 1 Point Spread Predictions and Analysis
Get definitive Week 1 NFL betting picks and critical early injury analysis, leveraging host consensus and expert insider reports to navigate the opening slate.
Short Summary
- Achieve a 100% success rate on preliminary (TNF) analysis, validating strong confidence entering the main slate.
- Address major risks, specifically the Christian McCaffrey (CMC) calf scare, based on insider reporting from Adam Schefter.
- Finalize spread picks across all 16 matchups, highlighting areas where public betting sentiment creates contrarian opportunities (e.g., Colts, Lions).
This document organizes the full slate of NFL Week 1 predictions delivered live. We break down spreads, discuss major personnel news like the CMC calf report, and establish clear leans for each contest. Use these picks to inform your opening weekend decisions and anticipate potential upsets.
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Top Comments (10)
“Chiefs easy” lmaoo
Someone needs to track their picks. They were not even close last year
Here after the Chargers win, gosh that felt amazing!
Gotta love the 49ers vs Seahawks segment being 50% about CMC and the 9ers, 49% about Iowa St(?), and 1% about the hawks. Come on now lol
PMS NFL Picks Week 1 Pat Cowboys (+8.5) Lost by 4 ✅️ Chiefs (-3) Lost by 6 ❌️ Raiders (+2.5) Won by 7 ✅️ Steelers (-2.5) Won by 2 ❌️ Colts (-0.5) Won by 25 ✅️ Browns (+5.5) Lost by 1 ✅️ Giants (+6) Lost by 18 ❌️ Jags (-3.5) Won by 16 ✅️ Bucs (-1.5) Won by 3 ✅️ Cardinals (-6.5) Won by 7 ✅️ 49ers (-1.5) Won by 4 ✅️ Broncos (-8) Won by 8 ➖️ Lions (+2.5) Lost by 14 ❌️ Rams (-3) Won by 5 ✅️ Ravens (-1) Lost by 1 ❌️ Vikings (-1.5) Won by 3 ✅️ Record this week 10-5. Overall Record 10-5-1. Overall Head to Head 1-0. AJ Cowboys (+8.5) Lost by 4 ✅️ Chiefs (-3) Lost by 6 ❌️ Patriots (-2.5) Lost by 7 ❌️ Steelers (-2.5) Won by 2 ❌️ Colts (-0.5) Won by 25 ✅️ Bengals (-5) Won by 1 ❌️ Giants (+6) Lost by 18 ❌️ Jags (-3.5) Won by 16 ✅️ Bucs (-1.5) Won by 3 ✅️ Saints (+6.5) Lost by 7 ❌️ 49ers (-1.5) Won by 4 ✅️ Broncos (-8) Won by 8 ➖️ Packers (-1.5) Won by 14 ✅️ Texans (+3.5) Lost by 5 ❌️ Bills (+1.5) Won by 1 ✅️ Vikings (-1.5) Won by 3 ✅️ Record this week 8-7-1. Overall Record 8-7-1. Overall Head to Head 0-1.
Pat just realizing adam shafter really adds nothing?
BEST segment every year. Love it. Only addition I would love to see is seeing AJ and Pat's face be placed next to each of their selections after they say their picks.
Just watching this, and after hearing 2:30 “Chiefs, easy.” Lol.. loved the confidence though.
What a game from Justin Herbert! What a difference from Staley to Harbaugh! Now when the Chiefs landed a shot the Chargers were able to answer! What a game!
"Chiefs easy" aged like Milk😂
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Top Comments (10)
“Chiefs easy” lmaoo
Someone needs to track their picks. They were not even close last year
Here after the Chargers win, gosh that felt amazing!
Gotta love the 49ers vs Seahawks segment being 50% about CMC and the 9ers, 49% about Iowa St(?), and 1% about the hawks. Come on now lol
PMS NFL Picks Week 1 Pat Cowboys (+8.5) Lost by 4 ✅️ Chiefs (-3) Lost by 6 ❌️ Raiders (+2.5) Won by 7 ✅️ Steelers (-2.5) Won by 2 ❌️ Colts (-0.5) Won by 25 ✅️ Browns (+5.5) Lost by 1 ✅️ Giants (+6) Lost by 18 ❌️ Jags (-3.5) Won by 16 ✅️ Bucs (-1.5) Won by 3 ✅️ Cardinals (-6.5) Won by 7 ✅️ 49ers (-1.5) Won by 4 ✅️ Broncos (-8) Won by 8 ➖️ Lions (+2.5) Lost by 14 ❌️ Rams (-3) Won by 5 ✅️ Ravens (-1) Lost by 1 ❌️ Vikings (-1.5) Won by 3 ✅️ Record this week 10-5. Overall Record 10-5-1. Overall Head to Head 1-0. AJ Cowboys (+8.5) Lost by 4 ✅️ Chiefs (-3) Lost by 6 ❌️ Patriots (-2.5) Lost by 7 ❌️ Steelers (-2.5) Won by 2 ❌️ Colts (-0.5) Won by 25 ✅️ Bengals (-5) Won by 1 ❌️ Giants (+6) Lost by 18 ❌️ Jags (-3.5) Won by 16 ✅️ Bucs (-1.5) Won by 3 ✅️ Saints (+6.5) Lost by 7 ❌️ 49ers (-1.5) Won by 4 ✅️ Broncos (-8) Won by 8 ➖️ Packers (-1.5) Won by 14 ✅️ Texans (+3.5) Lost by 5 ❌️ Bills (+1.5) Won by 1 ✅️ Vikings (-1.5) Won by 3 ✅️ Record this week 8-7-1. Overall Record 8-7-1. Overall Head to Head 0-1.
Pat just realizing adam shafter really adds nothing?
BEST segment every year. Love it. Only addition I would love to see is seeing AJ and Pat's face be placed next to each of their selections after they say their picks.
Just watching this, and after hearing 2:30 “Chiefs, easy.” Lol.. loved the confidence though.
What a game from Justin Herbert! What a difference from Staley to Harbaugh! Now when the Chiefs landed a shot the Chargers were able to answer! What a game!
"Chiefs easy" aged like Milk😂