Bizarre Structures Inside Blood May Be Responsible for Long COVID
Discovery of Persistent Microclots and NETs in Long COVID Blood
Understand the latest research identifying structural abnormalities—sticky microclots stabilized by immune system remnants—that may reveal diagnostic markers and treatment targets for Long COVID.
Short Summary
- Scientists found dramatically increased, persistent microclots stabilized by Neutrophil Extracellular Traps (NETs) in Long COVID patients.
- This structural link offers high accuracy (nearly 91%) for blood-based diagnostic potential.
- Targeting these specific net-based microclot complexes represents a potential roadmap for future Long COVID therapies. This segment details the potential underlying mechanism fueling chronic Long COVID symptoms: abnormal clotting caused by persistent protein structures trapped within the bloodstream. This research provides an objective signal absent in current symptom-based diagnoses.
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Top Comments (10)
@Physics Girl has been dealing with this since her infection. I eagerly look forward to Dianna getting better and overcoming this awful condition. Her husband is a true hero in all of this. Including documenting occasionally what they are going through. I hope this finds them both a little comfort to know their fans are still out here.
I hope they're comparing the people with vaccination vs those without.Those results would be beyond interesting....
I got COVID and it took me out big time. Never known anything like it and at the time genuinely thought my time was up on this world. Took the Astra Zeneca vaccine three times then stopped. That was around 5 years ago. I used to be a physical training instructor back then. I'm now experiencing chronic fatigue, severe sharp pain in my chest and inside the top of my right leg and constant pressure in my head. All these symptoms get much worst when I lie down. I lost my job, my partner left me and I've suffered from depression as a result of all this. I've always known something went wrong after COVID. It's good to finally see the reason why. I don't have much hope that I'll get a cure anytime soon but thanks for this. It's a relief of a sort. Edit: I'm not obese. I force myself to walk everyday and sometimes even manage a slow jog. I eat a balanced diet too and try and sleep best I can even though it's painful to do I wake up constantly with the feeling of suffocation.
Remember when morticians started talking about clots they're finding in the corpses they're embalming, and they were labelled "conspiracy theorists" for it? I do.
I'm a mother and carer of a sufferer of ME/CFS of some years. (Struck after a flu-like illness pre-covid.) I would like presenters (even the wonderful Anton) and viewers to stop conflating the notion of "tiredness" with fatigue. It has a strong tendency to minimise the global consequences of severe fatigue leading to misunderstanding, sometimes trivialising, of its effects across the entire body-mind, every single physiological system, every cell, every organ. It is not a worse form of tiredness the rest of us recognise, it is far more pervasive, and devastating. It does not improve with rest nor with exercise. Always good to see progress in research, each piece of the puzzle is valuable. This is how a cure will eventually be found. Thanks Anton!
I’m really excited about long COVID research because it’s so similar to my autoimmune disease. I’ve had it for 24 years and Rheumatologists keep switching what they call it.
I've had chronic fatigue syndrome for 32 years, from back when medical people were sarcastically calling it "yuppie flu". I wasn't a yuppie, I was a 17 yr old who'd been hospitalized with mono (Epstein Barr Virus) because it was so bad they thought my spleen might need to come out. It was swollen to the rupture point. Nurses wrapped me in foam padding, and I had to ring for help if I wanted to roll over. I slept as much as 20 hrs a day for 4 weeks. They said they'd never seen someone hit so hard by EBV. I was so weak that I needed 2 years of physical/vocational rehab to drive a car and stay upright in the daytime. Still, nobody believed me that I felt so exhausted, it was as if the infection had never truly gone. Doctors called it neurotic, dependent needs for affection and attention when I kept coming to them for answers about the pervasive lethargy and relapsing symptoms (the thing I couldn't understand their dismissive attitude about most) like my constantly swelling/shrinking spleen. My family called me a na'er-do-well, my husband called me a drama addicted burden, doctors called me a neurotic liar. But here came long COVID, and there's so many people suffering various degrees of debilitation, from persistent crushing fatigue with vague symptoms that come and go, to full on relapses of the acute illness, that we can't all be liars, so here we are, researching and finding things like little foreign structures in blood. I'm pushing 50 now and it hardly matters to me. I pace myself as a homemaker and do what I can do each day. My kids are grown. The times when I had dreams for a career and a life full of pursuits are gone. I hardly care what happens, except I'm very happy the younger people, like PhysicsGirl, might have a chance at a real life. They don't deserve this. None of us do. The medical establishment can kiss my a$$. If they'd lifted a finger for people like me when we were begging for help, the virology might have been in place to prevent anyone from suffering so much from COVID.
From a medical professional standpoint, the multitude of widely different symptoms absolutely screams that it's a vascular problem, which could readily effect multiple organs and systems throughout the body, and with a wide variety of presentations. So microclots and possibly associated vasculitis are very strong contenders for the main cause of long COVID.
This hits hard...Ive never been the same since 2021,when I had my first infection with delta variant. Brain fog and cognitive problems being the main incapacitation. It was hell. Every test came back normal, I didnt know what was going on and the impact it had on me was awful. I was 18 back then...Thank you so much Anton for bringing light to this topic!!
Your channel doesn't get enough praise, thank you
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Top Comments (10)
@Physics Girl has been dealing with this since her infection. I eagerly look forward to Dianna getting better and overcoming this awful condition. Her husband is a true hero in all of this. Including documenting occasionally what they are going through. I hope this finds them both a little comfort to know their fans are still out here.
I hope they're comparing the people with vaccination vs those without.Those results would be beyond interesting....
I got COVID and it took me out big time. Never known anything like it and at the time genuinely thought my time was up on this world. Took the Astra Zeneca vaccine three times then stopped. That was around 5 years ago. I used to be a physical training instructor back then. I'm now experiencing chronic fatigue, severe sharp pain in my chest and inside the top of my right leg and constant pressure in my head. All these symptoms get much worst when I lie down. I lost my job, my partner left me and I've suffered from depression as a result of all this. I've always known something went wrong after COVID. It's good to finally see the reason why. I don't have much hope that I'll get a cure anytime soon but thanks for this. It's a relief of a sort. Edit: I'm not obese. I force myself to walk everyday and sometimes even manage a slow jog. I eat a balanced diet too and try and sleep best I can even though it's painful to do I wake up constantly with the feeling of suffocation.
Remember when morticians started talking about clots they're finding in the corpses they're embalming, and they were labelled "conspiracy theorists" for it? I do.
I'm a mother and carer of a sufferer of ME/CFS of some years. (Struck after a flu-like illness pre-covid.) I would like presenters (even the wonderful Anton) and viewers to stop conflating the notion of "tiredness" with fatigue. It has a strong tendency to minimise the global consequences of severe fatigue leading to misunderstanding, sometimes trivialising, of its effects across the entire body-mind, every single physiological system, every cell, every organ. It is not a worse form of tiredness the rest of us recognise, it is far more pervasive, and devastating. It does not improve with rest nor with exercise. Always good to see progress in research, each piece of the puzzle is valuable. This is how a cure will eventually be found. Thanks Anton!
I’m really excited about long COVID research because it’s so similar to my autoimmune disease. I’ve had it for 24 years and Rheumatologists keep switching what they call it.
I've had chronic fatigue syndrome for 32 years, from back when medical people were sarcastically calling it "yuppie flu". I wasn't a yuppie, I was a 17 yr old who'd been hospitalized with mono (Epstein Barr Virus) because it was so bad they thought my spleen might need to come out. It was swollen to the rupture point. Nurses wrapped me in foam padding, and I had to ring for help if I wanted to roll over. I slept as much as 20 hrs a day for 4 weeks. They said they'd never seen someone hit so hard by EBV. I was so weak that I needed 2 years of physical/vocational rehab to drive a car and stay upright in the daytime. Still, nobody believed me that I felt so exhausted, it was as if the infection had never truly gone. Doctors called it neurotic, dependent needs for affection and attention when I kept coming to them for answers about the pervasive lethargy and relapsing symptoms (the thing I couldn't understand their dismissive attitude about most) like my constantly swelling/shrinking spleen. My family called me a na'er-do-well, my husband called me a drama addicted burden, doctors called me a neurotic liar. But here came long COVID, and there's so many people suffering various degrees of debilitation, from persistent crushing fatigue with vague symptoms that come and go, to full on relapses of the acute illness, that we can't all be liars, so here we are, researching and finding things like little foreign structures in blood. I'm pushing 50 now and it hardly matters to me. I pace myself as a homemaker and do what I can do each day. My kids are grown. The times when I had dreams for a career and a life full of pursuits are gone. I hardly care what happens, except I'm very happy the younger people, like PhysicsGirl, might have a chance at a real life. They don't deserve this. None of us do. The medical establishment can kiss my a$$. If they'd lifted a finger for people like me when we were begging for help, the virology might have been in place to prevent anyone from suffering so much from COVID.
From a medical professional standpoint, the multitude of widely different symptoms absolutely screams that it's a vascular problem, which could readily effect multiple organs and systems throughout the body, and with a wide variety of presentations. So microclots and possibly associated vasculitis are very strong contenders for the main cause of long COVID.
This hits hard...Ive never been the same since 2021,when I had my first infection with delta variant. Brain fog and cognitive problems being the main incapacitation. It was hell. Every test came back normal, I didnt know what was going on and the impact it had on me was awful. I was 18 back then...Thank you so much Anton for bringing light to this topic!!
Your channel doesn't get enough praise, thank you