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Joscha Bach: Why We Still Can't Simulate a Worm's Brain

2026-05-09 Science & Technology
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Dr Brian Keating
Dr Brian Keating
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Description

A cognitive scientist who's spent twenty years building cognitive architectures says the entire connectome project is mapping the wrong layer of the brain — and a 302-neuron worm is the proof. Joscha Bach is co-founder of the California Institute for Machine Consciousness and one of the most original thinkers on mind, computation, and the substrate of cognition. We cover: why mapping every synapse in C. elegans for forty years still hasn't produced a working simulation, what neurons might actually be doing if they aren't the computers, why mind uploading rests on an unexamined assumption, the telegraph-wire analogy that reframes the whole field of neuroscience, and the experimental result that would change his mind. Neurons may be the wires. Not the chips. 📬 Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt 🌠 Have a .edu email and live in the USA 🇺🇸? You automatically win a meteorite: https://BrianKeating.com/edu 🔔 Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 🎯 Support Into the Impossible on Patreon — get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating ⭐ Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 My books: Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U Galileo's Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un 🌐 More: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating ✍️ Blog: https://briankeating.com/blog 🎙️ Audio-only: https://briankeating.com/podcast #intotheimpossible #briankeating #science #physics #astronomy #cosmology #podcast #universe

Top Comments (10)

@DrBrianKeating 2026-05-08

A worm with 302 neurons. Mapped completely since 1986. *Forty years later, no simulation can reproduce its behavior.* If we can't get a worm out of perfect wiring data, what does that say about every plan to upload a human brain? *Watch the clip and tell me where Joscha is wrong.* Full 90m convo coming soon!

14 2 replies
@ryateo1 2026-05-09

Basically we don't know nearly as much as we proclaim to know.

7
@Thomas-gk42 2026-05-09

Sounds remarkable interesting. Waiting for the whole thing with Josha bach.

6 1 replies
@doloresabernathy9809 2026-05-09

This is the most insightful thing I have heard from Joscha Bach. He is right that the “hardware” of animal nervous systems is grossly over-simplified when it’s assumed to fit the digital computer paradigm.

6
@45414 2026-05-09

Not only can we not deterministically model a cell, we can’t deterministically model a single sodium channel.

4 1 replies
@MS-od7je 2026-05-09

It is my understanding that the fruit fly connectome made the fruit fly behave more like a fruit fly than an LLM generated software for fruit fly behavior. The odd thing is that the C Elegans connectome ran the fruit fly behavior the same as the fruit fly connectome. Like chasing zebras in strobe lighting

3
@Beerbatter1962 2026-05-18

This study about how a caterpillar's brain is liquefied during metamorphosis, and later re-built while preserving memories, has me blown away. That is insane. Man, we still have so much to learn about nature.

2
@tinderbox1011 2026-05-09

It's all computers but algorithms don't accumulate.

2
@nathandanner4030 2026-05-11

"Deep in the human unconscious is a pervasive need for a logical universe that makes sense. But the real universe is always one step beyond logic."-Frank Herbert

2
@wolphramjonny7751 2026-05-11

While many larval neurons die off, some of the specific connections formed in the mushroom bodies during the caterpillar stage are preserved and integrated into the more complex adult brain.

1

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