Scientific Proof: 25g Of This INSTANTLY Heal No Sleep Brain Damage

25 g creatine

According to a very recent Physionic video, a solid study showed that people who are sleep-deprived _and_ take a mega dose of creatine (25g perhaps) functioned cognitively better than people who weren't sleep-deprived _but_ didn't take the mega dose of creatine, which I think is truly remarkable. I wish I had known this when I was a shift worker.

The most dangerous effect of sleep deprivation is not lack of energy production in the brain. Is that cerebrospinal fluid had no time to flush all the "dirt" out of the brain.

Anyone watching the video and reading this needs to understand there's no substitute for sleep. In the 90's I've done IT support for hospitals (pretty much all of them, their labs/radio systems and even one payroll) in Auckland NZ on 24/7 basis (there was another person with me on the task) for two years and all I can say don't do it-if the scope of work requires four or more people then the company should not just hire two.

I wish I had known this a year ago. I used to work crazy hours, some weeks 80 with no sleep for 30 hours almost weekly. Eventually my body crashed. I never thought that would happen to me. I have reduced my hours and tried to fix myself with a lot of mistakes along the way. I'm so grateful I found this channel. If I had any hypes left I'd give you the all. I owe you!

anything above 5g and my kidneys are not happy. Can't imagine taking this much.

Take 25g and poop your pants!

I took 25g and couldnt leave toilett without taking a pill stopping it

Interesting.... I've actually been running ~15g/day and had zero side effects, but I think context matters a lot here. I'm not taking it in isolation. I'm already getting roughly 15–20g glycine daily, 500mg nicotinic acid, and at least ~2g taurine, plus solid methylation support (choline, B12, folate, etc.). So my methyl donor / methyl sink balance is probably very different than someone just adding creatine on top of a typical diet. From a mechanistic standpoint, creatine actually reduces endogenous methylation demand (since your body doesn’t have to synthesize as much creatine from glycine + arginine using SAMe, so it also preserves arginine for NO), which can be beneficial if methylation is a bottleneck, but that also means the net effect depends heavily on the rest of your stack and baseline status. So I’d be cautious about blanket claims like “creatine upregulates methylation” or that it universally causes issues... seems way more like it shifts methylation dynamics, and whether that feels good or bad depends on the system it's entering. In my case, with high glycine (methyl buffering), taurine (osmotic + neurological stabilization), and adequate methyl donors and sinks (Nicotinic acid), it’s been completely smooth, even at higher doses. Curious if the people getting anxiety/irritability are running it without that kind of support stack.

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