Why the Body Set Weight changes EVERYTHING about weight loss| Jason Fung

The great thing about fasting is it actually increases the metabolism when you do fasts 96h and under. It also regenerates organs like the thyroid at the end of the fast due to growth hormone generation. Hormons like testosterone slowly wane with age but in both men and women, growth hormone reduces by 2/3 as soon as we are adults and stays that way forever for most people. The many benefits of occasional extended fasting and lowering dietary carbs: Your body recycles up to 1/3 of all immune cells in a 72h fast, rejuvenating your immune system. This helps with autoimmune disease, cancers and cytokine storm. Reduces B cells by over half in a single fast, greatly reducing allergic and other autoimmune responses. Fasting and low carb help with POTS, which is driven by high insulin and blood sugar. Fasting reduces cortisol over time and improves your circadian rhythm. Fibrosis aka scarring is reversed over time, including in the heart, lungs and clots. Clotting and fibrin are inhibited, stopping any 'unusual' clots. Fasting stimulates phagocytosis, the ingestion of proteins, pathogens and plaques by macrophages and other immune bodies. This will remove spikes quicker, whether natural or unnatural in origin! Fasting restores NAD+, reduces NADH and increases nitric oxide release to open blood vessels. Reflexes and short term memory are increased. Fasts from 36-96 h increase metabolic rate due to norepinephrine release!. Blood sugar and insulin are lowered when fasting, reducing inflammation and allowing the immune bodies to move freely through the body. T cells are cruciall in fighting cancer, autoimmune disease and infection. With age, the thymus generally stops making them but fasting releases stem cells, which then can become new T cells. It also releases growth hormone, which regenerates the thymus! When insulin is high, vit D stays locked in the blood cells but fasting quickly lowers it. Vitamin D plasma levels are increased as fasting improves metabolic health, and D in turn increases autophagy. Fasting increases anti-aging Yamanaka factors and increases average telomere length in stem cell pools. Fasting increases interferon, which shuts down the ability of viruses to replicate. Clots and plaques are removed over time due to accelerated phagocytosis. The hunger hormone ghrelin also lowers with extended fasting and rises from dieting. Fasting does not reduce testosterone over time. Iraises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building. And removes fat, which also increases estrogen in men. Fasting activates autophagy (literally self eating). This recycles damaged proteins and foreign matter such as viruses. Fasting can help with MS, Depression, BPD, Autism and seizures. Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The obese will lose loose skin while fasting, but the frail will have increased growth hormone release, which helps to make more lean tissue and reduce frailness. It increases mitochondrial function and repairs mtDNA. Mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention! 24h of fasting reduces leptin levels by half! This reduces leptin resistance, which impairs immune function. Over time fasting normalizes stomach acid levels and during the fast acid levels go down to allow for the healing of ulcers. Fasting reduces pain and anxiety by stimulating the endocannabinoid system, just like the effect of CBD oil Your brain prefers to burn ketones at a rate of around 2.5 to 1 when equally available to glucose. Except for brief periods of very intense exercise, your body mainly burns free fatty acids. When not in ketosis, the brain can only burn glucose, which produces a great deal of damaging ROS the brain has to deal with. Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility for some women. Fasting releases BDNF and NGF in the blood, creating new nerve and brain cell growth. This helps a great deal with diseases like MS, peripheral neuropathy and Alzheimers. Fasting stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer. Glycine and trimethylglycine (TMG) can also be useful supplements while fasting that won't break ketosis and have many benefits. A fasting mimicking diet for 3-5 days in a row provides many of the same benefits as water fasting. FMD has about 200-800 calories, under 18 g of protein and zero net carbs. What breaks a fast? Anything with protein or carbohydrates in it will break a fast but most teas and herbs are OK. Supplements and meds usually break ketosis directly or contain a filler that wil, or irritate the stomachl. Many meds are dangerous to take while fasting. Exogenous ketones can aid with fasting, allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. They also help with dementia and many other issues even if you take them while not fasting! Children, expecting or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors that excrete insulin or certain rare forms of hypoglycemia generally cannot fast at all or only with doctor supervision. T1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis and done under doctor supervision. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast with a low carb meal. Resources: https://www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits https://pubmed.ncbi.nlm.nih.gov/31890243/ http://www.sciencedirect.com/science/article/pii/S0005272806000223 https://www.ncbi.nlm.nih.gov/pubmed/23876457 https://www.sciencedirect.com/science/article/pii/S1931312809002832 https://www.ncbi.nlm.nih.gov/pubmed/10859646 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/ https://www.nejm.org/doi/full/10.1056/NEJMc2001176 https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17852 https://www.clinicaltrials.gov/ct2/show/NCT04375657 https://pubmed.ncbi.nlm.nih.gov/20102774/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ https://www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf https://pubmed.ncbi.nlm.nih.gov/27569118/ https://pubmed.ncbi.nlm.nih.gov/23408502/ https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 https://repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ https://pubmed.ncbi.nlm.nih.gov/23707514/ https://pubmed.ncbi.nlm.nih.gov/20921964/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue https://pubmed.ncbi.nlm.nih.gov/28235195/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ https://medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html https://www.cell.com/cell/fulltext/S0092-8674(19)30849-9 https://clinical.diabetesjournals.org/content/36/3/217 https://www.ncbi.nlm.nih.gov/pubmed/25686106 https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x https://academic.oup.com/ajcn/article/81/1/69/4607679 https://www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext https://www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ https://pubmed.ncbi.nlm.nih.gov/7714088/ https://www.nejm.org/doi/full/10.1056/NEJMoa012908 https://pubmed.ncbi.nlm.nih.gov/15522942/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/ https://pubmed.ncbi.nlm.nih.gov/31877297/ https://www.ncbi.nlm.nih.gov/gene/25712 https://pubmed.ncbi.nlm.nih.gov/33530881/ https://www.biorxiv.org/node/93305.full https://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart https://pubmed.ncbi.nlm.nih.gov/25909219/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/ https://europepmc.org/article/MED/22402737?javascript_support=no https://pubmed.ncbi.nlm.nih.gov/2518860/ https://www.ncbi.nlm.nih.gov/pubmed/24905167 https://pubmed.ncbi.nlm.nih.gov/29727683/ https://n.neurology.org/content/88/16_Supplement/P3.090 https://pubmed.ncbi.nlm.nih.gov/6859089/ https://www.ncbi.nlm.nih.gov/pubmed/10232622 https://pubmed.ncbi.nlm.nih.gov/21410865/ This list compiled over years of research by the user known as Pottenger's Human on youtube. Feel free to copy and paste this anywhere you like, no accreditation needed!

If anyone is interested or needs more motivation: l was a fat, sick, very old-looking woman in Feb 2023 with a BMI of 34.5 (dangerously obese for my height), now I am getting IDd at bars again :D I shed 76lbs in 6 months last year using fasting (between 24-76 hours most days of every week for the whole 6 months) and intense endurance exercise. I went from an XL to an XS :) All the obesity-related health-issues I was enduring had a total reversal. My skin shrank to the extent I am _constantly_ accused of surgery from randoms who see my transformation on the internet (it’s all documented). I also built muscle, fitness, and endurance from the bodyweight HIIT exercises and walking I was doing! At almost 36 years old I am now getting ID’d again 😊 (Also I’m a mother of two teenagers! My belly looks like I haven’t had babies or ever been obese) Anyway part of what I’m here to say is that most days I drank strong dark coffee (the plunger kind), with cream in during my fasts :o usually just one big cup with a splash of cream. So this confirms what Dr Fung has said in other videos that cream may not have a negative affect on autophagy ^_^ (though it may depend on the individual! I’m talking real cream from a cow, not artificial creamer) Also it’s been a year since I shed the weight and have effortlessly maintained - my “set point” seems to be somewhere between 116-120lbs now?? I’m 5’2”, I eat OMAD as a lifestyle, and also do carnivore a lot of the time. I do running for exercise. I’d prefer walking but I’m often busy so I get the exercise done faster if I run. Also I did all this in poverty!! People have told me I’m lying because I’d have to be rich for all the surgeries I’ve had 😅 But my front tooth is broken and badly coffee stained because I can’t even afford a dentist lol (not begging here, I don’t accept money or donations, I’m just trying to emphasise what’s possible even with no resources!! Hopefully this can help give you hope and motivation if you see it :D

People can say whatever they want. I water fasted for 92 days and cured my stage four cancer. Not only that but I lost a ton of weight with no loose skin. Got off ALL my medication and look younger than I am by 20 years. It works. I was morbidly obese. I’m still fat but I’m not dying and continue to lose through OMAD and keto diet

Hi Dr. Fung, I followed your advice about intermittent fasting. I lost 15 pounds in 3 months. My A1C from 6.3 to 5.8. I appreciate your time and effort to make these videos on YouTube ! Thank you for your help 🎉

Any treatment for obesity that doesn't treat the body fat thermostat is doomed to fail over the long term.

Jason is the best thing that ever happened to human health.

Thank you Dr. Fung. Your analogies are so helpful.

Check out my video "Can Fasting reverse Kidney Disease?" - https://youtu.be/SI_c16-_dqw

You are my favorite person. In the recent video, you said you made people fat and didn't know better, and now you know and are correcting your error and HELPING people. 💚 I love you! Thank you. The only doctor I trust.

I see why everyone loves you. Is it your boyish good looks? Your sweet way of explaining things? Yes-- and your knowledge. I can say these things because I'm old enough to by your grandma. Thanks for all you do for us.