The Biological Upgrade: Turning Your Immune System Against Aging

How natural killer cells clear senescent cells — and why this system breaks down with age. Dr. Amit Sharma, Lifespan Research Institute. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Qualia* (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd Senolytic https://bit.ly/4jlaibe *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Dr. Amit Sharma is Group Leader in Senescence Immunology at the Lifespan Research Institute (formerly SENS Research Foundation), where his lab studies how the immune system interacts with senescent cells and how that relationship breaks down with age. In this first segment of our conversation, Dr. Sharma explains what natural killer (NK) cells are, how they identify and eliminate senescent cells, and why their ability to do so declines as we get older. He also reveals how senescent cells actively fight back by developing tricks to evade immune detection and suppress NK cell function. This is a fascinating look at the biology underlying one of the most promising frontiers in longevity research. 🔬 Topics covered: - What senescent cells are and why they accumulate with age - Which parts of the immune system clear senescent cells - The life cycle and function of natural killer cells - How and why NK cell activity declines with age - How senescent cells actively evade immune surveillance - Why chronic inflammation (inflammaging) paradoxically suppresses NK cell function - How NK cells identify senescent cells using activating and inhibiting receptors ▶️ This is Part 1 of my full interview with Dr. Sharma. Links to other segments below as they are released. 📚 Chapters 0:00 Introduction & Dr. Sharma's lab 1:49 Which immune cells clear senescent cells? 5:58 How NK cell activity changes with age 8:44 Why inflammation suppresses NK cells 11:26 How NK cells identify senescent cells 🌐Links in this video Lifespan Research Institute: https://lifespanresearchinstitute.io Dr Sharma's lab page https://lifespan.io/our-research/sharma-lab/ #Longevity #Senescence #NaturalKillerCells