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Blood Brain Barrier Health - Endothelium Focus

2025-06-25 Education
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Drbeen Medical Lectures
Drbeen Medical Lectures
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Description

A ‘leaky’ blood-brain barrier (BBB) lets cytokines, pathogens—even heavy metals—invade your brain, fueling brain-fog, migraines, dementia risk, and long-COVID neuro-symptoms. In this CME-eligible masterclass, Dr Mobeen Syed shows how to detect, prevent, and manage BBB breaches. 🩺 **You’ll learn** • Why most antibiotics can’t cross an intact BBB—and how inflammation changes that • How gadolinium MRI pinpoints endothelial leaks • What efflux pumps like P-gp mean for chemo & anti-viral resistance • How aging, diabetes, and Alzheimer’s reshape barrier function • Why claudin-5, occludin, and ZO-1 should be on your diagnostic radar 🎓 **Claim CME & find more lectures** https://www.drbeen.com 🌟 **Support my work** ☕ Buy me a coffee → https://www.buymeacoffee.com/DrMobeenSyed 🎥 Patreon → https://www.patreon.com/mobeensyed?fan_landing=true 💵 PayPal → https://paypal.me/mobeensyed?locale.x=en_US 📬 Substack → https://mobeensyedmd.substack.com/ 🛑 **Medical Disclaimer** This video provides educational information only and is not a substitute for professional medical advice. Consult your healthcare provider for personalized guidance.

Top Comments (10)

@techadsr 2025-06-25

BBB = Brain's firewall

9 1 replies
@leeroyjenkins5193 2025-06-27

I asked a neurologist today if in the elderly (80+) if the blood brain barrier will allow more through. In other words weaken or be more permeable with age. My concern was her beta blocker Metoprolol, even with it being low dose that more could be penetrating and causing more adverse side effects. His response was no, it doesn’t weaken overtime & her behaviors were most likely a form of early dementia or Alzheimer’s. Of course the next step is to put on more meds like a dementia drug and a depression drug for mood. Our health care or some would say “sick care” is to pile on drugs one after the other without ever considering the one drug your on could be causing some of the issues that lead to more drugs to treat the new side affects. Anyway, it feels hopeless out here. Hard to get a Dr that thinks outside the box and doesn’t just go for the next pharmaceutical treatment. Thanks again for all of your videos. Wish there were Dr’s out there that know & think like you do. 🙏

6 5 replies
@hermannmehl931 2025-06-25

Vielen Dank, sie können komplizierte Dinge sehr gut vereinfachen und verständlich machen. So macht Lernen Spaß.

4 1 replies
@kennethmurage3625 2025-07-04

I wonder how difficult this topic would be without the diagrams !! Thank you Dr.. for the efforts . 😎👉👉👉 Kenya🇰🇪

3 2 replies
@spaight711 2025-06-25

That we can measurably increase BBB permeability with ultrasound and that we routinely expose humans to ultrasound, albeit significantly lower intensity and duration, antenatally is something that absolutely needs to be explored. We have no idea what long term impacts of developmental neurological exposure to untold thousands of substances might be.

3 2 replies
@OliverKahnOffiziell 2025-07-04

To know that in Long Covid this layer is systemically inflamed is utterly distressing. Death sentence.

3 1 replies
@scottmiller2591 2025-06-25

Excellent review. One thing not often appreciated is that blood is _toxic_ to neurons, and kills neurons almost instantly on contact. This is why brain surgery was unsuccessful until electrosurgery was invented, as the blood spilling over the cortex from a conventional scalpel would simply kill every neuron it touched. Electrosurgery with the proper waveforms avoids this by sealing capillaries and vessels at the same time it transects tissue, preventing this toxic spillage.

3 1 replies
@monawenger932 2025-06-25

Like the illustrations. We need young persons to go into the medical field. I know your illustrations are elementary, but that does not matter. The body is the body and will not change unless disease sets into the system. It is so important to k is about the blood brain barrier in this time.

2 2 replies
@eltineloveall8559 2025-06-28

Thank You for another discussion. I learn each time. I am so thankful you have continued to provide such quality medical/ body issues. Be Blessed.

2 1 replies
@bettyjeanpetrinovich7373 2025-07-10

Thank you for the efforts you invested in your presentation. 🎉 Long ago I was completing a paper on mildTBI for a class assignment. One research team reported that tomatoes caused lysis of astrocytes. That was 20 years ago, and I can't find the original research paper. Are you aware of any research into this?

1 1 replies

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