GLP-1s, Weight-Independent Longevity, and the Risk of Muscle Wasting | Dr Mikhail Kolonin

Dr. Mikhail Kolonin from The University of Texas Health Science Center at Houston explains the 'weight-independent' metabolic benefits of GLP-1 agonists and the critical risks of muscle wasting. Discover how these therapies trigger adipose tissue browning and why resistance training is essential to maintaining healthspan during treatment. This is the full interview from the previously released sections. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ In this full-length interview, Dr. Mikhail Kolonin of the UTHealth Institute of Molecular Medicine shares his groundbreaking research on the metabolic effects of GLP-1 agonists. We dive deep into how these drugs trigger 'weight-independent' metabolic reprogramming through IL-6 signaling and adipose tissue browning, while also discussing the critical risks of skeletal muscle loss. Dr. Kolonin explains why resistance training and protein intake are essential for anyone using these therapies and what the future holds for adipose-targeted regenerative medicine. 📚 Chapters 0:00 How GLP-1 Agonists Work: Appetite vs. Metabolic Reprogramming 6:15 Direct Effects of GLP-1 on Adipose Tissue & IL-6 Signaling 12:30 Weight-Independent Longevity: The Key to Metabolic Health 18:45 Understanding "Browning" of White Fat for Energy Expenditure 24:10 The Dual Nature of IL-6: Friend or Foe in Longevity? 30:52 Preventing Muscle Wasting: The Dark Side of GLP-1 Agonists 37:20 Why Resistance Training and Protein are Non-Negotiable 44:05 Can GLP-1s Directly Affect Cancer Progression? 50:18 Metabolic Toxicity: How Visceral Fat Accelerates Aging 56:40 The Role of Telomerase in Macrophages and Inflammation 1:04:30 Future Directions: Clinical Trials in Older Populations Scientific References & Clinical Trials: GLP1 Receptor Agonists-Effects beyond Obesity and Diabetes PMCID: PMC10778154 DOI: 10.3390/cells13010065 https://pubmed.ncbi.nlm.nih.gov/38201269/ 🌐Links in this video Dr Kolonin's page https://gsbs.uth.edu/directory/profile?id=b816c8de-c9b0-40f0-873c-42fa69db82e9 #glp1 #Longevity #mitochondrialhealth RESEARCH NOTICE: This content discusses emerging research in longevity and biotechnology. The studies and protocols mentioned are for informational purposes only and do not constitute an endorsement or medical recommendation. Scientific consensus can change, and the application of any research discussed is at the viewer's own risk. Please consult a healthcare professional before making any changes to your diet, supplement, or exercise routine.