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Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan Williams

2026-06-04 Science & Technology
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Andrew Huberman
Andrew Huberman
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Description

_In loving memory of Nolan Williams (1982-2025):_ ⁠⁠https://stan.md/3Qle2zp⁠⁠ In this Huberman Lab Essentials episode, my guest is Dr. Nolan Williams, MD, a triple board-certified psychiatrist and neurologist. We discuss cutting-edge treatments for depression and post-traumatic stress disorder (PTSD), including transcranial magnetic stimulation, neuromodulation, and psychedelic-assisted therapies. We also discuss the neurobiology and therapeutic potential of specific psychedelic compounds, including psilocybin, MDMA, ibogaine, and ayahuasca. Show notes: https://go.hubermanlab.com/KWwu7p6 Huberman Lab Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Timestamps 00:00:00 Nolan Williams 00:00:26 Depression 00:02:51 Heart & Mind Connection, Transcranial Magnetic Stimulation (TMS) 00:05:21 TMS for Depression 00:07:52 SSRIs & Chemical imbalance, TMS, Psychedelics 00:13:51 Psilocybin, MDMA, Trauma 00:16:48 MDMA Clinical Trials & PTSD; Psilocybin & Depression 00:18:46 Psilocybin, Brain Connectivity & Depression 00:21:07 Ibogaine, Empathy; Psychedelic Breakthrough & Risk 00:27:44 Ayahuasca, Behavior Change, Prisoners 00:31:54 Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) 00:35:56 Acknowledgements #hubermanlab #science Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Top Comments (10)

@Neuroshiftdaily 2026-06-04

The future of healing may not be about escaping pain, but rewiring the brain to stop living inside it. Science is starting to show how much change the mind is capable of.

21 2 replies
@renatachapa8331 2026-06-04

Since te very first moment I saw him in his TED TALK, I felt an opression in my chest. He is in peace. He gave us love though his knowledge of our horrible struggles. ❤❤

10
@danieljoel7326 2026-06-04

Heartfelt legacy bringing the Baton forward of this necessary critical knowledge and research area that Dr Robin Carhart Harris and Dr Huberman and r.i.p Dr Nolan williams together now with his widowed wonderful wife and Dr Liston and others , Dr Rosalind Watts and Imperial college team and so many more have with Dr Nora Volkow or Tim Ferris and many more , Marcus Amber. Bless everybody and never stop bringing public health to its most efficacious applied wayof our medical research and clinical application. We will get there Daniel Joel of NYC , thank you Dr Nolan (Ryan) Williams for your gifts. the mystery of our human condition is making some of us precarious along the way, as you were, but the legacy is moving forward , always

5
@sofiasiraj3281 2026-06-04

OWEEE so early 😃

2
@olgazavilohhina6854 2026-06-04

¡Hola Profe!May Dr Williams's work and mission live on.Thank You for all Your hard work and care for all of us.

2
@danielmathews4859 2026-06-04

Thank you Dr!

1
@wufbwl236 2026-06-04

드디어 한국어 번역 ! 감사합니다

1
@sonjajvr1912 2026-06-05

@Andrew, only saw now dr williams died. May he be resting in peace now. You have been on my heart Andrew brother, praying for you right now.

1
@TheSilentPattern97 2026-06-05

The discussion on Ibogaine and its impact on 'moral injury' in special operations veterans is profoundly moving. Traditional therapies often struggle to address the deep-seated guilt and trauma associated with severe vocational stress. Hearing that a single, highly structured clinical session can induce a plastic state allowing individuals to achieve detached empathy and genuine self-forgiveness highlights why we must approach these compounds as serious, medically supervised breakthroughs rather than recreational subcultures.

0
@deborahperkins6764 2026-06-05

This has me in tears. We also lost this battle, and it was well fought, 5 years ago with my beautiful daughter. I want to learn more about this and admire you for your work and he for his ❤❤❤

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