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Essentials: Understanding & Healing the Mind | Dr. Karl Deisseroth

2025-05-15 Science & Technology
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Andrew Huberman
Andrew Huberman
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Description

In this episode of Huberman Lab Essentials, my guest is ⁠Dr. Karl Deisseroth, M.D., Ph.D.⁠, a clinical psychiatrist and professor of bioengineering and of psychiatry and behavioral sciences at Stanford University. We discuss his experiences as a clinician treating complex psychiatric conditions and his lab’s pioneering work in developing transformative therapies for mental illness. He explains the complexities of mental illness and how emerging technologies—such as optogenetics and brain-machine interfaces—could revolutionize care. We also explore promising new therapies, including psychedelics and MDMA, for conditions like depression and PTSD. Episode show notes: https://go.hubermanlab.com/0M1gSQ0 Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/w9MXqXBZy9U Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Dr. Karl Deisseroth* Stanford academic profile: https://profiles.stanford.edu/karl-deisseroth Website: http://deisseroth.com Lab website: https://dlab.stanford.edu Projections: A Story of Human Emotions (book): https://amzlink.to/az0jxcLUA11Dj X: https://x.com/KarlDeisseroth *Timestamps* 00:00:00 Karl Deisseroth; Neurology vs Psychiatry 00:01:36 Speech; Blood Test?; Seeking Help 00:04:20 Feelings, Jargon; Psychiatric Treatment 00:09:40 Future Treatment; Vagus Nerve Stimulation, Depression, Optogenetics 00:18:24 Brain-Machine Interfaces 00:19:37 ADHD Symptoms, Lifestyle, Technology 00:26:10 Psychedelics, Depression Treatment, Risks 00:32:19 MDMA (Ecstasy), Trauma & Post-Traumatic Stress Disorder (PTSD) Treatment 00:35:21 Projections: A Story of Human Emotions Book, Optimism Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Top Comments (10)

@mihailovasic4088 2025-05-15

I used to think healing the mind meant fixing what was "broken" in me. But this conversation helped me see something deeper: our mind doesn’t need fixing it needs understanding. For years, I carried silent pain. Smiled in public, collapsed in private. Therapy helped, but I still felt like no one truly saw the inner storms. Until I stumbled upon this video. Dr. Deisseroth doesn’t just talk science he brings compassion into it. It reminded me that our mind is not the enemy. It's a messenger. And every symptom anxiety, burnout, numbness is the psyche’s way of whispering: listen to me. I paired this insight with the tools I found in Instant Deep Relief from Manifest Zen especially the body-based exercises that helped me feel safe in my own skin again. If you’re lost, overwhelmed, or quietly battling something no one sees… start here. Understanding is the first step. Healing follows.

151 7 replies
@hubermanlab 2025-05-15

Thank you for watching! If you enjoyed this topic and episode, please click the “Like” button and subscribe to our channel on YouTube. Thank you for your interest in science! — Andrew

51 8 replies
@patrickwayne9074 2025-05-15

How weird that I discovered Huberman by watching ASAP science. This is way more my type of zero-cost info. Awesome channel.

21
@crystalng7064 2025-05-15

Dr Karl Deisseroth is an absolute gem! Gotta reread his beautifully written book again

15
@jepollabauer 2025-05-16

The discussion between Dr. Karl Deisseroth and Dr. Huberman has to be one of the best podcasts I have listened to regarding brain science and the practical functioning of the brain and its many abnormalities and ailments. I can’t wait for Dr. Huberman to bring Dr. Deisseroth back for more discussions on brain science

13 1 replies
@FordyoutubeWatson 2025-05-15

Really would love to see Dr deisseroth again on your podcast. He was and still is a huge inspiration in my life, what an amazing human

9
@gmo2932 2025-05-15

Excellent interview. Mind related science is hard to quantify but this guy is a true professional and kept it neutral.

4
@sujathakorlam8429 2025-05-16

It's a wonderful conversation, regarding high functional ADHD, from my practical experience..outward they look bright but inside it will be a storm , I think it differs from person to person ..for a border line high functioning ADHD they just need ," positive words" , " validating words " ..any negative words will break them emotionally 😭😭

3
@pewsessions 2025-05-15

Thank God, I Hope everyone can heal and learn to be better. ❤

3
@zunamiii 2025-05-16

This looks like an old recording … I love this guy Karl :)

2

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