Top 4 Supplements That Make You Lose Vitamin D Like Crazy

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1:04 vitamin D2 3:36 high vitamin A 5:46 Calcium competes with Magnesium 7:18 CYP3A4 Activators break down Vitamin D (St John’s Wort, etc)

6:04 The story of how D3 is converted by the liver and then by the kidneys is something we learned back in the 1900's. Those two conversions are also done in all somatic cells with a nucleus. Please check out "The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes." Dr. Hollis goes over the paper in a YouTube video "Dr. Bruce Hollis - Vitamin D Dosing Interval." If you watch that you will know more than 99% of doctors.

Learning something new never stops! Thanks!😊

# ⚠ Supplements That Can Lower Your Vitamin D Many people already have low vitamin D (causing low mood, fatigue, weak immunity, and poor muscle strength). Adding certain supplements can make it worse. --- ## 1. Vitamin D2 🌿 **Yes, a vitamin D supplement can lower your vitamin D.** - D2 raises your *weak* D2 levels but **lowers** your stronger, more bioactive D3 levels - Studies show D3 can drop from ~40 → low 30s when taking D2 - Why? D2 speeds up D3 breakdown in the liver and competes for binding proteins - **Check your supplements** – cheap multivitamins often use D2. Vegans can use lichen-based D3 instead. --- ## 2. High-Dose Vitamin A (Retinol) 🥕 Vitamin A and D share the same receptors and pathways – they compete. - High-dose retinol blocks vitamin D from binding to cell receptors - It also increases vitamin D breakdown in the liver - **Balance matters** – natural sources like cod liver oil have a ~10:1 (A:D) ratio, a good starting point --- ## 3. Calcium 🦴 Calcium doesn't directly lower vitamin D, but it competes with **magnesium** – and magnesium is required to *activate* vitamin D. - Both liver and kidney activation steps need magnesium-dependent enzymes - Low magnesium + high calcium = sluggish vitamin D activation - Most people are already calcium-dominant. If you take calcium + D, also take **magnesium and K2** --- ## 4. St. John's Wort 🌼 This herbal antidepressant strongly activates **CYP3A4** – a liver enzyme that breaks down vitamin D. - Your body chews through vitamin D faster than you can replace it - Effect can last for a week even after stopping the herb - Same pathway explains why St. John's Wort interacts with antidepressants, birth control, blood thinners, and painkillers --- ## 💡 Bottom Line None of these supplements are "bad" – they just require awareness. Check your forms (D3 over D2), balance fat-soluble vitamins (A & D), support magnesium when taking calcium, and be cautious with St. John's Wort if your D levels are already low.

So, mushrooms (sundried)are excellent source of vit D, but D2 form - ouch

I take medications metabolized by CYP3A4, now I know why my vitamin D tested so low

Very interesting the effect of st John's wort! Thanks for explaining this.

I take a mushroom mix pill twice a day, walk outside during lunch for sunlight, and check out the Fadiman videos about microdosing magic mushrooms. Like everything, too much is definitely possible. A few weeks seemed to improve my vision and hearing, and maybe also improved my ability to smell.

Get outside. We did not evolve to live indoors under artificial lights. We were meant to work half naked in the sun.