The REAL Cause Of Dementia

Dementia is a metabolic disease, not a genetic one. Here's what's really destroying your brain, and how to prevent and possibly even reverse it. Dr. Anthony Chaffee MD. 📚 Join the waiting list for my upcoming book at my website www.DrAnthonyChaffee.com - Your Hub For All Things Health and Nutrition Dr. Chaffee's Protocol for Optimizing Multiple Sclerosis Recovery https://dranthonychaffee.com/dr-chaffees-protocol-for-optimizing-multiple-sclerosis-recovery/ References: Domestic pig vs wild boar brain size — 18% reduction (2024)** "How domestication, feralization and experience-dependent plasticity affect brain size variation in Sus scrofa" https://pmc.ncbi.nlm.nih.gov/articles/PMC11407859/ Statin rechallenge / MMSE in Alzheimer's "The Effect of HMG-CoA Reductase Inhibitors on Cognition in Patients With Alzheimer's Dementia: A Prospective Withdrawal and Rechallenge Pilot Study" https://pubmed.ncbi.nlm.nih.gov/22921881/ B12 and brain volume loss in elderly (Oxford 2008) "Vitamin B12 status and rate of brain volume loss in community-dwelling elderly" https://www.neurology.org/doi/abs/10.1212/01.wnl.0000325581.26991.f2 ALSPAC maternal B12 and children's math/language scores "Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood" https://pubmed.ncbi.nlm.nih.gov/33551260/ Chimpanzees vs humans brain shrinkage with aging "Aging of the cerebral cortex differs between humans and chimpanzees" https://www.pnas.org/doi/10.1073/pnas.1016709108 Annelise Barron — P. gingivalis in GBM (2025 preprint) "Identification of gingipains in glioblastoma tumors and evidence that Porphyromonas gingivalis infection reprograms glioma cells toward an immunosuppressive, invasive phenotype" https://www.biorxiv.org/content/10.1101/2025.11.13.686868v2 Annelise Barron — P. gingivalis and innate immunity / Alzheimer's (2025) Barron AE et al. "The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease" https://web.stanford.edu/group/barronlab/PubPdfs/2025/The%20dysregulation%20of%20innate%20immunity%20by%20Porphyromonas%20gingivalis P. gingivalis in Alzheimer's brains — original landmark study (2019) "Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors" https://www.science.org/doi/10.1126/sciadv.aau3333 History of the ketogenic diet Wheless JW "History of the Ketogenic Diet" https://pubmed.ncbi.nlm.nih.gov/19049574/ Johns Hopkins — ketogenic diet as standard of care for epilepsy (2025) Kossoff EH "Ketogenic diet therapy for the treatment of pediatric epilepsy" https://pubmed.ncbi.nlm.nih.gov/39665749/ Ketogenic Diet Therapies for Epilepsy and Other Conditions, 7th Edition (book) Kossoff EH et al. — Publisher link: https://www.springerpub.com/ketogenic-diet-therapies-for-epilepsy-and-other-conditions-seventh-edition-9780826149589.html Alzheimer's disease is Type 3 Diabetes — original paper de la Monte SM, Wands JR "Alzheimer's Disease Is Type 3 Diabetes — Evidence Reviewed" https://pmc.ncbi.nlm.nih.gov/articles/PMC2769828/ Ketogenic diet for Alzheimer's — meta-analysis of 691 patients (2024) "Effects of ketogenic diet on cognitive function of patients with Alzheimer's disease: a systematic review and meta-analysis" https://pubmed.ncbi.nlm.nih.gov/38943982/ Ketogenic drink for MCI — largest single Alzheimer's-spectrum RCT (2021) "Ketogenic drink improves cognition in mild cognitive impairment" https://pubmed.ncbi.nlm.nih.gov/33103819/ Phillips RCT — ketogenic diet in Alzheimer's (2021) "Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease" https://pmc.ncbi.nlm.nih.gov/articles/PMC7901512/ Phillips RCT — ketogenic diet in Parkinson's disease (2018) "Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial" https://pubmed.ncbi.nlm.nih.gov/30098269/ Ketogenic diet in Parkinson's — systematic review (2022) "Ketogenic therapy for Parkinson's disease: A systematic review and synthesis without meta-analysis" https://pubmed.ncbi.nlm.nih.gov/35714419/ Phillips case report — ketogenic diet in Huntington's disease (2022) "Time-Restricted Ketogenic Diet in Huntington's Disease: A Case Study" https://pubmed.ncbi.nlm.nih.gov/35967897/ APOE4, meat consumption, and dementia risk (2026) "Meat Consumption and Cognitive Health by APOE Genotype" https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846712 This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk.