The Cancer That Always Comes Back - Until Now | Pancreatic Cancer Cured in Mice

For decades, the KRAS mutation was considered 'undruggable.' Now, a groundbreaking Spanish study has achieved complete tumor regression. Here is how they broke the barrier. Let's review this groundbreaking Spanish study that has successfully regressed the pancreatic cancer; while also preventing cancer's resistance to the drugs. 💙 Want to support this work? ☕ Buy me a coffee: https://www.buymeacoffee.com/DrMobeenSyed 🎥 Become a patron: https://www.patreon.com/mobeensyed?fan_landing=true 💵 PayPal: https://paypal.me/mobeensyed?locale.x=en_US 📬 My Substack: https://mobeensyedmd.substack.com/ 🛑 Medical Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health-related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. References: Worthwhile course to study to understand more about these mechanisms: Inflammation | DrBeen https://members.drbeen.com/courses/inflammation/HkvpMzD8A Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer | Nature Reviews Gastroenterology & Hepatology https://www.nature.com/articles/s41575-019-0245-4 THE STUDY: A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance | PNAS https://www.pnas.org/doi/10.1073/pnas.2523039122 Scientists achieve pancreatic tumour regression in breakthrough study | Euronews https://www.euronews.com/health/2026/01/28/scientists-achieve-pancreatic-tumour-regression-in-breakthrough-study Born at UC Berkeley: a breakthrough in the treatment of sickle cell disease | Letters & Science https://ls.berkeley.edu/news/born-uc-berkeley-breakthrough-treatment-sickle-cell-disease Born at UC Berkeley: a breakthrough in the treatment of sickle cell disease - Berkeley News https://news.berkeley.edu/2026/01/22/born-at-uc-berkeley-a-breakthrough-in-the-treatment-of-sickle-cell-disease/ Patient Cured of Sickle Cell Anemia With Innovative Gene Therapy | Pharmacy Times https://www.pharmacytimes.com/view/patient-cured-of-sickle-cell-anemia-with-innovative-gene-therapy Mariano Barbacid - Wikipedia https://en.wikipedia.org/wiki/Mariano_Barbacid Shokat Lab https://shokatlab.ucsf.edu/ For related topics and reference diagram: KRAS Inhibitor Tumor Resistance Mechanisms Identified | Inside Precision Medicine https://www.insideprecisionmedicine.com/news-and-features/kras-inhibitor-tumor-resistance-mechanisms-identified/ ERK Feedback Mechanism that keeps the tumor going when KRAS is activated. See figure 1 Relaxation oscillations and hierarchy of feedbacks in MAPK signaling | Scientific Reports https://www.nature.com/articles/srep38244 Diagram for KRAS pathway See Figure 3 KRAS Mutations in Cancer: Understanding Signaling Pathways to Immune Regulation and the Potential of Immunotherapy https://www.mdpi.com/2072-6694/17/5/785 Diagram Functional roles of SRC signaling in pancreatic cancer: Recent insights provide novel therapeutic opportunities | Oncogene https://www.nature.com/articles/s41388-023-02701-x Diagram KRAS Inhibitors– yes but what next? Direct targeting of KRAS– vaccines, adoptive T cell therapy and beyond - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0305737221001572 STAT3 activation and enrichment in ALDH+ cells in EGFR-mutant NSCLC.... | Download Scientific Diagram https://www.researchgate.net/figure/STAT3-activation-and-enrichment-in-ALDH-cells-in-EGFR-mutant-NSCLC-Activation-of-EGFR_fig6_317016447 What is FYN Protein - Creative BioMart https://www.creativebiomart.net/resource/articles-what-is-fyn-protein-654.htm SD-36 | PROTAC STAT3 Degrader | MedChemExpress https://www.medchemexpress.com/sd-36.html#:~:text=Due%20to%20the%20winter%20storm,select%20Quantity%20before%20adding%20items