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Essentials: Understanding & Treating Addiction | Dr. Anna Lembke

2025-06-26 Science & Technology
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Andrew Huberman
Andrew Huberman
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Description

In this Huberman Lab Essentials episode, my guest is Dr. Anna Lembke, MD, Chief of the Stanford Addiction Medicine Dual Diagnosis Clinic at Stanford University School of Medicine. We discuss how dopamine drives reward, motivation and addictive behaviors. Dr. Lembke explains the concept of the pleasure-pain balance of dopamine and how this cycle plays a key role in the development and persistence of addiction. We also discuss some of the challenges of addiction recovery, including withdrawal, relapses and the potential benefits of psychedelic-assisted therapy. Episode show notes: https://go.hubermanlab.com/xbtub2m Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/p3JLaF_4Tz8 Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Dr. Anna Lembke* Website: https://www.annalembke.com *Timestamps* 00:00:00 Anna Lembke 00:00:15 Dopamine, Reward & Movement 00:01:54 Baseline Dopamine; Genetics, Temperament & Addiction 00:05:24 Addiction, Modern Life & Boredom 00:07:18 Pleasure-Pain Balance, Dopamine, Addiction 00:12:39 Resetting Dopamine, Substance or Behavior Recovery, Tool: 30-Day Abstinence 00:14:26 Relapse, Addiction, Reflexive Behavior, Empathy 00:18:39 Triggers, Relapse, Dopamine 00:21:37 Shame, Truth Telling & Recovery 00:23:58 Addiction, Psychedelic-Assisted Therapy, Psilocybin, MDMA 00:29:01 Social Media & Addiction, Tool: Intentionality Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Top Comments (10)

@Danimal1965 2025-07-02

I am 2.5 years clean from 25+ years of alcohol, weed, and cigarette addiction in large part because of watching Dr. Huberman's discussion with Dr. Lembke recorded about three years ago. Ridding myself of addiction to all three at the same time was no picnic, but I did it. Their discussion just made sense and was something I thought a lot about as I fought off bouts of doubt and difficulty. PS, quitting cigarettes was for me by far the hardest addiction to quit. I'll never go back to any of them again. I'm just done. For anyone reading this ready to quit: Give yourself about six months to shed all the crap. It does get better. 3 days hell; 3 weeks heck; 3 months okay; 6 months - clean. Thank you, doctors!

612 28 replies
@DavidKatz-k3r 2025-06-30

I sent an email to Dr Lembke after first hearing the original podcast years ago. She wrote me back in less than 5 minutes. Despite how busy she must be, she had the heart to do that at which has helped carry me through sobriety.

264 7 replies
@hubermanlab 2025-06-26

Thank you for watching! If you enjoyed this topic and episode, please click the “Like” button and subscribe to our channel on YouTube. Thank you for your interest in science! — Andrew

154 17 replies
@dailyorangepill3338 2025-06-26

Alcohol is not just a drink—it’s a spiritual weapon dressed as celebration. You've been taught to see it as harmless, fun, even sophisticated.

98 6 replies
@midnightprophet7935 2025-09-06

I was a heroin addict for 20+ years. Hopped off 5 mg of methadone after weening down. 4 weeks later, I took my 1st serving of ayahuasca. Changed my ENTIRE life 180°. Integration and disciplined practices being the MOST important parts. I've got a 40k word book I'm trying to get published this year. Huberman and others like him have been instrumental in my continued growth to good health, abundance, and an extremely fulfilling life where I now....help others.🌱🙏 I could speak on this for hours! Lol.

62 3 replies
@ArizonaBaySwimming 2025-06-30

31:50 mins. This must be Mr Hubermans version of a youtube short

61 1 replies
@Nimmins 2025-07-09

I started using weed when I was 14 and smoked chronicly until 1 month and 13 days ago. I used hard drugs such as coke and mdma from 15 to 19 heavily. Im 28 now. Ive struggled with qutting weed more than the hard stuff. Weed has had such a negative impact on my life but im happy that ive made it this far. I thank god im still young and get to live the rest of my life sober.

48 3 replies
@phillipk1258 2025-06-26

Thank God for genuine & caring people like Dr. Anna Lembke. I’ve watched the full episode 3 times this year and get so much out of it. Thank you Dr. H for all your hard work!

47
@VenomB6612 2025-06-26

I use to watch Netflix a lot at night and sometimes play video games. But I realized that these activities are releasing lot of dopamine, so normal activities in the morning feels boring.

36
@RainyDaySprite 2025-06-27

So, engaging in addictive behavior leads to a kind of “dopamine resistance,” similar to the insulin resistance that occurs when one eats too much sugar/carbs/crud. Also, how absolutely beautiful is Dr. Lembke? What a generous, loving, empathic soul.

22

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