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Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

2025-07-24 Science & Technology
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Andrew Huberman
Andrew Huberman
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Description

In this Huberman Lab Essentials episode, my guest is ⁠Dr. Matthew Johnson, PhD⁠, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics. We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries. Episode show notes: https://go.hubermanlab.com/yjsDPfV Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/GzvzWO0NU50 Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Timestamps* 00:00:00 Matthew Johnson; Psychedelics 00:01:44 Different Classes of Psychedelics 00:04:33 Psychedelics & Altering Models 00:06:18 LSD, Psylocibin & Serotonin 00:08:44 Psychedelic Clinical Trials 00:12:28 Therapy, Trust, Psychedelics 00:15:36 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes 00:21:19 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience 00:24:43 Dangers of Psychedelics 00:27:04 Microdosing Psychedelics, Antidepressant 00:31:20 Head Injuries, Psychedelics, Depression Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Top Comments (10)

@Equalizer71 2025-07-24

As a veteran I can say Ayahuasca was one of the best decisions and profound experience in my life. Healed 15+ years of depression and ptsd in 2 nights.

78 4 replies
@hubermanlab 2025-07-24

Thank you for watching! If you enjoyed this topic and episode, please click the “Like” button and subscribe to our channel on YouTube. Thank you for your interest in science! — Andrew

39 6 replies
@charlesknowler38 2025-07-24

Participated in KAT (ketamine assisted therapy) and it changed my life. Hoping for a future for more therapeutic studies and in the hands of people who legitimately need it

30 2 replies
@daviddragon5257 2025-07-25

Psychedelics allow you to strip memory from perception. They can put you into a headspace where you feel you can see the world/problems with a ‘new’ perspective. If done carefully and correctly, you can solidify that new perspective after the experience, setting a new foundation for recovery moving forward

26
@DrFang_TT 2025-07-24

All of the followers here watching this who have BPD, hear me out. Microdosing psilocybin during therapy will be greatly beneficial to you. Stop eating whole bags just to get high. Just microdose while doing therapy sessions with your therapist and while doing DBT on your own and it will greatly benefit you. Do this consistently and you will see a drastic improvement.

17 1 replies
@ritabonita1604 2025-07-24

Love that psychedelics are getting so much attention lately

12
@olgazavilohhina6854 2025-07-24

¡Hola Profe!Just wanted to express my gratitude to You for educating us on variety of topics.Thank You for all Your hard work and care for all of us.

12
@BLESSINGIII 2025-07-24

Thank you Man, Your videos talk about actual matters rather than useless stuff, hoping to learn more from these perception refinement

10
@patriziathomas5375 2025-07-26

Thank you, Andrew. Your enthusiasm for knowledge, your authenticity, your ability to listen, and your talent for synthesizing ideas into manageable nuggets for the "average" listener are what bring me back each time to your podcast. I admit I have the silliest teenage-girl crush (and I'm waaayyyy past that age). LOL! Seriously, I trust your content (something I, sadly, can say less and less these days about "experts on media") and actively incorporate much of it into my own life as well as share it with friends and loved ones.

6
@We-are-at-war-cw1zj 2025-08-07

ITS THE KEY TO HAPPINESS!!! RESPONSIBLY!!

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