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Peptides: The Science, Uses & Safety | Dr. Abud Bakri

2026-06-01 Science & Technology
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Andrew Huberman
Andrew Huberman
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Description

Dr. Abud Bakri, MD, is a board-certified internal medicine physician and expert in the science and clinical use of peptides. We discuss the history, uses, sourcing and safety of BPC-157, GHK-Cu, pinealon, epithalon, GLP-1s, retatrutide, melanotan and growth hormone-promoting peptides. We discuss the gap that exists between animal and human data and meaningful differences in the sources for different peptides. For those interested in peptides, Dr. Bakri provides a grounded look at the science, risks and uncertainties shaping the field today. Show notes: https://go.hubermanlab.com/LKUoSIM Thank you to our sponsors AG1: ⁠https://drinkag1.com/huberman Eight Sleep: ⁠https://eightsleep.com/huberman Lingo: ⁠https://hellolingo.com/huberman Function: ⁠https://functionhealth.com/huberman LMNT: ⁠https://drinklmnt.com/huberman Huberman Lab Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Abud Bakri Website: https://abudbakri.com Substack: https://abud.substack.com X: https://x.com/AbudBakri Instagram: https://www.instagram.com/Abud_Bakri Threads: https://www.threads.com/@abud_bakri LinkedIn: https://www.linkedin.com/in/abud-bakri-md-a3975a193 YouTube: https://www.youtube.com/@AbudBakri Timestamps 00:00:00 Abud Bakri 00:03:33 What are Peptides?, Receptors 00:06:26 BPC-157, Discovery, Animal Proteins 00:11:19 BPC-157, Animal Data, Regeneration 00:12:27 Sponsors: Eight Sleep & Lingo 00:14:51 BPC-157, Regeneration & Healing, Neurological Effects 00:19:27 Adverse Events, Clinical Trials & Legality of BPC-157 00:29:41 GLPs & Compounding Pharmacy; Peptides & Gray Market 00:35:25 Manufacturing, Compounding Pharmacies, Gray Market, Black Market 00:41:32 Peptides & Tumor Growth?; Angiogenesis 00:45:17 Sponsor: AG1 00:47:01 Pharmaceutical Patents, Clinical Trials for BPC-157, Potential Outcomes 00:54:19 BPC-157 Healing, Patient Experiences 01:01:22 Physician Counsel, FDA Legality, Malpractice 01:07:25 Pinealon, Epithalon, Discovery; Sleep & Cognitive Performance, Risks 01:18:17 Sponsor: Function 01:19:55 Pineal Age Deterioration, Epithalon, Eye Health 01:29:38 Thymus, Age Shrinkage; Thymosin Alpha-1, Immune Function 01:38:13 TB-500; Pet Health; Thymic Peptide Doses, Thymulin, Zinc 01:49:13 Sponsor: LMNT 01:50:33 GHK-Cu (Copper GHK), Collagen 01:55:32 Illness Recovery, Thymic Score, Tool: Blood Test & Immune Cell Counts 02:04:01 Growth Hormone Secretagogues, Age Decline, Cancer Risk, Insulin 02:15:36 GHK-Cu, Topical Cream, Red Light Therapy 02:20:25 GLPs, Discovery, Physical & Cognitive Long-Term Effects, Fertility 02:33:53 Retatrutide; Drug Patents & Nomenclature 02:39:03 Peptides: Women Reproductive Disorders; TBI, Neurologic Effect; Safe Sources 02:45:34 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #hubermanlab #science #health #peptides Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Top Comments (10)

@TalkToMeGoose550 2026-06-03

This was literally the f**king best peptide episode with regards to pure info. Very good from both of you. Good banter, great info.

6
@Rev0lutn76 2026-06-03

This dang near 3hrs & I’m going to have to listen to it at least twice; very info packed!

4
@TheRawDose 2026-06-01

*Key Points to Remember After You Watch The Video. (Thank Me Later):* 1. Peptides are special small proteins that act like messengers in your body to help with things like healing, growth, and sleep (0:03:33). 2. BPC 157 is a famous peptide studied in animals that shows promise for helping guts, muscles, and tendons heal faster (0:06:26). 3. Scientists are still learning how BPC 157 works because it does not seem to have one specific receptor, which makes it a mystery (0:15:40). 4. Many people use peptides they find on the internet, but these are often not tested, not clean, or not what the label says they are (0:29:41). 5. Doctors worry that some peptides might help bad things grow, like tumors, by helping new blood vessels form in the wrong places (0:41:32). 6. There is a huge lack of large, safe tests on humans, so we do not yet know the best doses or long-term risks (0:47:01). 7. Pinealon is a tiny protein that some people use to help them get better quality sleep and feel sharper in their brain (1:07:25). 8. Epithalon is another peptide that scientists think might help protect DNA and keep cells healthy as they get older (1:19:55). 9. Thymosin alpha 1 and other similar peptides are sometimes used to help support a strong immune system (1:29:38). 10. GHK copper is a popular peptide often used in skin creams to help skin look younger by making more collagen (1:50:33). 11. Some new medicines like GLP 1s are very powerful for weight loss and blood sugar, but they need a doctor to watch over you (2:20:25). 12. Retatrutide is a newer, very strong tool for weight management that affects multiple systems in your body at once (2:33:53). 13. Before trying any peptide, you must make sure your basic healthy habits like sleeping well, eating good food, and getting sunlight are already in place (2:43:30). 14. Never buy peptides from random websites, because you could be putting dangerous or fake chemicals into your body (2:42:12). 15. Always talk to a medical doctor who knows about your health before thinking about using any kind of peptide (2:43:44). 16. We need better naming rules and more honest studies so that everyone knows exactly what they are taking and why (2:37:21).

211 9 replies
@unreactive 2026-06-01

hey that's my twitter doctor!

81 1 replies
@josemarquez7978 2026-06-03

This was awesome! Loved hearing about the data, which interested me in wanting to get a PHD and run tests myself

2
@openyoeyes1 2026-06-02

Pinealon in the morning has not only increased my REM and Deep sleep, but has had a noticeable positive impact on my mood, thinking, cognition and calmness. It feels like an incredible peptide!!

6
@MichaelangelaFL 2026-06-03

Definitely want to hear podcast part 2! 🙏🏻

4
@mikaelkolozsy2408 2026-06-01

I love how I just decided to go down the research rabbit hole of peptides yesterday, and then this video drops.

46 1 replies
@CashCultura 2026-06-03

2:29:45 been on Reta for a while now, the most important two aspects is hydrating A TON! Second is ensuring you have proper carbohydrate intake and you will feel great

5
@bastiencartaillac4243 2026-06-02

As a french listening to this, I though my yt parameters where on x2 speed... but no bro is just too fast I feel proud to still understand lol

62 12 replies

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