This Compound Kills Cortisol Faster than Anything We’ve Seen (Neuroscientist Reveals)
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Exogenous Ketones: Mechanisms for Anxiety Relief and Critical Safety Warnings
Discover how supplemental ketones acutely reduce anxiety via neurological pathways and learn critical safety distinctions between ketone sources to protect your liver and metabolic health.
Short Summary
- Research confirms exogenous ketones significantly attenuate fear responses and improve social behavior in animal studies within hours of administration.
- The optimal acute combination identified for reducing anxiety was ketone salts paired with MCT oil, outperforming pure ketone esters.
- High blood ketone levels (above 2 mM) may become anxiogenic; the therapeutic sweet spot is 1–2 mM.
- A major risk exists with 1,3-Butanediol (1,3-BD) ketone supplements, which metabolize like alcohol and can compromise liver NAD/ATP levels.
This discussion details the multifaceted mechanisms—including improved brain energy, GABA elevation, and adenosine signaling—by which therapeutic ketosis impacts mental health. Dr. D'Agostino emphasizes that this potent intervention is effective independent of dietary restriction, but strongly advises readers on which commercial sources to avoid to prevent liver toxicity and potential dependency.
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Top Comments (10)
Ketone salts and MCTs
I can confirm, many years ago after my DR? tried to put me on Prosac for severe anxiety, I did the Atkins diet and my anxiety disappeared like magic.
Being in ketosis has supported my alcohol addiction recovery.
Really do enjoy these long-form discussions that get deep into the science behind therapeutic options
Amazing guest! Thank you so much for this interview and for having him on!!
Ok, was not expecting this mind blowing research going way beyond health topics, right out of the gate. Just wow! Just press play and watch this!❤🎉🎉🎉
This is the whole reason why the kid ketogenic diet was used for seizure, patients or epileptic patients
Very timely. On my own journey with 16/8 IF, i see a huge decrease in stress response during the last 4 hours of fasting. I know the ketones are elevated and reducing my stress load. Confirmed by Garmin body battery score and graphics.
I, seemingly for the modern and normal reasons alone, would’ve probably liked it better to also misspell ‘complain’ as ‘comment’ and yet, this has been a brilliant episode! I’ve had to slow it down and write it down and check it out a couple of times already. Such good stuff you get after these days, Tom.
I just wanted to take a moment to write a sincere thank you for this incredible video! 🌟 Honestly, in a sea of content, this really stood out to me because of the sheer quality and depth you provided. It is so rare to find a creator who can balance being informative while keeping the video so entertaining and easy to digest. 🧠✨ I particularly loved the section where you explained [thay thế bằng 1 điểm bạn thích trong video]—that was a total 'lightbulb moment' for me and answered questions I didn’t even know I had! 💡 The editing was also seamless and kept me engaged the entire time. You clearly put a lot of heart into your work, and it shows. I’m definitely turning on notifications because I don’t want to miss what you create next. Do you think you might cover [gợi ý một chủ đề liên quan] in the future? I’d love to hear your take on it! Keep crushing it! 🚀🔥👏
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Top Comments (10)
Ketone salts and MCTs
I can confirm, many years ago after my DR? tried to put me on Prosac for severe anxiety, I did the Atkins diet and my anxiety disappeared like magic.
Being in ketosis has supported my alcohol addiction recovery.
Really do enjoy these long-form discussions that get deep into the science behind therapeutic options
Amazing guest! Thank you so much for this interview and for having him on!!
Ok, was not expecting this mind blowing research going way beyond health topics, right out of the gate. Just wow! Just press play and watch this!❤🎉🎉🎉
This is the whole reason why the kid ketogenic diet was used for seizure, patients or epileptic patients
Very timely. On my own journey with 16/8 IF, i see a huge decrease in stress response during the last 4 hours of fasting. I know the ketones are elevated and reducing my stress load. Confirmed by Garmin body battery score and graphics.
I, seemingly for the modern and normal reasons alone, would’ve probably liked it better to also misspell ‘complain’ as ‘comment’ and yet, this has been a brilliant episode! I’ve had to slow it down and write it down and check it out a couple of times already. Such good stuff you get after these days, Tom.
I just wanted to take a moment to write a sincere thank you for this incredible video! 🌟 Honestly, in a sea of content, this really stood out to me because of the sheer quality and depth you provided. It is so rare to find a creator who can balance being informative while keeping the video so entertaining and easy to digest. 🧠✨ I particularly loved the section where you explained [thay thế bằng 1 điểm bạn thích trong video]—that was a total 'lightbulb moment' for me and answered questions I didn’t even know I had! 💡 The editing was also seamless and kept me engaged the entire time. You clearly put a lot of heart into your work, and it shows. I’m definitely turning on notifications because I don’t want to miss what you create next. Do you think you might cover [gợi ý một chủ đề liên quan] in the future? I’d love to hear your take on it! Keep crushing it! 🚀🔥👏