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This Compound Kills Cortisol Faster than Anything We’ve Seen (Neuroscientist Reveals)

2025-12-06 People & Blogs
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Thomas DeLauer
Thomas DeLauer
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Exogenous Ketones: Mechanisms for Anxiety Relief and Critical Safety Warnings

Discover how supplemental ketones acutely reduce anxiety via neurological pathways and learn critical safety distinctions between ketone sources to protect your liver and metabolic health.

Short Summary

  • Research confirms exogenous ketones significantly attenuate fear responses and improve social behavior in animal studies within hours of administration.
  • The optimal acute combination identified for reducing anxiety was ketone salts paired with MCT oil, outperforming pure ketone esters.
  • High blood ketone levels (above 2 mM) may become anxiogenic; the therapeutic sweet spot is 1–2 mM.
  • A major risk exists with 1,3-Butanediol (1,3-BD) ketone supplements, which metabolize like alcohol and can compromise liver NAD/ATP levels.

This discussion details the multifaceted mechanisms—including improved brain energy, GABA elevation, and adenosine signaling—by which therapeutic ketosis impacts mental health. Dr. D'Agostino emphasizes that this potent intervention is effective independent of dietary restriction, but strongly advises readers on which commercial sources to avoid to prevent liver toxicity and potential dependency.

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Description

Join Thrive Market Today to get 30% Off Your First Order AND a Free Gift Worth up to $60! http://ThriveMarket.com/ThomasDeLauer Recommended Ketone Salts: https://share.google/BtSL9JlH7tRdLPycD Dom's Website: https://ketonutrition.org/ Be sure to check out the Metabolic Health Initiative (MHI): https://www.metabolicinitiative.com/ Follow Dom on Instagram: https://www.instagram.com/dominic.dagostino.kt/ This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. Click HERE to Subscribe: https://www.youtube.com/c/ThomasDeLauerOfficial?sub_confirmation=1 Please check out the new Shorts channel, DeLauer Clips and Workouts, here: https://www.youtube.com/channel/UCQPQImPsw74KhO0Zy2-leyA/videos Please Subscribe to my Email Newsletter Here: https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer Timestamps ⏱ 0:00 - Intro 0:11 - Exogenous Ketones for Anxiety 4:11 - 30% Off Your First Order AND a Free Gift Worth up to $60 4:48 - Exogenous Ketones for Anxiety 7:50 - How Exogenous Ketones Can Alleviate Anxiety 15:04 - Why Metabolic Health Affects Mental Health 17:07 - Dom's Ketones Discovery 19:45 - What Happens When You Consume Alcohol 22:26 - Exogenous Ketones to Mitigate Alcohol Use Disorder 25:38 - Guide to Shopping for Ketones + Dosing 41:18 - Where to Find More of Dom

Top Comments (10)

@chainer2322 2025-12-06

Ketone salts and MCTs

217 11 replies
@l27tester 2025-12-06

Why is it so hard to get to the damm point?

131 21 replies
@jerrylclement 2025-12-06

I can confirm, many years ago after my DR? tried to put me on Prosac for severe anxiety, I did the Atkins diet and my anxiety disappeared like magic.

43
@JackieHilmer 2025-12-06

Being in ketosis has supported my alcohol addiction recovery.

39 4 replies
@scottc7764 2025-12-06

Really do enjoy these long-form discussions that get deep into the science behind therapeutic options

12
@ayrtongraham 2025-12-06

Amazing guest! Thank you so much for this interview and for having him on!!

11
@pjaworek6793 2025-12-06

Ok, was not expecting this mind blowing research going way beyond health topics, right out of the gate. Just wow! Just press play and watch this!❤🎉🎉🎉

9
@Ricky-Zarate 2025-12-07

This is the whole reason why the kid ketogenic diet was used for seizure, patients or epileptic patients

4
@robertmckay2274 2025-12-06

I, seemingly for the modern and normal reasons alone, would’ve probably liked it better to also misspell ‘complain’ as ‘comment’ and yet, this has been a brilliant episode! I’ve had to slow it down and write it down and check it out a couple of times already. Such good stuff you get after these days, Tom.

1
@lilreno1694 2026-01-08

mct oil give me heart palps, what does that mean?

0

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