15g Creatine MEGADOSE Nearly Hospitalizes Pro Golfer (here’s what happened)
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Analyzing Creatine Overdose Claims and Optimal Dosing Strategies
Determine if creatine overdose is a realistic threat and learn the fastest way to leverage large doses for acute cognitive benefits, like overcoming sleep deprivation.
Short Summary
- High-dose creatine ingestion may cause temporary jitteriness or gastrointestinal distress, but major overdose is likely related to hydration shifts or transient neurotransmitter imbalance, not acute toxicity.
- Recent controlled trials confirm that single doses up to 20-25g are safe, often improving outcomes like cognitive decline associated with sleep loss.
- Optimize timing by taking large doses when sleep-deprived or before exercise; micro-dose during sustained cognitive tasks. This guide unpacks an anecdotal creatine incident, explains the underlying physiological mechanisms (methylation, blood sugar), and provides evidence-based dosing recommendations for peak performance and safety.
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Top Comments (10)
I take 3 5gram scoops per day. That rock is a lot freaking bigger than 15 grams
The dry powder/solid object state of it probably iritated his vagus nerve when it was passing through his esophagus and into his stomach. It creates a major sympathetic response. Guess what else makes you shaky? Adrenaline/epinephrine. I've had this happen to me before, but not with creatine. I think everyone is overthinking this.
Very likely temporary dehydration due to not intaking enough water with such a large dry dose. Despite creatine helping to hydrate the body, it needs enough water while in the digestive system to actually move around and be absorbed. You can cause this with any large dry food/supplement, especially when active. I've caused this in myself several times over the years, not just with creatine but any dry food or supplement. You need to figure out how much water your body needs in order to dissolve and absorb whatever you're taking. Everyone has a slightly different tolerance and needs depending on size and activity. Personally I need roughly one ounce of water per gram of dry intake, whether it's powders or vitamin pills. With medicines I tend to go even a little above that. I dehydrate easily, from observation, faster than the average of someone with me doing the same activity. Be aware of your own personal needs and pay attention to how you feel with varying water intake to supplements volume.
Classic signs of dehydration. Creatine requires water.
I’m not able to work this into my finances, yet. Looking forward to when I can.
@Thomasdelauer you say you can dissolve the creatine and go on sipping it throughout the day, but some say you need to take within minutes after you add it to the water.
Good stuff to know!
Great information!👍
thanks for the info
Thanks, this partially explains why I might wake up in the middle of the night when taking a higher dose of creatine. But I’d be happy to see others’ experiences or scientific explanations.
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Top Comments (10)
I take 3 5gram scoops per day. That rock is a lot freaking bigger than 15 grams
The dry powder/solid object state of it probably iritated his vagus nerve when it was passing through his esophagus and into his stomach. It creates a major sympathetic response. Guess what else makes you shaky? Adrenaline/epinephrine. I've had this happen to me before, but not with creatine. I think everyone is overthinking this.
Very likely temporary dehydration due to not intaking enough water with such a large dry dose. Despite creatine helping to hydrate the body, it needs enough water while in the digestive system to actually move around and be absorbed. You can cause this with any large dry food/supplement, especially when active. I've caused this in myself several times over the years, not just with creatine but any dry food or supplement. You need to figure out how much water your body needs in order to dissolve and absorb whatever you're taking. Everyone has a slightly different tolerance and needs depending on size and activity. Personally I need roughly one ounce of water per gram of dry intake, whether it's powders or vitamin pills. With medicines I tend to go even a little above that. I dehydrate easily, from observation, faster than the average of someone with me doing the same activity. Be aware of your own personal needs and pay attention to how you feel with varying water intake to supplements volume.
Classic signs of dehydration. Creatine requires water.
I’m not able to work this into my finances, yet. Looking forward to when I can.
@Thomasdelauer you say you can dissolve the creatine and go on sipping it throughout the day, but some say you need to take within minutes after you add it to the water.
Good stuff to know!
Great information!👍
thanks for the info
Thanks, this partially explains why I might wake up in the middle of the night when taking a higher dose of creatine. But I’d be happy to see others’ experiences or scientific explanations.