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How to Use Exercise to Improve Your Brain’s Health, Longevity & Performance

2025-01-06 Science & Technology
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Andrew Huberman
Andrew Huberman
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Description

In this episode, I discuss how different forms of exercise impact brain health and performance in both the short and long term. I explain how many of the positive effects of exercise on brain function occur through the action of specific neurochemicals that increase alertness. I also cover how to best time exercise and which specific types of exercise to include in your weekly routine to maximize benefits for your brain. Additionally, I explain how certain types of exercise trigger the release of a hormone from your bones called osteocalcin, as well as brain-derived neurotrophic factor. Together, these substances increase neuroplasticity and enhance learning. The positive effects of exercise on brain oxygenation, blood supply, and fuel utilization are also discussed. Listeners will learn how to design a weekly exercise program that optimizes physical fitness, brain health, longevity, and performance, along with the mechanistic logic behind those recommendations. Find show notes with articles, resources and more: https://go.hubermanlab.com/MNDX54b Pre-order Andrew's upcoming book, Protocols: https://go.hubermanlab.com/protocols *Thank you to our sponsors* AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Maui Nui: https://mauinui.com/huberman *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *More Huberman Lab* Huberman Lab Premium: https://go.hubermanlab.com/premium Huberman Lab Merch: https://go.hubermanlab.com/merch *Timestamps* 00:00:00 Exercise, Brain Health & Performance; Protocols Book 00:04:03 Sponsors: BetterHelp & Helix Sleep 00:06:55 Brain Health, Cardiovascular & Resistance Training 00:11:51 Exercise & Positive Impact on Brain Performance; Arousal 00:18:20 Learning & Arousal 00:23:18 Sponsors: AG1 & David 00:26:01 Exercise & Acute Learning 00:29:16 Tool: High-Intensity Training & Cognitive Flexibility; Over-Training 00:33:32 Long-Term Brain Health; Tool: Exercise “Snacks”, Cognitive Performance 00:36:57 Exercise, Brain & Body Energy, Adrenaline, Norepinephrine 00:44:08 Adrenal “Burnout”?; Exercise to Increase Energy, Adrenaline 00:48:20 Tool: Core, Compound Movements; Mind-Body Connection 00:53:58 Sponsor: Function 00:55:45 Bones, Osteocalcin, BDNF & Hippocampus; Tool: Jump Training 01:01:30 Exercise, Fuel, Multifactorial Pathways; BDNF & Activity 01:05:06 Lactate, Astrocytes & Brain Function; VEGF & Brain Health 01:11:17 Tools: Zone 2, High-Intensity Training, Time Under Tension Training 01:19:54 Sponsor: Maui Nui 01:21:37 Tools: Time Under Tension; Explosive Jumping, Eccentric Control Training 01:25:30 Injury & Exercise, Illness 01:28:09 Sleep; Injury, Sleep-Deprivation & Exercise 01:33:51 SuperAgers, Anterior Mid-Cingulate Cortex, Grit & Persistence 01:42:04 Tool: Embrace Challenges; Deliberate Cold Exposure, Rope Flow 01:47:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter #HubermanLab #Science #Exercise Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Top Comments (10)

@hubermanlab 2025-01-06

Thank you for watching! If you enjoyed this topic and episode, please click the “Like” button and subscribe to our channel on YouTube. Thank you for your interest in science! — Andrew

297 34 replies
@Barsaman75 2025-01-06

Thx Doc. In a house full of teenagers, most of them dealing with bad mental health since the covid lockdowns, and every day i urged, pleaded, begged them to hike, workout, do something else then staring on a screen. Finally my oldest boys are hitting the gym now and feeling fantastic. I hope for everyone that they discover the results of gettng off your arse and get moving. Respect and kind regards from the Netherlands.

235 10 replies
@sudhakarrathaur4834 2025-01-08

1. Slow and long cardiovascular 2. Fast and short Cardiovascular 3. Time tension resistance training 4. Put pressure on bones- example jumping exercise 5. Do something phycologically and physically challenging. Do these above points atleast a week, for maximum brain benifits.

136 2 replies
@ilanagriffith9984 2025-01-07

Dr. Huberman, thank you for being so unselfish and so kind by sharing your knowledge. You have changed my life, you have made such a great impact and have given me so much hope and inspiration to stay strong mentally, physically and spiritually. When I struggle with thoughts keeping me down or waking me up in the middle of the night, I find comfort by listening to you. I cannot thank you enough. I am so grateful for you.

121
@LadyAsmodeus 2025-01-06

I discovered the channel last year spring, when I decided to quit smoking and vaping, and found the episode about nicotine - then through the year, I ended up watching all videos on this channel multiple times, and it changed my life for the better! I quit nicotine, and reducing my daily caffeine intake as well, and I sleep much better! starting the year with going outside immediately every day for some exercise, and it helps fixing my messy sleep routine, and went from waking up after 1pm, to be able to wake up hours earlier~ I'm excited for this year, and gonna watch every new episode! <3

79 2 replies
@hammerheadtamer6449 2025-01-06

Never skip brain day ❗️🗣️💯

76 1 replies
@Nils727 2025-01-06

Key Takeaways from Andrew Huberman’s Discussion on Exercise and Brain Health: Overview: Focus: How exercise impacts brain health, performance, and longevity. Goals: Understand mechanisms and practical applications to enhance brain function through exercise. --- Benefits of Exercise on the Brain: Immediate Effects: Improved brain function in minutes to hours after exercise. Long-Term Effects: Enhanced learning, memory retention, and brain adaptability over days, weeks, and months. Compounding Benefits: Regular exercise leads to cumulative improvements in brain performance and health. --- Types of Exercise Studied: 1. Cardiovascular Exercise: Short Duration, High Intensity: Quick bouts (30 seconds to 4 minutes) of all-out effort, followed by rest. Long Duration, Low Intensity: Steady-state efforts lasting 20–60 minutes. 2. Resistance Training: Builds strength, enhances neuroplasticity, and contributes to brain longevity. --- Mechanisms of Impact: 1. Neurobiological Mechanisms: Increases neurogenesis (growth of new neurons). Enhances synaptic plasticity (connections between neurons). 2. Endocrine-Based Mechanisms: Releases hormones (e.g., endorphins, BDNF) that support brain health and performance. --- Key Findings from Research: Extensive Evidence: Tens of thousands of studies show positive impacts of exercise on the brain. Meta-Analyses: Consistently confirm exercise as beneficial for brain performance and longevity. --- Practical Takeaways: Customizable Exercise Programs: Tailor based on age, health, time availability, and desired brain outcomes. Consistency Matters: Regular exercise compounds over time, leading to greater cumulative benefits. Specific Recommendations: Incorporate both cardiovascular and resistance training for maximum impact. --- Other Insights: Body-Brain Communication: Exercise reveals fascinating ways the brain and body interact. Actionable Tools: Exercise protocols based on modern research are accessible and effective. --- Related Updates: Upcoming Book: Protocols: An Operating Manual for the Human Body (Release: September 2025). Covers actionable steps for improving brain health, sleep, stress, and more.

65 1 replies
@MuhammadMaaz-k3s 2025-01-06

The part about how small changes in daily habits can drastically impact mental and physical health really stood out to me. Definitely something I’ll try to implement!

34 1 replies
@Nešališkas 2025-01-14

I woke up at 5 am, accidentally. Normally I go to sleep at 5 am. Anyways, I thought I will play youtube to fall back to sleep faster, now it’s 6am, I have already had cold shower, I’ve exercised, I’m eating breakfast and getting ready to go to work sharp. Just this video alone already changed my life in a way

23 2 replies
@tinaolson744 2025-01-08

Exercises I despise and commit to not skipping them this year: burpees, mountain climbers at a fast pace, plank jacks and press jacks? See a theme? I do not enjoy sprinting and I will make it happen!

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