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We Spent $724,637 Testing Rapamycin. What We Found Shocked Us.

2026-04-22 People & Blogs
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Dr Brad Stanfield
Dr Brad Stanfield
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Description

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial https://onlinelibrary.wiley.com/doi/10.1002/jcsm.70274 🩺 Get your personalized health plan: https://drstanfield.com/pages/roadmap Timestamps: 00:00 Background of the Rapamycin Study 05:44 Study Design and Protocol 07:33 - Results of the Rapamycin Study 09:29 Interpretation of the Results 26:28 Study Conclusion and Mechanistic Explanations 31:47 Discussion on the Impact of Rapamycin on Exercise 32:41 Discussion on Future Research and Dosing Frequency 💊 Supplements I Take: https://drstanfield.com/pages/my-supplements 💊MicroVitamin+ (Pro) Powder: https://drstanfield.com/products/microvitamin-plus 💊MicroVitamin Standard Capsules: https://drstanfield.com/products/microvitamin ✔️ X: https://x.com/BradStanfieldMD ✔️ Patreon: https://www.patreon.com/bradstanfieldmd Thumbnail by James Kelly Video edited by Troy Young The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Top Comments (10)

@tinahickson6352 2026-04-22

I’m delighted that I had the chance to help in a small way to fund this trial. The results weren’t what we all hoped, but they furthered our knowledge. Thank you!

132 2 replies
@banzaiburger 2026-04-23

Why I respect this channel and Dr Stanfield is because actual science is taking place

83
@DrBradStanfield 2026-04-22

Thank you to everyone who donated to the crowdfunding effort to get this trial done Thank you to all of you, the viewers of this channel, for your support during the past 5 years Thank you for purchasing MicroVitamin, which enabled us to raise the remaining funds for this trial Study link: https://onlinelibrary.wiley.com/doi/10.1002/jcsm.70274

78
@johnnyanglo6709 2026-04-23

You should bottle the placebo and state "Works even Better than Rapamycin!" You'll make a fortune.

67 4 replies
@evertmaree 2026-04-23

You get my respect for reporting a non hype result. This just proves you are authentic and not part of misinformation problem we currently have in world. More respect for your content in future.

50 2 replies
@normanwei529 2026-04-23

Mad cudos for doing this video despite the results not panning out we would have liked them too.❤ Keep doing what you do you're great

24
@MoleChile 2026-04-23

One of the ten most cited papers I worked on was a report of our negative results, it got some positive commentary at the time ( about 20 years ago ), for being a rare case of negative results being reported rigorously. Over time that's turned out to be useful to other researchers.

24
@DrAndrewSteele 2026-04-24

First, massive congratulations to Brad for getting this trial over the line—long-term subscribers (like me!) will know the huge personal effort he went to to get this done! Second, amazing to see such an honest, in-depth discussion of the results by Brad and Matt who are both great scientists and communicators. I am here for this kind of content!

21 1 replies
@tomAlter-ty2bj 2026-04-22

Congratulations, whatever the results the research was amazing and much needed.

15
@michelsamson3689 2026-04-29

First I want to congratulate both Dr. Stanfield and Matt for doing this study. Even though there are no conclusive results it is still an important step. Both my wife and I have taken Dr. Reddy's and Glenmark (5mg/week since 2019) and, based on our own observations, Glenmark has better bioavailability. For whatever it's worth, I'm 82 and working with a trainer and I am still building muscle.

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