We Were Wrong About Aspirin (New Evidence)

🩺 Get your personalized health plan: https://drstanfield.com 💊 Supplements I Take: https://drstanfield.com/pages/my-supplements 💊MicroVitamin+ (Pro) Powder: https://drstanfield.com/products/microvitamin-plus 💊MicroVitamin Standard Capsules: https://drstanfield.com/products/microvitamin ✔️ X: https://x.com/BradStanfieldMD ✔️ Patreon: https://www.patreon.com/bradstanfieldmd Timestamps: 00:00 Aspirin's Initial Success 01:59 Aspirin's Impact on Cancer 03:26 The Unexpected Twist: John McNeill's Observations 00:04:33 The ASPREE Trial 06:12 The Follow-up ASPREE Results 08:05 The Updated Analysis by the Cochrane Library 13:32 The Current State of Aspirin Use Here are the links to the research papers referenced in the video: Rothwell — Daily aspirin and long-term cancer death (Lancet, 2011) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)62110-1/abstract USPSTF 2016 — Aspirin for CVD and colorectal cancer prevention https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016 McNeil — ASPREE: aspirin and all-cause mortality (NEJM, 2018) https://www.nejm.org/doi/10.1056/NEJMoa1803955 Kune — Melbourne Colorectal Cancer Study (1988) https://pubmed.ncbi.nlm.nih.gov/3390835/ Burn — CAPP2 aspirin in Lynch syndrome, 10-year follow-up (Lancet, 2020) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30366-4/fulltext Rothwell — Aspirin and cancer metastasis (Lancet, 2012) https://pubmed.ncbi.nlm.nih.gov/22440947/ Rothwell — Aspirin short-term cancer incidence and mortality, 51 RCTs (Lancet, 2012) https://pubmed.ncbi.nlm.nih.gov/22440946/ ASPREE recruitment — lessons from a 19,114-person GP-led trial https://pmc.ncbi.nlm.nih.gov/articles/PMC6456041/ ASPREE — aspirin, cardiovascular events and bleeding (NEJM, 2018) https://www.nejm.org/doi/10.1056/NEJMoa1805819 Orchard — ASPREE follow-up: cancer incidence and mortality (JAMA Oncology, 2026) https://jamanetwork.com/journals/jamaoncology/article-abstract/2844193 Healio — Orchard interview on the ASPREE follow-up https://www.healio.com/news/hematology-oncology/20260218/lowdose-aspirin-significantly-increases-cancer-mortality-risk-among-older-adults Cai — Cochrane review: aspirin and NSAIDs for colorectal cancer prevention (2026) https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015266.pub2/full USPSTF 2022 — Aspirin for CVD prevention (colorectal cancer withdrawn) https://jamanetwork.com/journals/jama/fullarticle/2791399 University of Cambridge press release — how aspirin could prevent metastasis https://www.cam.ac.uk/research/news/scientists-discover-how-aspirin-could-prevent-some-cancers-from-spreading Yang — Aspirin prevents metastasis via platelet TXA2 and T cell immunity (Nature, 2025) https://www.nature.com/articles/s41586-025-08626-7 McNeil — Aspirin and cancer incidence/mortality in older adults (JNCI, 2021) https://academic.oup.com/jnci/article/113/3/258/5889955 Lynch syndrome — physician compliance and patient uptake with aspirin therapy (2026) https://pubmed.ncbi.nlm.nih.gov/41661407/ Thumbnail by James Kelly Video edited by Troy Young Script by John Milliken The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.