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This Vitamin D Study Forced Me to Change My View

2025-11-26 People & Blogs
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Dr Brad Stanfield
Dr Brad Stanfield
335.0k subscribers

New Vitamin D Research Challenges Current Deficiency Guidelines

A recent, novel trial forces a re-evaluation of standard Vitamin D advice, suggesting targeted supplementation might reduce future heart attacks in high-risk patients.

Short Summary

  • The TARGET-D Trial examined aggressive, individualized Vitamin D dosing in post-heart attack patients, yielding promising (though statistically marginal) results for secondary prevention.
  • Prior large trials failed to show benefits of blanket Vitamin D supplementation, leading guidelines to recommend against routine testing for healthy individuals.
  • This new nuanced approach suggests that while current guidelines might remain, clinicians should consider personalized Vitamin D testing for specific high-risk groups.

This content reviews the shift from observational studies linking low Vitamin D to disease, through broad clinical trial failures, to the specific methodology and cautious implications of the recent TARGET-D trial concerning cardiovascular events.

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Description

For weekly health research summaries and extra insights, sign up here 👉 https://drstanfield.com/pages/sign-up 💊 Supplements I Take: https://drstanfield.com/pages/my-supplements 💊MicroVitamin+ (Pro) Powder: https://drstanfield.com/products/microvitamin-plus 💊MicroVitamin Standard Capsules: https://drstanfield.com/products/microvitamin Timestamps: 00:00 The Shift in Vitamin D Guidelines 01:39 Current Approach to Vitamin D Testing 02:09 The New TARGET-D Trial 06:57 Caveats of the TARGET-D Trial 09:42 How the New Study Changes My Approach 📜 Roadmap - how to look young & feel strong: https://drstanfield.com/pages/roadmap ✔️ Twitter: https://twitter.com/BradStanfieldMD ✔️ Patreon: https://www.patreon.com/bradstanfieldmd Here are the links to the research papers referenced in the video: https://academic.oup.com/jcem/article/109/8/1961/7686350 https://pmc.ncbi.nlm.nih.gov/articles/PMC7089819 https://academic.oup.com/jcem/article/109/8/1907/7685305#522488336 https://eppro02.ativ.me/web/index.php?page=Session&project=AHA25&id=4382525 Thumbnail by James Kelly Video edited by Troy Young Script by John Milliken The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Top Comments (10)

@Who_Me_Yeah_You 2025-11-26

I love how after all these years we still don't have this basic stuff figured out. I guess there's no money in finding out if vitamin D is actually good for you.

248 24 replies
@nd7915 2025-11-27

People have been calling out the fatal flaw in the studies showing no effects for YEARS: that they don't control for levels but rather just administer a blanket dose. Same for Omega-3.

103 23 replies
@carlr2837 2025-11-26

There was a study that showed that high Vitamin D levels was associated with slower growth of prostate cancer.

95 8 replies
@paul407-r9k 2025-11-26

As a provider, it has been frustrating seeing study after study not managing for a goal vit d level, but rather just giving a random dose for everyone. Finally, a more appropriate study was performed!

53 1 replies
@33pds 2025-11-30

i take 50.000 units per day it's been 6 years. my health is tops I look amazing

29 6 replies
@DrBradStanfield 2025-11-25

All 4 studies referenced in the video are linked in the video's description 💊Supplements that Dr Brad takes: https://drstanfield.com/pages/my-supplements 💊MicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin For extra insights + a free health checklist, sign up here 👉 https://drstanfield.com/pages/sign-up

19 16 replies
@Smamb76 2026-03-21

Been taking 5000 for 20 years got tested for the first time ever just to see. The test range was 35 to95 in the U.S mine was right in the middle at 65 . I very rarely get sick never had covid either am 68.

17
@iAnasazi 2025-11-29

The more important question is: Why are low quality studies still a thing? Like, at all?

16 4 replies
@heatherwurzer5707 2026-02-12

I would think a study of Vit D WITH Vit K2 would be very important, especially in regards to cardiac health.

6
@CJRSTV 2025-12-02

Love that you always provide the nuance, thank you for providing this valuable information and all the caveats you're aware of!

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