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This Vitamin D Study Forced Me to Change My View

2025-11-26 People & Blogs
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Dr Brad Stanfield
Dr Brad Stanfield
329.0k subscribers

New Vitamin D Research Challenges Current Deficiency Guidelines

A recent, novel trial forces a re-evaluation of standard Vitamin D advice, suggesting targeted supplementation might reduce future heart attacks in high-risk patients.

Short Summary

  • The TARGET-D Trial examined aggressive, individualized Vitamin D dosing in post-heart attack patients, yielding promising (though statistically marginal) results for secondary prevention.
  • Prior large trials failed to show benefits of blanket Vitamin D supplementation, leading guidelines to recommend against routine testing for healthy individuals.
  • This new nuanced approach suggests that while current guidelines might remain, clinicians should consider personalized Vitamin D testing for specific high-risk groups.

This content reviews the shift from observational studies linking low Vitamin D to disease, through broad clinical trial failures, to the specific methodology and cautious implications of the recent TARGET-D trial concerning cardiovascular events.

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Description

For weekly health research summaries and extra insights, sign up here 👉 https://drstanfield.com/pages/sign-up 💊 Supplements I Take: https://drstanfield.com/pages/my-supplements 💊MicroVitamin+ (Pro) Powder: https://drstanfield.com/products/microvitamin-plus 💊MicroVitamin Standard Capsules: https://drstanfield.com/products/microvitamin Timestamps: 00:00 The Shift in Vitamin D Guidelines 01:39 Current Approach to Vitamin D Testing 02:09 The New TARGET-D Trial 06:57 Caveats of the TARGET-D Trial 09:42 How the New Study Changes My Approach 📜 Roadmap - how to look young & feel strong: https://drstanfield.com/pages/roadmap ✔️ Twitter: https://twitter.com/BradStanfieldMD ✔️ Patreon: https://www.patreon.com/bradstanfieldmd Here are the links to the research papers referenced in the video: https://academic.oup.com/jcem/article/109/8/1961/7686350 https://pmc.ncbi.nlm.nih.gov/articles/PMC7089819 https://academic.oup.com/jcem/article/109/8/1907/7685305#522488336 https://eppro02.ativ.me/web/index.php?page=Session&project=AHA25&id=4382525 Thumbnail by James Kelly Video edited by Troy Young Script by John Milliken The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Top Comments (10)

@Who_Me_Yeah_You 2025-11-26

I love how after all these years we still don't have this basic stuff figured out. I guess there's no money in finding out if vitamin D is actually good for you.

206 18 replies
@Shoutatclouds 2025-11-26

I wonder why they don't include k2

140 61 replies
@nd7915 2025-11-27

People have been calling out the fatal flaw in the studies showing no effects for YEARS: that they don't control for levels but rather just administer a blanket dose. Same for Omega-3.

92 9 replies
@carlr2837 2025-11-26

There was a study that showed that high Vitamin D levels was associated with slower growth of prostate cancer.

84 7 replies
@ewinbarnett9411 2025-11-26

During the Covid Debacle, it was shown to my satisfaction at least that there was a good correlation between the level of 25-hydroxy D and severe outcomes during a Covid infection.

49 9 replies
@paul407-r9k 2025-11-26

As a provider, it has been frustrating seeing study after study not managing for a goal vit d level, but rather just giving a random dose for everyone. Finally, a more appropriate study was performed!

48 1 replies
@Quickdraw1111 2025-12-08

Dr. Stanfield, what about the famous study published on October 20, 2014 by Paul J. Veuggelers and John Paul Ekwaru? It found that there was a statistical error / miscalculation in the data that led to the government recommended daily 600 IU of vitamin D. The study says when adjusting for the error, instead of 600 IU, we should be taking 8,895 IU of vitamin D per day! Have you ever talked about this study or any videos about it? Isn't this a critical issue to address?

32 7 replies
@ronenen 2025-11-27

The reason i take high dosage of vitamin d + k2 for immune system modulation.

26 7 replies
@DrBradStanfield 2025-11-25

All 4 studies referenced in the video are linked in the video's description 💊Supplements that Dr Brad takes: https://drstanfield.com/pages/my-supplements 💊MicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin For extra insights + a free health checklist, sign up here 👉 https://drstanfield.com/pages/sign-up

18 14 replies
@lobba123 2025-11-28

i just keep my levels around 100ng/ml and take all cofactors and i feel well, science is so corrupted these days that i trust no studies, i will be my own trial and study and test directly on me

18 3 replies

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