Dementia Rates PLUNGED in Study of 1 Million People
Cholesterol, Statins, and Modifiable Dementia Risk Factors
Discover why managing blood cholesterol is now considered a key modifiable risk factor for dementia and learn lifestyle changes that support long-term cognitive resilience.
Short Summary
- Long-term cholesterol management, especially using medications starting younger, shows potential for significant dementia risk reduction based on genetic mimicry studies.
- Traditional Randomized Control Trials (RCTs) often fail to capture long-term benefits seen in observational studies due to trial duration limits.
- Untreated sensory deficits (hearing/vision loss) and midlife depression emerge as major, actionable dementia risk factors ranking highly alongside cholesterol.
- A key takeaway is that treating depression, sensory loss, and managing lifestyle factors (inactivity, obesity) directly lowers your cognitive risk profile.
This presentation reviews the conflicting data regarding statins and brain health, highlighting the strong evidence supporting cholesterol management for dementia prevention. It then pivots to actionable, non-medication risk reduction strategies identified by recent commissions. Readers gain clarity on research limitations and concrete steps to protect long-term cognitive function.
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Top Comments (10)
After taking cholesterol lowering medication (atorvastatin) for 3 years, I started noticing forgetfulness become significant. I started feeling difficulty recalling the names of the people and items. Specially it was higher in the morning. I was taking statin before sleep. My suspicion went towards atorvastatin. So I stopped taking it without informing the doctor. As per my suspicion, I started feeling better after a week. So I complained to the doctor and changed it to pitavastatin. But the forgetfulness and brain fog again became more. I complained to the doctor again and he changed to rasuvastatin. But the results were the same. So I took my own decision and stopped taking statins. I am off statins from last two years. My memory and brain fog improved significantly. But not fully recovered. I will not take statins again.
My summary: I don't recall him saying clearly WHY dementia rates plunged. What he did say was that people born with a gene that acts to reduce LDL, similar to the way a statin does, are less likely to have dementia. So it is a way to think of the LONG TERM protective effect of statin (hard to study in short study). Also said that keeping mind active is a way to reduce dementia, as is correcting hearing problems and vision problems (brain connections atrophy with loss of constant sensory input). Also said that Creatine (5g/day) and TMG supplements (1g/day?) are good for the brain.
Only a relative risk reduction in an area of total confusion. Diet and exercise are part of the answer.
All 21 studies referenced in the video are linked in the video's description 💊Supplements that Dr Brad takes: https://drstanfield.com/pages/my-supplements 💊MicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin For extra insights + a free health checklist, sign up here 👉 https://drstanfield.com/pages/sign-up
Tried a statin - went in to severe depression 3 days in. Found a report of 14 case studies from 2016 of other people who had had the same problem. Quite after 6 weeks and came out of depression a week later. I realize that 14 cases out of the millions on statins suggest this is a rare phenomenon but maybe no one is looking? Whatever, it worked for me as N=1 so whatever. Definitely something going on in my brain, at least.
Ok, continue to "do the trials and research"... fine But when big pharma doesn't get the answer they want, they can't just shove the whole study in their drawer. I moved and changed primary care doctors. They knew I wasn't fasting, but sent me downstairs for the lipid panel blood draw. I'd just come to the appointment from having lunch with friends... 5 Guys 2 cheese burgers 55min before the draw. Yep, their advise was to put me on a statin. I next went to a new Cardiologist who just looked briefly at my cholesterol and said they don't need me to start the statin. They understood my goals are to 1) drop weight to get off my bad knee so I can be more successful comfortably walk and exercise, 2) seriously attack my insulin resistance (so the weight loss is achieved) and lower bodily inflammation. Cardiologist said those 2 are the grand-slam for me and that Statins DO NOT HELP with me achieve either of those goals. Matter-of-fact, there is solid evidence statins are detrimental to addressing the insulin management. Don't let them dictate your treatment, starting statins, just so their clinic achieves a prescription quota and they get the $$ from the Pharma corruption(s)
Always think how humans are designed to live through history - exercise, time outdoors, mapping where you are outside, dealing with uneven terrain, thinking through problems, interacting or working with others, eating naturally, not eating 6 times a day etc etc
This is great information I have been on lipitor for years, exercised throughout my military career and I still do daily at 68 and do try to eat low fat. I had heard Lipitor increased risk, it is a relief to know it actually helps. I also monitor my blood sugar and last lab had A1C in the 5 range👍 Thanks Dr Stanfield. Also taking zetia…
It is very important to know who funded each study and also any other sources of Conflict o interest.
Now that's what I call a good video. Thank you.
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Top Comments (10)
After taking cholesterol lowering medication (atorvastatin) for 3 years, I started noticing forgetfulness become significant. I started feeling difficulty recalling the names of the people and items. Specially it was higher in the morning. I was taking statin before sleep. My suspicion went towards atorvastatin. So I stopped taking it without informing the doctor. As per my suspicion, I started feeling better after a week. So I complained to the doctor and changed it to pitavastatin. But the forgetfulness and brain fog again became more. I complained to the doctor again and he changed to rasuvastatin. But the results were the same. So I took my own decision and stopped taking statins. I am off statins from last two years. My memory and brain fog improved significantly. But not fully recovered. I will not take statins again.
My summary: I don't recall him saying clearly WHY dementia rates plunged. What he did say was that people born with a gene that acts to reduce LDL, similar to the way a statin does, are less likely to have dementia. So it is a way to think of the LONG TERM protective effect of statin (hard to study in short study). Also said that keeping mind active is a way to reduce dementia, as is correcting hearing problems and vision problems (brain connections atrophy with loss of constant sensory input). Also said that Creatine (5g/day) and TMG supplements (1g/day?) are good for the brain.
Only a relative risk reduction in an area of total confusion. Diet and exercise are part of the answer.
All 21 studies referenced in the video are linked in the video's description 💊Supplements that Dr Brad takes: https://drstanfield.com/pages/my-supplements 💊MicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin For extra insights + a free health checklist, sign up here 👉 https://drstanfield.com/pages/sign-up
Tried a statin - went in to severe depression 3 days in. Found a report of 14 case studies from 2016 of other people who had had the same problem. Quite after 6 weeks and came out of depression a week later. I realize that 14 cases out of the millions on statins suggest this is a rare phenomenon but maybe no one is looking? Whatever, it worked for me as N=1 so whatever. Definitely something going on in my brain, at least.
Ok, continue to "do the trials and research"... fine But when big pharma doesn't get the answer they want, they can't just shove the whole study in their drawer. I moved and changed primary care doctors. They knew I wasn't fasting, but sent me downstairs for the lipid panel blood draw. I'd just come to the appointment from having lunch with friends... 5 Guys 2 cheese burgers 55min before the draw. Yep, their advise was to put me on a statin. I next went to a new Cardiologist who just looked briefly at my cholesterol and said they don't need me to start the statin. They understood my goals are to 1) drop weight to get off my bad knee so I can be more successful comfortably walk and exercise, 2) seriously attack my insulin resistance (so the weight loss is achieved) and lower bodily inflammation. Cardiologist said those 2 are the grand-slam for me and that Statins DO NOT HELP with me achieve either of those goals. Matter-of-fact, there is solid evidence statins are detrimental to addressing the insulin management. Don't let them dictate your treatment, starting statins, just so their clinic achieves a prescription quota and they get the $$ from the Pharma corruption(s)
Always think how humans are designed to live through history - exercise, time outdoors, mapping where you are outside, dealing with uneven terrain, thinking through problems, interacting or working with others, eating naturally, not eating 6 times a day etc etc
This is great information I have been on lipitor for years, exercised throughout my military career and I still do daily at 68 and do try to eat low fat. I had heard Lipitor increased risk, it is a relief to know it actually helps. I also monitor my blood sugar and last lab had A1C in the 5 range👍 Thanks Dr Stanfield. Also taking zetia…
It is very important to know who funded each study and also any other sources of Conflict o interest.
Now that's what I call a good video. Thank you.