The 60-Year Cholesterol War Is Finally Over

🩺 Get your personalized health plan: https://drstanfield.com/pages/roadmap 💊 Supplements I Take: https://drstanfield.com/pages/my-supplements 💊MicroVitamin+ (Pro) Powder: https://drstanfield.com/products/microvitamin-plus 💊MicroVitamin Standard Capsules: https://drstanfield.com/products/microvitamin ✔️ X: https://x.com/BradStanfieldMD ✔️ Patreon: https://www.patreon.com/bradstanfieldmd Timestamps: 00:00 The Dallas Heart Study and PCSK9 02:58 The Fourier Trial 03:34 The VESALIUS-CV Trial 08:21 The Case for Lower LDL Targets 08:26 The Ez-PAVE Study 10:13 The PESA Study 11:53 The Underutilization of Ezetimibe 13:22 Conclusion and Future Directions Here are the links to the research papers referenced in the video: 1. doi: 10.1001/jama.2026.3277 https://jamanetwork.com/journals/jama/fullarticle/2847162 VESALIUS-CV Diabetes Subgroup Analysis — JAMA 2026 2. doi: 10.1172/JCI84086 https://pmc.ncbi.nlm.nih.gov/articles/PMC4607136/ JCI Conversation with Helen Hobbs — 2015 3. doi: 10.1056/NEJMoa054013 https://www.nejm.org/doi/full/10.1056/NEJMoa054013 Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease — NEJM 2006 4. doi: 10.3389/fcvm.2021.764038 https://pmc.ncbi.nlm.nih.gov/articles/PMC8589637/ Regulation of PCSK9 Expression and Function: Mechanisms and Therapeutic Implications — Frontiers in Cardiovascular Medicine 2021 5. doi: 10.1016/j.jacc.2012.08.986 https://www.jacc.org/doi/10.1016/j.jacc.2012.08.986 Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels — JACC 2012 6. doi: 10.1056/NEJMoa1615664 https://www.nejm.org/doi/full/10.1056/NEJMoa1615664 Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease (FOURIER) — NEJM 2017 7. doi: 10.1056/NEJMoa2514428 https://www.nejm.org/doi/full/10.1056/NEJMoa2514428 Evolocumab in Patients without a Previous Myocardial Infarction or Stroke (VESALIUS-CV) — NEJM 2025 8. https://www.acc.org/About-ACC/Press-Releases/2026/03/28/15/33/Evolocumab-Cuts-Cardiac-Risk-in-Patients-Without-Known-Atherosclerosis-and-With-Diabetes Evolocumab Cuts Cardiac Risk in Patients Without Known Atherosclerosis and With Diabetes — ACC Press Release, March 2026 9. https://www.peoplespharmacy.com/articles/woman-has-heart-attack-despite-very-low-cholesterol Woman Has Heart Attack Despite Very Low Cholesterol — People's Pharmacy 10. doi: 10.1016/j.ahj.2008.08.010 https://pubmed.ncbi.nlm.nih.gov/19081406/ Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines — American Heart Journal 2009 11. doi: 10.1056/NEJMoa2600283 https://www.nejm.org/doi/full/10.1056/NEJMoa2600283 Ez-PAVE Trial — NEJM 2026 12. https://www.tctmd.com/news/very-low-ldl-levels-best-secondary-prevention-ez-pave Very Low LDL Levels Best in Secondary Prevention: Ez-PAVE — TCTMD (Cannon + Aspry quotes) 13. doi: 10.1016/j.jacc.2017.10.024 https://www.jacc.org/doi/10.1016/j.jacc.2017.10.024 Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors (PESA) — JACC 2017 14. doi: 10.1177/11772719241257410 https://pmc.ncbi.nlm.nih.gov/articles/PMC11143858/ Are We Using Ezetimibe As Much As We Should? — Therapeutic Advances in Cardiovascular Disease 2024 15. doi: 10.1001/jama.2025.20620 https://jamanetwork.com/journals/jama/article-abstract/2841258 Efficacy and Safety of Oral PCSK9 Inhibitor Enlicitide in Adults With Heterozygous Familial Hypercholesterolemia — JAMA 2025 16. https://www.utsouthwestern.edu/newsroom/articles/year-2026/march-cholesterol-guideline-shifts-focus-earlier-prevention.html Updated cholesterol guideline shifts focus to earlier prevention — UT Southwestern Newsroom, March 2026 (Rohatgi quote) 17. doi: 10.1016/j.jacc.2012.09.017 https://www.jacc.org/doi/10.1016/j.jacc.2012.09.017 Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease — JACC 2012 Thumbnail by James Kelly Video edited by Troy Young Script by John Milliken The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.