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New Study Says I Was Wrong About NMN and NR?

2026-04-03 People & Blogs
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Dr Brad Stanfield
Dr Brad Stanfield
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For weekly health research summaries and extra insights, sign up here πŸ‘‰ https://drstanfield.com/pages/sign-up πŸ’Š Supplements I Take: https://drstanfield.com/pages/my-supplements πŸ’ŠMicroVitamin+ (Pro) Powder: https://drstanfield.com/products/microvitamin-plus πŸ’ŠMicroVitamin Standard Capsules: https://drstanfield.com/products/microvitamin 🩺 Get your personalized health roadmap (free): https://drstanfield.com/pages/roadmap Timestamps: 00:00 The Discovery of Nicotinamide Riboside 01:22 NR vs NMN Debate 02:24 The New NR vs NMN (Bergen) Study 03:15 The Contradictory NR vs NN Nature Metabolism Study 03:51 The Hidden Truth in the Bervin Data 06:37 The Evidence Against NR and NMN 09:38 Conclusion & Key Takeaways βœ”οΈ X: https://x.com/BradStanfieldMD βœ”οΈ Patreon: https://www.patreon.com/bradstanfieldmd Here are the links to the research papers referenced in the video: https://link.springer.com/article/10.1007/s11357-023-01011-0 β€” Astaxanthin/meclizine extend lifespan (ITP 2023) https://ax3.life/ β€” AX3 supplement marketing claim https://rejuvant.com/ β€” Rejuvant AKG supplement https://www.globenewswire.com/news-release/2023/03/28/2635803/0/en/67-Year-Old-Founder-of-Ponce-De-Leon-Health-Achieves-Longevity-Escape-Velocity-with-Rejuvant.html β€” "Longevity escape velocity" press release https://link.springer.com/article/10.1007/s11357-026-02201-2 β€” ITP 2026 results (astaxanthin, AKG, etc. all fail) https://www.nia.nih.gov/research/dab/interventions-testing-program-itp β€” ITP program page https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/about-itp β€” About the ITP https://www.science.org/doi/10.1126/science.aaf2693 β€” NR extends lifespan in mice (Zhang 2016) https://pmc.ncbi.nlm.nih.gov/articles/PMC8135004/ β€” NR fails in ITP https://pmc.ncbi.nlm.nih.gov/articles/PMC9494524/ β€” Rapamycin discovery history (Easter Island) https://www.nature.com/articles/nature08221 β€” Rapamycin extends lifespan (ITP 2009) https://www.science.org/doi/10.1126/science.326.5960.1600 β€” Science "Runners-Up" 2009 https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/supported-interventions β€” ITP supported interventions list https://pmc.ncbi.nlm.nih.gov/articles/PMC8508957/ β€” AKG extends lifespan (Buck Institute 2020) https://www.buckinstitute.org/news/a-metabolite-produced-by-the-body-increases-lifespan-and-dramatically-compresses-late-life-morbidity-in-mice/ β€” Lithgow "nightmare scenario" quote https://x.com/davidasinclair/status/1300868036023459841 β€” Sinclair AKG tweet https://www.aging-us.com/article/203736/text β€” Rejuvant 8-year biological age claim study https://www.mdpi.com/2673-8856/5/2/28 β€” Horvath clock comparison (TruAge error margin) https://www.nature.com/articles/nature05354 β€” Resveratrol in mice (Sinclair 2006) https://www.fiercebiotech.com/biotech/glaxosmithkline-gsk-to-acquire-sirtris-pharmaceuticals-a-world-leader-sirtuin-research-and β€” GSK acquires Sirtris for $720M https://pmc.ncbi.nlm.nih.gov/articles/PMC2832984 β€” Resveratrol not a direct SIRT1 activator https://www.fiercebiotech.com/biotech/safety-concerns-force-glaxo-to-suspend-enrollment-srt501-trial β€” SRT501 kidney damage trial halt https://www.bioworld.com/articles/438084 β€” GSK closes Sirtris https://www.levels.com/blog/matt-kaeberlein-longevity-science β€” Kaeberlein "most debunked" quote https://pmc.ncbi.nlm.nih.gov/articles/PMC8472736/ β€” Astaxanthin skin meta-analysis Thumbnail by James Kelly Video edited by Troy Young Script by John Milliken The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Top Comments (10)

@JP-AT 2026-04-03

67yo, very fit, I found absolutely no physical benefit from taking NMN and NR (for 1 year) apart from a blood test showing dramatically increased NAD+. (For whatever thats worth). I started taking 500mg niacin which also increased NAD+ but for $4/mo - again - for whatever thats worth.

94 42 replies
@joemurray8902 2026-04-03

Absolutely brilliant! Thank you Dr. Brad!

34
@MacSledge_1 2026-04-04

We really need a man like you who tells us the truth.

20
@timwilliams9100 2026-04-03

I changed to niacin years ago. I have photo damaged skin. It reduces the amount of pre skin cancer by 50 percent and skin cancer by 25%.

16 2 replies
@thomasfurman6052 2026-04-03

I'm still taking MNM but data over the last few years, as you stated, is telling me it's a waste. Wow and thanks.

14 2 replies
@DrBradStanfield 2026-04-03

All 15 studies referenced in the video are linked in the video's description πŸ’ŠSupplements that Dr Brad takes: https://drstanfield.com/pages/my-supplements πŸ’ŠMicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin 🩺 Get your personalized health roadmap from Dr Brad: https://drstanfield.com/pages/roadmap

11 9 replies
@TronJockey 2026-04-03

Sadly, in our modern world, telling the truth is often less profitable than selling snake oil. Thanks for staying the course in pursuit of the truth Dr. Stanfield.

11 2 replies
@potsofstew1369 2026-04-03

Saw Sinclair on a podcast recently where he revealed, along with his daily dose of NMN, he takes very high doses of vit B3 - now we know why, & that he too knows he's selling snake oil. Thanks for the update, Doc

10
@SRD-n4m 2026-04-03

You are the "James Bond" of medicine. Love your investigation skills! Thank you for your passion and for sharing your knowledge with us.

7
@charleskaminski221 2026-04-03

We really need a measure of epigenetic changes before closing the book on NAD precursors

5

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