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New Study Says I Was Wrong About NMN and NR?

2026-04-03 People & Blogs
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Dr Brad Stanfield
Dr Brad Stanfield
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For weekly health research summaries and extra insights, sign up here πŸ‘‰ https://drstanfield.com/pages/sign-up πŸ’Š Supplements I Take: https://drstanfield.com/pages/my-supplements πŸ’ŠMicroVitamin+ (Pro) Powder: https://drstanfield.com/products/microvitamin-plus πŸ’ŠMicroVitamin Standard Capsules: https://drstanfield.com/products/microvitamin 🩺 Get your personalized health roadmap (free): https://drstanfield.com/pages/roadmap Timestamps: 00:00 The Discovery of Nicotinamide Riboside 01:22 NR vs NMN Debate 02:24 The New NR vs NMN (Bergen) Study 03:15 The Contradictory NR vs NN Nature Metabolism Study 03:51 The Hidden Truth in the Bervin Data 06:37 The Evidence Against NR and NMN 09:38 Conclusion & Key Takeaways βœ”οΈ X: https://x.com/BradStanfieldMD βœ”οΈ Patreon: https://www.patreon.com/bradstanfieldmd Here are the links to the research papers referenced in the video: https://link.springer.com/article/10.1007/s11357-023-01011-0 β€” Astaxanthin/meclizine extend lifespan (ITP 2023) https://ax3.life/ β€” AX3 supplement marketing claim https://rejuvant.com/ β€” Rejuvant AKG supplement https://www.globenewswire.com/news-release/2023/03/28/2635803/0/en/67-Year-Old-Founder-of-Ponce-De-Leon-Health-Achieves-Longevity-Escape-Velocity-with-Rejuvant.html β€” "Longevity escape velocity" press release https://link.springer.com/article/10.1007/s11357-026-02201-2 β€” ITP 2026 results (astaxanthin, AKG, etc. all fail) https://www.nia.nih.gov/research/dab/interventions-testing-program-itp β€” ITP program page https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/about-itp β€” About the ITP https://www.science.org/doi/10.1126/science.aaf2693 β€” NR extends lifespan in mice (Zhang 2016) https://pmc.ncbi.nlm.nih.gov/articles/PMC8135004/ β€” NR fails in ITP https://pmc.ncbi.nlm.nih.gov/articles/PMC9494524/ β€” Rapamycin discovery history (Easter Island) https://www.nature.com/articles/nature08221 β€” Rapamycin extends lifespan (ITP 2009) https://www.science.org/doi/10.1126/science.326.5960.1600 β€” Science "Runners-Up" 2009 https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/supported-interventions β€” ITP supported interventions list https://pmc.ncbi.nlm.nih.gov/articles/PMC8508957/ β€” AKG extends lifespan (Buck Institute 2020) https://www.buckinstitute.org/news/a-metabolite-produced-by-the-body-increases-lifespan-and-dramatically-compresses-late-life-morbidity-in-mice/ β€” Lithgow "nightmare scenario" quote https://x.com/davidasinclair/status/1300868036023459841 β€” Sinclair AKG tweet https://www.aging-us.com/article/203736/text β€” Rejuvant 8-year biological age claim study https://www.mdpi.com/2673-8856/5/2/28 β€” Horvath clock comparison (TruAge error margin) https://www.nature.com/articles/nature05354 β€” Resveratrol in mice (Sinclair 2006) https://www.fiercebiotech.com/biotech/glaxosmithkline-gsk-to-acquire-sirtris-pharmaceuticals-a-world-leader-sirtuin-research-and β€” GSK acquires Sirtris for $720M https://pmc.ncbi.nlm.nih.gov/articles/PMC2832984 β€” Resveratrol not a direct SIRT1 activator https://www.fiercebiotech.com/biotech/safety-concerns-force-glaxo-to-suspend-enrollment-srt501-trial β€” SRT501 kidney damage trial halt https://www.bioworld.com/articles/438084 β€” GSK closes Sirtris https://www.levels.com/blog/matt-kaeberlein-longevity-science β€” Kaeberlein "most debunked" quote https://pmc.ncbi.nlm.nih.gov/articles/PMC8472736/ β€” Astaxanthin skin meta-analysis Thumbnail by James Kelly Video edited by Troy Young Script by John Milliken The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Top Comments (10)

@JP-AT 2026-04-03

67yo, very fit, I found absolutely no physical benefit from taking NMN and NR (for 1 year) apart from a blood test showing dramatically increased NAD+. (For whatever thats worth). I started taking 500mg niacin which also increased NAD+ but for $4/mo - again - for whatever thats worth.

172 60 replies
@DrBradStanfield 2026-04-03

All 11 studies referenced in the video are linked in the video's description 🩺 Get your personalized health roadmap from Dr Brad: https://drstanfield.com/pages/roadmap

19 13 replies
@VTVT1306 2026-04-04

Took both of it separately for months and noticed… zero.

15
@jeff3wcapital 2026-04-03

Great research Doc, as always. Love your honesty and transparency. We need more like you mate.

10
@robertjohnson5127 2026-04-03

Well done, Dr Happy I never invested in those expensive supplements

6
@derekb117 2026-06-18

Oh mate, you're getting so good. perfect pacing, good understanding, very palatable information, and you're only saying what's really necessary. Getting to the point quickly, but not too quick. Love your videos.

5
@DustinHallXVX 2026-04-09

You saved me so much money. Thank you.

5
@Zanthous_ 2026-04-04

Cool, happy to have closure on this finally.

2
@willbrink 2026-06-30

Since day one of the whole NR/NMN interest, I simply asked where the comparative studied against B3 were. Crickets was the response. So, this is my shocked face...

2
@Cyclone546 2026-06-18

You just saved me a lot of money. Thank you.

1

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