Breakthrough Cuts Heart Disease by 25%
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The Genetic Breakthrough Leading to Oral PCSK9 Inhibitors
Discover the decades-long genetic quest that identified PCSK9, unlocking a major biological switch for lowering dangerous LDL cholesterol. Learn how this knowledge led to injectable breakthroughs and, critically, the recent development of convenient oral treatments.
Short Summary
- Pinpoint the PCSK9 discovery that provided crystal-clear drug target validation for cholesterol reduction.
- Confirm that primary prevention trials successfully used PCSK9 inhibitors to prevent the first major cardiovascular events in high-risk patients.
- A new oral PCSK9 inhibitor now matches the LDL lowering efficacy of previous injectable therapies, promising wider accessibility.
This summary tracks the evolution from identifying the PCSK9 gene mutation in rare families to validating the treatment in large-scale prevention trials, culminating in more accessible delivery methods.
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Top Comments (10)
This is me, first heart attack age 35, second at age 38, another Angio at 42, Negative for the genetic markers & statin intolerant and then trials of evolocumab in 2016, still here 9 years after starting Repatha (evolocumab) and my LDL levels are awesome, it's been a real life saver and I'd never of been around long enough to see my daughter grow up. Thanks to everyone involved around the world.
You're setting a high bar for Primary care medicine. Rock on!
PCSK9 inhibitors are produced using genetically modified Chinese hamster ovary (CHO) cells through a process called recombinant DNA technology. The gene that codes for the specific human monoclonal antibody that can bind to PCSK9 is inserted into the DNA of Chinese hamster ovary cells in a laboratory setting. These modified CHO cells are then grown in large-scale cell cultures. The cells are essentially turned into tiny factories that follow the genetic instructions to produce the target antibody. The antibodies produced by the cells are secreted into the cell culture medium. This medium is collected, and the antibodies are purified to create the final pharmaceutical product, such as alirocumab (Praluent) and evolocumab (Repatha).
All 4 studies referenced in the video are linked in the video's description 💊Supplements that Dr Brad takes: https://drstanfield.com/pages/my-supplements 💊MicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin For extra insights + a free health checklist, sign up here 👉 https://drstanfield.com/pages/sign-up
You do a great job communicating the story of how these studies happen. Thanks for your hard work
Can’t wait for the costs for PCSK9 inhibitors go down the same as statins and Ezetimibe. Even more lives will be saved with cholesterol lowering pharmaceutical interventions. This was super informative!
Great summary, thanks!
sounds suspiciously like an infomercial
Great info. Thanks.
Excellent!
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Top Comments (10)
This is me, first heart attack age 35, second at age 38, another Angio at 42, Negative for the genetic markers & statin intolerant and then trials of evolocumab in 2016, still here 9 years after starting Repatha (evolocumab) and my LDL levels are awesome, it's been a real life saver and I'd never of been around long enough to see my daughter grow up. Thanks to everyone involved around the world.
You're setting a high bar for Primary care medicine. Rock on!
PCSK9 inhibitors are produced using genetically modified Chinese hamster ovary (CHO) cells through a process called recombinant DNA technology. The gene that codes for the specific human monoclonal antibody that can bind to PCSK9 is inserted into the DNA of Chinese hamster ovary cells in a laboratory setting. These modified CHO cells are then grown in large-scale cell cultures. The cells are essentially turned into tiny factories that follow the genetic instructions to produce the target antibody. The antibodies produced by the cells are secreted into the cell culture medium. This medium is collected, and the antibodies are purified to create the final pharmaceutical product, such as alirocumab (Praluent) and evolocumab (Repatha).
All 4 studies referenced in the video are linked in the video's description 💊Supplements that Dr Brad takes: https://drstanfield.com/pages/my-supplements 💊MicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin For extra insights + a free health checklist, sign up here 👉 https://drstanfield.com/pages/sign-up
You do a great job communicating the story of how these studies happen. Thanks for your hard work
Can’t wait for the costs for PCSK9 inhibitors go down the same as statins and Ezetimibe. Even more lives will be saved with cholesterol lowering pharmaceutical interventions. This was super informative!
Great summary, thanks!
sounds suspiciously like an infomercial
Great info. Thanks.
Excellent!