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This Stops Insulin Resistance in Its Tracks | Dr. Roshani Sanghani

2025-09-02 Education
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2.2k
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Jesse Chappus
Jesse Chappus
461.0k subscribers

The Mechanics of Insulin Resistance: Reversal Strategies from an Endocrinologist

Start reversing insulin resistance within one week by optimizing protein intake and making strategic cognitive shifts. Learn how chronic high insulin impacts every organ and discover the four lifestyle pillars necessary for true metabolic recovery.

Short Summary

  • Identify initial insulin resistance signs early, often before symptoms appear, especially if you are of South Asian descent.
  • Upgrading protein intake (1.2g/kg or 25g per meal) precedes carbohydrate reduction for sustainable changes.
  • Chronic elevated insulin drives fat accumulation in vital organs like the liver and pancreas, potentially leading to failure.
  • Stress, poor sleep quality, and muscle loss accelerate metabolic decline, requiring management across four core pillars.
  • Use Motivational Interviewing techniques to overcome self-sabotage and align behavior with health goals.

This episode with endocrinologist Dr. Roshani Sanghani details the progression from insulin resistance to Type 2 Diabetes, using vivid analogies to explain cellular storage mechanics. Discover actionable, science-backed strategies focusing on nutrition, sleep, stress, and exercise to reclaim metabolic flexibility and avoid disease complications spanning brain, eyes, and kidneys.

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Description

If you enjoy hearing all about insulin resistance with Dr. Roshani Sanghani, I recommend you check out my conversation with Dr. Robert Lustig, which you can find here 👉 https://youtu.be/i2Vuqeriwvs Dr. Roshani Sanghani is a board-certified endocrinologist and metabolic health practitioner. She's an expert in insulin resistance reversal and hormone optimization. Subscribe to The Jesse Chappus Show on YouTube: https://www.youtube.com/@JesseChappus (And be sure to hit the 🔔 to get notified when new videos are released!) In this episode, we discuss: 00:00 - Intro 01:07 - The first signs and symptoms of insulin resistance 11:40 - Fatty liver and fatty pancreas 25:30 - How Roshani became pre-diabetic 31:16 - Eat this way to reverse insulin resistance 44:46 - Is fasting right for you? 1:02:19 - The top 2 ways sleep impacts your metabolic health 1:08:44 - What is motivational interviewing? 1:24:22 - Exercises to fix insulin resistance Show notes: https://jessechappus.com/668 Listen & subscribe to The Jesse Chappus Show ✩ Apple Podcasts: https://podcasts.apple.com/podcast/id921854276 ✩ Spotify: https://open.spotify.com/show/5A1vpgPVZTSEs70d2KTpk1 Connect with The Jesse Chappus Show ✩ Website: https://jessechappus.com ✩ Instagram: https://www.instagram.com/jessechappusshow #drroshanisanghani #jessechappus #insulinresistance About the Podcast Jesse Chappus has in-depth conversations with health and wellness leaders from around the world. Topics include lifestyle, nutrition, fitness, self-help, sleep, meditation, spirituality and so much more. Tune in weekly to take your health to the next level!

Top Comments (10)

@JesseChappus 2025-09-02

Thanks for watching this episode with Dr. Roshani Sanghani! If you're finding it valuable, please let me know by hitting the LIKE button on the video. I really appreciate the support 🙏 -Jesse 💙

95 5 replies
@MrCocoandchanel 2025-09-02

Plan to listen to this interview on my walk in the mountains of NC this afternoon. 75 yr old female. I love Jesse's in depth interviews. Especially on my hikes. ♥️ Always fabulous information 😊

65 5 replies
@jarhead4657 2025-09-05

3 weeks of no sugar and low carb and I feel so much better.

53 2 replies
@katiefaith5381 2025-09-02

Drop the carbs up the protein resistance training, build muscle. Stop watching the scale for a while🎉

47 5 replies
@franktremmellNBN 2025-09-02

Excellent interview. This video will be shared to many of my friends. This is the first time I have listened to @Dr Roshani Sanghani. She is very eloquent, clear speaking and to the point. She describes insulin resistance and metabolic health in a clear and understandable manner. I am animal based, but the doctor gives the most balanced description of plant based/vegetarian ketogenic diet I have heard. Thank you.

37 2 replies
@sadashak4 2025-09-04

As someone who trained in utilizing motivational interviewing, I want to applaud her, taking that knowledge and skill set toward behavior change around food for people. That’s super awesome!

30
@doorpakor5813 2025-12-12

I am indian. So genetically predisposition. I was able to bring my A1C down in 2 months by avoiding eating out and lowering carbs.😊

24
@2bNot 2025-09-03

In my mind, i trace the problem back to so many doctors, failing to solve anything much at all, but not one of them ever testing the insulin levels or even mentioning it. Perhaps they just think "well you look healthy" ? Even now, if they do the lazy BMI thing, which my doctor takes no account of how many heavy layers i am wearing, and then asks me how tall i am, often suggesting i am taller, but not once ever measuring, to make sure... I can do a better job myself at home. I can also check my own blood pressure or heart rate. I leave there with pills i don't need, one that i do, and really why do i need to go there at all ? They are always too busy, and running late, so if i die, its a relief for them.

16
@tienlu7599 2025-09-02

Thanks Jessie. May the grace and mercy of the Lord Jesus Christ be with you always 🙏❤️

12
@mrmrtsuresh 2025-11-06

One among lady Drs in India realize and promote this diet to solve the metabolic issues.

11

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