Navigate Select ESC Close

This Ends Insulin Resistance (in days NOT years)

2025-10-16 People & Blogs
250.8k
12.2k
651
Thomas DeLauer
Thomas DeLauer
4.0m subscribers

Decoding Insulin Resistance: Mechanisms, Risks, and Reversal Toolkits

Learn why insulin resistance is the primary driver of chronic disease, affecting lean individuals too, and discover six actionable steps utilizing nutrient timing, movement, and cellular mechanics to reclaim cellular energy efficiency today.

Short Summary

  • Insulin resistance is a microscopic cellular communication breakdown where fat-derived sludge (DAG) jams glucose uptake, often preceding Type 2 Diabetes.
  • Up to 44.8% of young adults (18–44) have IR, often without obesity, showing high cardiovascular risk independent of LDL.
  • Reversing IR requires manual overrides (post-meal walks), slowing fuel delivery (fiber), clearing cellular sludge (TMG), and strategic fasting (Master Reset).
  • This guide explains the physical origins of fatigue and sugar cravings, positioning IR as a widespread, yet reversible, metabolic dysfunction.
  • Strategies focus on improving Glut4 signaling by activating insulin-independent pathways like EMPK and enhancing cellular cleanup processes like autophagy.

Unlock all features

FREE: Get instant access to 10 AI summaries, chats, or transcripts per day.

Description

Join Thrive Market Today to get 30% Off Your First Order AND a Free Gift Worth up to $60! http://ThriveMarket.com/Thomas #thrivemarketpartner This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. Click HERE to Subscribe: https://www.youtube.com/c/ThomasDeLauerOfficial?sub_confirmation=1 Please check out the new Shorts channel, DeLauer Clips and Workouts, here: https://www.youtube.com/channel/UCQPQImPsw74KhO0Zy2-leyA/videos Please Subscribe to my Email Newsletter Here: https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer References https://academic.oup.com/jcem/article/107/1/e25/6362635 https://diabetesjournals.org/care/article/29/11/2427/24553/Prevalence-and-Determinants-of-Insulin-Resistance https://pubmed.ncbi.nlm.nih.gov/31336505/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803387/ https://pubmed.ncbi.nlm.nih.gov/30067154/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774584/ Timestamps ⏱ 0:00 - Intro 1:49 - Insulin Resistance vs Diabetes 3:16 - Who Really Has Insulin Resistance? 5:39 - Insulin Resistance Mechanisms 7:19 - IR Toolkit: Actionable Solutions 7:48 - IR Toolkit: Step #1 - 10-15 Min Walk After a Meal 8:03 - IR Toolkit: Step #2 - Strategic Use of Carbs 9:37 - IR Toolkit: Step #3 - Slow Down the Fuel Pump 10:27 - 30% Off Your First Order AND a Free Gift Worth up to $60 11:39 - IR Toolkit: Step #4 - Clear Out the Sludge with this Supplement 12:46 - IR Toolkit: Step #5 - Utilize this Spice to Enhance Insulin Sensitivity 13:42 - IR Toolkit: Step #6 - Hit the Master Reset 16:21 - IR Toolkit Recap

Top Comments (10)

@ava.artemis 2025-10-16

I’m still highly insulin resistant, even after 20 years of paleo-keto-carnivore, because of severe chronic insomnia, stress, illness, pain and injuries. I just learned recently that poor sleep, illness, inflammation, injuries and stress can all cause insulin resistance and even diabetes. If they’re isolated incidents, then insulin resistance resolves quickly. But if they’re chronic, and additive, then insulin resistance becomes chronic. I’m finally starting to sleep better, after 35 years of insomnia, and finally getting stress to a manageable level. I hope there’s still hope for me.

882 211 replies
@amphortas1 2025-10-17

1. 16 hours fasting 2. 10 - 15 minutes walk after a meal 3. Psyllium husk, Chia seeds (water, yogurt) with a meal 4. Ceylon Cinnamon 5. Carnosine 6. TMG trimethylglycine

780 38 replies
@Volker-k7u 2025-10-18

It’s insane how underrated book called Secret Testosterone Nexus of Evolution still is. Anyone serious about peak testosterone should’ve read this already.

458 3 replies
@Goravezz 2025-10-16

Carnosine TMG Cinnamon Fasting

357 22 replies
@Karmonulot 2025-10-16

hi so mid June this year my blood came back 50, diabetic. I followed you and a couple others, and 2.5 months later went back to the doctor with a 36, non diabetic. I also lost 20kg in that time. I can't begin to tell you how the information you provide can be used to turn your health around. my doc shook my hand and said he'd never seen any patient of his reverse diabetes in the time I did. seriously you changed my life.

354 20 replies
@meropale 2025-10-18

Stress and sleep are much harder to maintain than diet and exercise. At least for me.

316 13 replies
@MarcosCapixaba 2025-10-17

### Summary: Understanding and Reversing Insulin Resistance #### **I. Introduction & Core Problem** * **The Goal:** To reverse insulin resistance quickly, in days, not years, using modern science. * **Personal Experience:** The speaker experienced classic symptoms: post-carb exhaustion, spongy midsection fat, and uncontrollable carb cravings. * **The Paradigm Shift:** It's not a lack of willpower but a **"microscopic communication breakdown"** inside cells. Insulin's signal gets jammed, leaving the body starved for energy despite ample fuel. * **Definition:** Insulin resistance is the root cause, not just a precursor to diabetes, but the **greatest driver of chronic disease**. * **Video Purpose:** To explain the difference between IR and diabetes, reveal who is at risk, explain the cellular mechanism, and provide an actionable toolkit. #### **II. Insulin Resistance vs. Diabetes** * **Analogy:** Insulin resistance is a **"long smoldering fire"**; Type 2 diabetes is when the **"house is burning down."** * **The Mechanism:** * Eating raises blood sugar, triggering insulin release (the "key"). * Insulin is supposed to unlock muscle cells (via GLUT4 "doors") to let sugar in for energy. * In IR, the cells become resistant—the "lock gets rusty." * The pancreas compensates by producing **more insulin**, which can keep blood sugar levels normal on standard tests for years, hiding the underlying problem. * **The Issue:** Doctors often only check fasting glucose, which appears normal due to high insulin, missing the critical IR phase where symptoms (fatigue, brain fog, weight gain) are already present. #### **III. Who Really Has Insulin Resistance?** * **Prevalence:** A study found **44.8% of young adults (18-44)** have insulin resistance. * **The Shocker:** Half of those with IR are **not obese**. Millions of lean people have it without knowing—a phenomenon called **"thin outside, fat inside."** * **Risks:** Insulin resistance is a **more powerful predictor of cardiovascular disease than LDL cholesterol.** * **The Damage - Glycation:** Excess sugar in the bloodstream causes "glycation" (like internal caramelization), which damages proteins, blood vessels, and collagen, accelerating aging and organ damage. #### **IV. The Cellular Mechanism: What's Jamming the Signal?** * **The Cast:** * **Muscle Cell:** The garage. * **GLUT4 Transporter:** The garage door. * **Glucose:** The car that needs to get in. * **Insulin:** The remote control that opens the door. * **The Problem:** In IR, the remote's signal is jammed. **Inflammation** blocks it. * **The Culprit:** A fat-derived metabolite called **Diacylglycerol (DAG)**, which acts like a "thick, sticky sludge" that seeps into the garage door's receiver, jamming the signal. * **Root Cause:** DAG is created when overstuffed fat cells leak fatty acids into muscles and the liver, often due to **overnutrition** (too much fuel from any source). #### **V. The IR Toolkit: Actionable Solutions** A powerful, multi-step approach to unjam signals and reverse the process. * **Step #1: The Manual Override - 10-15 Min Walk After a Meal** * **Action:** Take a short walk after eating. * **Why:** Muscle contractions activate the **AMPK pathway**, which forces the GLUT4 doors open, bypassing the jammed insulin signal entirely. * **Step #2: Strategic Use of Carbs - Fuel Your Workouts** * **Action:** Consume a small amount of fast-digesting carbs **during resistance training**. * **Why:** Exercise opens the GLUT4 doors, allowing you to shuttle glucose directly into working muscles for immediate fuel without a large insulin spike. * **Step #3: Slow Down the Fuel Pump - Use Protein & Soluble Fiber** * **Action:** Use soluble fiber (e.g., acacia, psyllium, chia seeds) and protein with meals. * **Why:** This slows the absorption of carbs and fats, turning a "fire hose of fuel into a gentle stream." This prevents the overflow that creates DAG sludge. * **Step #4: Clear Out the Sludge - Supplement with TMG** * **Action:** Consider Trimethylglycine (TMG). * **Why:** TMG supports mitochondrial function and activates AMPK, helping the body burn excess fatty acids for fuel, preventing them from turning into DAG and helping clear existing sludge. * **Step #5: Enhance Insulin Sensitivity - Utilize Cinnamon** * **Action:** Add a small amount (e.g., 1/4 tsp) of Ceylon cinnamon to your diet. * **Why:** Compounds in cinnamon act as **insulin mimetics**, helping the insulin receptor itself become more sensitive to the signal, effectively "cleaning the rusty lock." * **Step #6: Hit the Master Reset - Implement Intermittent Fasting** * **Action:** Practice intermittent fasting (e.g., 16:8). * **Why:** Fasting dramatically lowers insulin, giving cells a break. It cranks up **AMPK and autophagy**, the body's cellular cleanup process that clears out DAG sludge. It flips genetic switches that improve metabolic efficiency. #### **VI. Additional Tool & Mindset Shift** * **Defense Against Glycation:** Supplement with **Carnosine** (3-6g), which acts as a "sacrificial shield" to intercept sticky sugar molecules and prevent tissue damage. * **The Interesting Twist:** Insulin resistance can be a survival tool. During fasting, the body makes muscles temporarily resistant to spare glucose for the brain. Constant overnutrition tricks the body into activating this same "ancient program" incorrectly. * **Final Message:** You are not broken. Your body is responding to the wrong signals from a modern environment of overnutrition. Using this toolkit sends the right signals to "open the doors and let the energy in."

186 7 replies
@kvpc11 2025-10-18

I had the pleasure of meeting Thomas on vacation in Switzerland and actually thank him in person. He has helped myself and no doubt countless others on improving our health and our lives. He was a gentleman, a dedicated family man and his physique shows that he practices what he preaches. Thank you for everything!

137
@ThomasDeLauerOfficial 2025-10-17

I put together a meal plan for insulin resistance using Whole Foods, here it is for free: http://www.thomasdelauer.com/eatrealfood - The best way to adhere to something is just have a plan. This is a thank you for joining my newsletter and subscribing

111 26 replies
@jillkirby7158 2025-10-29

2 years ago I asked my doc to check my insulin level. He didn't know what this was, so after I explained this to him, he checked it. My leve was 61mIU/L (normal 2-25 mIU/L). I asked him how to fix it. His reply, "I don't know. You're the one who asked me to check it." After a lot of research, I figured it out. My insulin is normal now. As a Nurse Practitioner, I check this on all my patients. This can stop type 2 diabetes 5 years before it shows on other blood tests. Advocate for yourself and have this checked!!

31 7 replies

Unlock the Data Inside
Turn Videos into Knowledge

  • Get FREE 10/day: transcripts, summaries, chats
  • Chat with videos, export text & PDF
  • $1 free API credit for RAG, chatbots & research

Free forever plan • All features unlocked

App screenshot