This Ends Insulin Resistance (in days NOT years)
Decoding Insulin Resistance: Mechanisms, Risks, and Reversal Toolkits
Learn why insulin resistance is the primary driver of chronic disease, affecting lean individuals too, and discover six actionable steps utilizing nutrient timing, movement, and cellular mechanics to reclaim cellular energy efficiency today.
Short Summary
- Insulin resistance is a microscopic cellular communication breakdown where fat-derived sludge (DAG) jams glucose uptake, often preceding Type 2 Diabetes.
- Up to 44.8% of young adults (18–44) have IR, often without obesity, showing high cardiovascular risk independent of LDL.
- Reversing IR requires manual overrides (post-meal walks), slowing fuel delivery (fiber), clearing cellular sludge (TMG), and strategic fasting (Master Reset).
- This guide explains the physical origins of fatigue and sugar cravings, positioning IR as a widespread, yet reversible, metabolic dysfunction.
- Strategies focus on improving Glut4 signaling by activating insulin-independent pathways like EMPK and enhancing cellular cleanup processes like autophagy.
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Top Comments (10)
I’m still highly insulin resistant, even after 20 years of paleo-keto-carnivore, because of severe chronic insomnia, stress, illness, pain and injuries. I just learned recently that poor sleep, illness, inflammation, injuries and stress can all cause insulin resistance and even diabetes. If they’re isolated incidents, then insulin resistance resolves quickly. But if they’re chronic, and additive, then insulin resistance becomes chronic. I’m finally starting to sleep better, after 35 years of insomnia, and finally getting stress to a manageable level. I hope there’s still hope for me.
1. 16 hours fasting 2. 10 - 15 minutes walk after a meal 3. Psyllium husk, Chia seeds (water, yogurt) with a meal 4. Ceylon Cinnamon 5. Carnosine 6. TMG trimethylglycine
It’s insane how underrated book called Secret Testosterone Nexus of Evolution still is. Anyone serious about peak testosterone should’ve read this already.
Carnosine TMG Cinnamon Fasting
hi so mid June this year my blood came back 50, diabetic. I followed you and a couple others, and 2.5 months later went back to the doctor with a 36, non diabetic. I also lost 20kg in that time. I can't begin to tell you how the information you provide can be used to turn your health around. my doc shook my hand and said he'd never seen any patient of his reverse diabetes in the time I did. seriously you changed my life.
Stress and sleep are much harder to maintain than diet and exercise. At least for me.
### Summary: Understanding and Reversing Insulin Resistance #### **I. Introduction & Core Problem** * **The Goal:** To reverse insulin resistance quickly, in days, not years, using modern science. * **Personal Experience:** The speaker experienced classic symptoms: post-carb exhaustion, spongy midsection fat, and uncontrollable carb cravings. * **The Paradigm Shift:** It's not a lack of willpower but a **"microscopic communication breakdown"** inside cells. Insulin's signal gets jammed, leaving the body starved for energy despite ample fuel. * **Definition:** Insulin resistance is the root cause, not just a precursor to diabetes, but the **greatest driver of chronic disease**. * **Video Purpose:** To explain the difference between IR and diabetes, reveal who is at risk, explain the cellular mechanism, and provide an actionable toolkit. #### **II. Insulin Resistance vs. Diabetes** * **Analogy:** Insulin resistance is a **"long smoldering fire"**; Type 2 diabetes is when the **"house is burning down."** * **The Mechanism:** * Eating raises blood sugar, triggering insulin release (the "key"). * Insulin is supposed to unlock muscle cells (via GLUT4 "doors") to let sugar in for energy. * In IR, the cells become resistant—the "lock gets rusty." * The pancreas compensates by producing **more insulin**, which can keep blood sugar levels normal on standard tests for years, hiding the underlying problem. * **The Issue:** Doctors often only check fasting glucose, which appears normal due to high insulin, missing the critical IR phase where symptoms (fatigue, brain fog, weight gain) are already present. #### **III. Who Really Has Insulin Resistance?** * **Prevalence:** A study found **44.8% of young adults (18-44)** have insulin resistance. * **The Shocker:** Half of those with IR are **not obese**. Millions of lean people have it without knowing—a phenomenon called **"thin outside, fat inside."** * **Risks:** Insulin resistance is a **more powerful predictor of cardiovascular disease than LDL cholesterol.** * **The Damage - Glycation:** Excess sugar in the bloodstream causes "glycation" (like internal caramelization), which damages proteins, blood vessels, and collagen, accelerating aging and organ damage. #### **IV. The Cellular Mechanism: What's Jamming the Signal?** * **The Cast:** * **Muscle Cell:** The garage. * **GLUT4 Transporter:** The garage door. * **Glucose:** The car that needs to get in. * **Insulin:** The remote control that opens the door. * **The Problem:** In IR, the remote's signal is jammed. **Inflammation** blocks it. * **The Culprit:** A fat-derived metabolite called **Diacylglycerol (DAG)**, which acts like a "thick, sticky sludge" that seeps into the garage door's receiver, jamming the signal. * **Root Cause:** DAG is created when overstuffed fat cells leak fatty acids into muscles and the liver, often due to **overnutrition** (too much fuel from any source). #### **V. The IR Toolkit: Actionable Solutions** A powerful, multi-step approach to unjam signals and reverse the process. * **Step #1: The Manual Override - 10-15 Min Walk After a Meal** * **Action:** Take a short walk after eating. * **Why:** Muscle contractions activate the **AMPK pathway**, which forces the GLUT4 doors open, bypassing the jammed insulin signal entirely. * **Step #2: Strategic Use of Carbs - Fuel Your Workouts** * **Action:** Consume a small amount of fast-digesting carbs **during resistance training**. * **Why:** Exercise opens the GLUT4 doors, allowing you to shuttle glucose directly into working muscles for immediate fuel without a large insulin spike. * **Step #3: Slow Down the Fuel Pump - Use Protein & Soluble Fiber** * **Action:** Use soluble fiber (e.g., acacia, psyllium, chia seeds) and protein with meals. * **Why:** This slows the absorption of carbs and fats, turning a "fire hose of fuel into a gentle stream." This prevents the overflow that creates DAG sludge. * **Step #4: Clear Out the Sludge - Supplement with TMG** * **Action:** Consider Trimethylglycine (TMG). * **Why:** TMG supports mitochondrial function and activates AMPK, helping the body burn excess fatty acids for fuel, preventing them from turning into DAG and helping clear existing sludge. * **Step #5: Enhance Insulin Sensitivity - Utilize Cinnamon** * **Action:** Add a small amount (e.g., 1/4 tsp) of Ceylon cinnamon to your diet. * **Why:** Compounds in cinnamon act as **insulin mimetics**, helping the insulin receptor itself become more sensitive to the signal, effectively "cleaning the rusty lock." * **Step #6: Hit the Master Reset - Implement Intermittent Fasting** * **Action:** Practice intermittent fasting (e.g., 16:8). * **Why:** Fasting dramatically lowers insulin, giving cells a break. It cranks up **AMPK and autophagy**, the body's cellular cleanup process that clears out DAG sludge. It flips genetic switches that improve metabolic efficiency. #### **VI. Additional Tool & Mindset Shift** * **Defense Against Glycation:** Supplement with **Carnosine** (3-6g), which acts as a "sacrificial shield" to intercept sticky sugar molecules and prevent tissue damage. * **The Interesting Twist:** Insulin resistance can be a survival tool. During fasting, the body makes muscles temporarily resistant to spare glucose for the brain. Constant overnutrition tricks the body into activating this same "ancient program" incorrectly. * **Final Message:** You are not broken. Your body is responding to the wrong signals from a modern environment of overnutrition. Using this toolkit sends the right signals to "open the doors and let the energy in."
I had the pleasure of meeting Thomas on vacation in Switzerland and actually thank him in person. He has helped myself and no doubt countless others on improving our health and our lives. He was a gentleman, a dedicated family man and his physique shows that he practices what he preaches. Thank you for everything!
I put together a meal plan for insulin resistance using Whole Foods, here it is for free: http://www.thomasdelauer.com/eatrealfood - The best way to adhere to something is just have a plan. This is a thank you for joining my newsletter and subscribing
2 years ago I asked my doc to check my insulin level. He didn't know what this was, so after I explained this to him, he checked it. My leve was 61mIU/L (normal 2-25 mIU/L). I asked him how to fix it. His reply, "I don't know. You're the one who asked me to check it." After a lot of research, I figured it out. My insulin is normal now. As a Nurse Practitioner, I check this on all my patients. This can stop type 2 diabetes 5 years before it shows on other blood tests. Advocate for yourself and have this checked!!
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Top Comments (10)
I’m still highly insulin resistant, even after 20 years of paleo-keto-carnivore, because of severe chronic insomnia, stress, illness, pain and injuries. I just learned recently that poor sleep, illness, inflammation, injuries and stress can all cause insulin resistance and even diabetes. If they’re isolated incidents, then insulin resistance resolves quickly. But if they’re chronic, and additive, then insulin resistance becomes chronic. I’m finally starting to sleep better, after 35 years of insomnia, and finally getting stress to a manageable level. I hope there’s still hope for me.
1. 16 hours fasting 2. 10 - 15 minutes walk after a meal 3. Psyllium husk, Chia seeds (water, yogurt) with a meal 4. Ceylon Cinnamon 5. Carnosine 6. TMG trimethylglycine
It’s insane how underrated book called Secret Testosterone Nexus of Evolution still is. Anyone serious about peak testosterone should’ve read this already.
Carnosine TMG Cinnamon Fasting
hi so mid June this year my blood came back 50, diabetic. I followed you and a couple others, and 2.5 months later went back to the doctor with a 36, non diabetic. I also lost 20kg in that time. I can't begin to tell you how the information you provide can be used to turn your health around. my doc shook my hand and said he'd never seen any patient of his reverse diabetes in the time I did. seriously you changed my life.
Stress and sleep are much harder to maintain than diet and exercise. At least for me.
### Summary: Understanding and Reversing Insulin Resistance #### **I. Introduction & Core Problem** * **The Goal:** To reverse insulin resistance quickly, in days, not years, using modern science. * **Personal Experience:** The speaker experienced classic symptoms: post-carb exhaustion, spongy midsection fat, and uncontrollable carb cravings. * **The Paradigm Shift:** It's not a lack of willpower but a **"microscopic communication breakdown"** inside cells. Insulin's signal gets jammed, leaving the body starved for energy despite ample fuel. * **Definition:** Insulin resistance is the root cause, not just a precursor to diabetes, but the **greatest driver of chronic disease**. * **Video Purpose:** To explain the difference between IR and diabetes, reveal who is at risk, explain the cellular mechanism, and provide an actionable toolkit. #### **II. Insulin Resistance vs. Diabetes** * **Analogy:** Insulin resistance is a **"long smoldering fire"**; Type 2 diabetes is when the **"house is burning down."** * **The Mechanism:** * Eating raises blood sugar, triggering insulin release (the "key"). * Insulin is supposed to unlock muscle cells (via GLUT4 "doors") to let sugar in for energy. * In IR, the cells become resistant—the "lock gets rusty." * The pancreas compensates by producing **more insulin**, which can keep blood sugar levels normal on standard tests for years, hiding the underlying problem. * **The Issue:** Doctors often only check fasting glucose, which appears normal due to high insulin, missing the critical IR phase where symptoms (fatigue, brain fog, weight gain) are already present. #### **III. Who Really Has Insulin Resistance?** * **Prevalence:** A study found **44.8% of young adults (18-44)** have insulin resistance. * **The Shocker:** Half of those with IR are **not obese**. Millions of lean people have it without knowing—a phenomenon called **"thin outside, fat inside."** * **Risks:** Insulin resistance is a **more powerful predictor of cardiovascular disease than LDL cholesterol.** * **The Damage - Glycation:** Excess sugar in the bloodstream causes "glycation" (like internal caramelization), which damages proteins, blood vessels, and collagen, accelerating aging and organ damage. #### **IV. The Cellular Mechanism: What's Jamming the Signal?** * **The Cast:** * **Muscle Cell:** The garage. * **GLUT4 Transporter:** The garage door. * **Glucose:** The car that needs to get in. * **Insulin:** The remote control that opens the door. * **The Problem:** In IR, the remote's signal is jammed. **Inflammation** blocks it. * **The Culprit:** A fat-derived metabolite called **Diacylglycerol (DAG)**, which acts like a "thick, sticky sludge" that seeps into the garage door's receiver, jamming the signal. * **Root Cause:** DAG is created when overstuffed fat cells leak fatty acids into muscles and the liver, often due to **overnutrition** (too much fuel from any source). #### **V. The IR Toolkit: Actionable Solutions** A powerful, multi-step approach to unjam signals and reverse the process. * **Step #1: The Manual Override - 10-15 Min Walk After a Meal** * **Action:** Take a short walk after eating. * **Why:** Muscle contractions activate the **AMPK pathway**, which forces the GLUT4 doors open, bypassing the jammed insulin signal entirely. * **Step #2: Strategic Use of Carbs - Fuel Your Workouts** * **Action:** Consume a small amount of fast-digesting carbs **during resistance training**. * **Why:** Exercise opens the GLUT4 doors, allowing you to shuttle glucose directly into working muscles for immediate fuel without a large insulin spike. * **Step #3: Slow Down the Fuel Pump - Use Protein & Soluble Fiber** * **Action:** Use soluble fiber (e.g., acacia, psyllium, chia seeds) and protein with meals. * **Why:** This slows the absorption of carbs and fats, turning a "fire hose of fuel into a gentle stream." This prevents the overflow that creates DAG sludge. * **Step #4: Clear Out the Sludge - Supplement with TMG** * **Action:** Consider Trimethylglycine (TMG). * **Why:** TMG supports mitochondrial function and activates AMPK, helping the body burn excess fatty acids for fuel, preventing them from turning into DAG and helping clear existing sludge. * **Step #5: Enhance Insulin Sensitivity - Utilize Cinnamon** * **Action:** Add a small amount (e.g., 1/4 tsp) of Ceylon cinnamon to your diet. * **Why:** Compounds in cinnamon act as **insulin mimetics**, helping the insulin receptor itself become more sensitive to the signal, effectively "cleaning the rusty lock." * **Step #6: Hit the Master Reset - Implement Intermittent Fasting** * **Action:** Practice intermittent fasting (e.g., 16:8). * **Why:** Fasting dramatically lowers insulin, giving cells a break. It cranks up **AMPK and autophagy**, the body's cellular cleanup process that clears out DAG sludge. It flips genetic switches that improve metabolic efficiency. #### **VI. Additional Tool & Mindset Shift** * **Defense Against Glycation:** Supplement with **Carnosine** (3-6g), which acts as a "sacrificial shield" to intercept sticky sugar molecules and prevent tissue damage. * **The Interesting Twist:** Insulin resistance can be a survival tool. During fasting, the body makes muscles temporarily resistant to spare glucose for the brain. Constant overnutrition tricks the body into activating this same "ancient program" incorrectly. * **Final Message:** You are not broken. Your body is responding to the wrong signals from a modern environment of overnutrition. Using this toolkit sends the right signals to "open the doors and let the energy in."
I had the pleasure of meeting Thomas on vacation in Switzerland and actually thank him in person. He has helped myself and no doubt countless others on improving our health and our lives. He was a gentleman, a dedicated family man and his physique shows that he practices what he preaches. Thank you for everything!
I put together a meal plan for insulin resistance using Whole Foods, here it is for free: http://www.thomasdelauer.com/eatrealfood - The best way to adhere to something is just have a plan. This is a thank you for joining my newsletter and subscribing
2 years ago I asked my doc to check my insulin level. He didn't know what this was, so after I explained this to him, he checked it. My leve was 61mIU/L (normal 2-25 mIU/L). I asked him how to fix it. His reply, "I don't know. You're the one who asked me to check it." After a lot of research, I figured it out. My insulin is normal now. As a Nurse Practitioner, I check this on all my patients. This can stop type 2 diabetes 5 years before it shows on other blood tests. Advocate for yourself and have this checked!!