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Improve Energy & Longevity by Optimizing Mitochondria | Dr. Martin Picard

2025-12-15 Science & Technology
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Andrew Huberman
Andrew Huberman
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Description

Dr. Martin Picard, PhD, is a professor of behavioral medicine at Columbia University and an expert on how our behaviors and psychology shape cellular energy production and rates of aging. He explains that your mitochondria don’t just “make energy”; they translate what you do—your mindset and your relationships—into the energy you experience as vitality or lack thereof. He explains how exercise, nutrition, sleep, meditation, and even certain thought patterns and our sense of purpose can charge our cells like batteries. He also shares findings that hair greying is the result of cellular stress and is reversible. This episode links physical and mental ‘energy’ with cellular energy and provides science-supported tools to improve your physical and mental health. Show notes: https://go.hubermanlab.com/dHanxYL *Thank you to our sponsors* AG1: https://drinkag1.com/huberman Helix: https://helixsleep.com/huberman Lingo: https://hellolingo.com/huberman Function: https://functionhealth.com/huberman Waking Up: https://wakingup.com/huberman *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Dr. Martin Picard* Personal website: https://martinpicard.energy Lab website: https://www.picardlab.org Academic profile: https://www.neurology.columbia.edu/profile/martin-picard-phd Publications: https://www.picardlab.org/all-publications.html TEDx talk: https://www.youtube.com/watch?v=idJo0hpLhyI Resources: https://www.picardlab.org/resources.html Scientific American: https://www.scientificamerican.com/author/martin-picard X: https://x.com/MitoPsychoBio LinkedIn: https://www.linkedin.com/in/mitopsychobio *Timestamps* 00:00:00 Martin Picard 00:03:50 What is Energy?, Energy Flow & Transformation 00:07:53 Energy, Vitality, Emotions, Sensory Perception 00:14:18 Sponsors: Helix Sleep & Lingo 00:17:19 “Mito-Centric” View of World, Mitochondrial Energy & Information Patterns 00:25:26 Organelles, Mitochondria & Energy Transformation; Maternal Genes 00:31:12 Mitotypes & Differentiation, Mitochondria as “Social Organisms” 00:36:52 Food & Dysfunctional Energy Transformation 00:40:02 Lifestyle Choices & Interests, Physiological Growth 00:46:39 Pregnancy, Amenorrhea; Illness & Tiredness 00:51:07 Sponsor: AG1 00:52:29 Energy Transformation & Distribution; Body’s Wisdom, Feeling Sick 00:56:27 Tool: Feel Your Energy; Breath & Energy 01:02:31 Flow of Energy; Trade-Offs, Life Purpose & Enjoyment 01:10:15 Biology, Meaningful Experiences & Energy Flow 01:16:27 Sponsor: Function 00:18:15 Inflammation, Energetic Flow 01:20:43 Child Prodigies, Species Lifespan & Mitochondrial Metabolism; Aging 01:28:56 Lifestyle & Aging: Exercise, Fasting; Inflammation, Sleep, Stimulants 01:37:06 Energetic Stress Signals, GDF-15, Cancer, Heart Failure 01:42:18 Genes, Lifestyle & Aging 01:47:54 Gray Hair Reversal, Stress; Inflammation & Aging 01:57:37 Energy Recovery, Sleep & Mitochondrial Function, Stress, Meditation 02:05:16 Tools: Yoga Nidra, NSDR; Pre-Sleep Relaxation, Energy & Restorative Sleep 02:10:58 Diet Individualization, Clinical Trials; Mitochondria & Nutrition, Keto 02:20:14 Alcohol; Energy Budget; Stress 02:25:02 Exercise, Increase Mitochondria, Overtraining; Resistance & Growth 02:33:06 Sponsor: Waking Up 02:34:41 Supplements & Mitochondria Health, Deficiencies, SS31, Methylene Blue 02:41:31 Energy Flow; Experiences, Balance 02:49:13 Transform Through Resistance, Energetic Awareness, Connection 02:56:05 Food Over-consumption Mitochondria Disruption; Tissues & Mitochondria 03:01:02 Mitochondrial Health Test; Tool: Ways to Increase Energy; Meditation 03:06:10 Peptides; Fertility Supplements, Urolithin A; Electromagnetic Fields 03:12:16 Acknowledgements 03:14:15 Zero-Cost Support, YouTube, Spotify; Apple Follow, Reviews; Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #HubermanLab #Science #Longevity Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Top Comments (10)

@deepost2604 2025-12-15

A glass shard severed a single nerve in my hand. Within weeks, I was amazed at the loss of muscle and grip strength. Surgery reconnected the nerve 2 months post injury. Then it took about 6 months to regain strength in my hand. It was a tedious process of teaching fingers to move again. He spoke of this connection as an aside, but for me, it was a life lesson.

156 14 replies
@hubermanlab 2025-12-15

Thank you for watching. Please click the subscribe tab and then the "bell" icon to subscribe to our channel here on YouTube and get notified when new content is posted... And thank you for your interest in science! -- Andrew

136 12 replies
@jasongravely7217 2025-12-17

I absolutely love when Dr Huberman has a guest like this and they get talking fast and in a flow state. Their depth and width of knowledge, passion and ideas combined with comfort with each other to create and share is so inspiring to see. We are lucky to be exposed to such bright humans in this state.

119
@abbybenson189 2025-12-18

Dr. Huberman, would you please consider doing an episode on chronic inflammatory conditions and science-based methods that can improve the quality of life for people who suffer from them? I suffer from Long Covid (for all practice purposes, CFS) and a number of other related conditions, and I know many others who suffer from similar conditions as well. Your podcast is down-to-earth and incredibly helpful, and I would deeply appreciate an episode specifically addressing this issue.

113 14 replies
@madameaeriel 2025-12-15

28:21 I pressed pause and rushed upstairs to thank my Mom for her mitochondria. She wasn’t impressed. And then again for the energy and longevity. She looked tired.

63 2 replies
@hillishudson32 2025-12-17

I'm infected by Dr. Picard's energy about energy. This is one of the most passionately engaging individuals I've ever listened to. I agree with Dr. Hubie, bridging the gap between woo and science has never felt so good and real.

57
@blackstripened 2025-12-16

Thank you Dr. Picard for showing up more on social media, your ability to teach us about these complicated topics is admired and appreciated.

34
@bikiv836 2025-12-30

This hair conversation is SOO AMAZING to me!! I’m a hairstylist for 25 years and science nerd. So I love this podcast…. The biggest questions I always get are about graying of the hair. But I love the part where they talk about collecting hair and going back into the persons life to find the stress. I have had a client who has Virgin hair. She has a health condition and had been in the hospital, had a procedure. The next time she came for a haircut, her hair had a kink in her naturally straight hair all the way around, and the color above the kink was a different color and texture than below the kink. I have been so intrigued by this. I was able to trace back her body trauma and it was spot on to where this kink was located. I really need to become a trichologist LOL. Thanks for this AWESOME podcast guys!!!❤

23
@Debra-r1p 2025-12-20

I was a nurse for 28 years a very burned out and stressed. I had a fatty liver and was very tired all the time and changed my diet. I’ve always been a positive person and listen to music for enjoyment. I have been told I have good energy and I hope you have any hair, but I’ve had my health issues changing my diet and removing myself from that special career has helped.

11
@angelatruluck6635 2026-02-28

I learned of yoga nidra from you almost a year ago. I now use it with my 4 yr old grand daughter. We lay down together for 15 minutes each night she is with me. The night time routine is so calm now compared to before. She reminds me “Gigi it’s yoga nidra time”. I am forever grateful.

5

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