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The Low-Dose Peptide I Take

2026-05-28 People & Blogs
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Dr Brad Stanfield
Dr Brad Stanfield
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🩺 Get your personalized health plan: https://drstanfield.com 💊 Supplements I Take: https://drstanfield.com/pages/my-supplements 💊MicroVitamin+ (Pro) Powder: https://drstanfield.com/products/microvitamin-plus 💊MicroVitamin Standard Capsules: https://drstanfield.com/products/microvitamin Timestamps: 00:00 Discovery of GLP-1 and Weight Loss Effects 01:33 Cardiovascular and Kidney Benefits of GLP-1 02:45 GLP-1 Medications and Cancer Progression 02:51 GLP-1 Medications and Joint Health 06:39 Benefits of GLP-1 and GIP Combination 08:57 Why Tirzepatide Over Retatrutide 09:52 My Personal Experience with Tirzepatide 10:23 Safety Concerns ✔️ X: https://x.com/BradStanfieldMD ✔️ Patreon: https://www.patreon.com/bradstanfieldmd Here are the links to the research papers referenced in the video: SELECT (Lincoff 2023) — https://www.nejm.org/doi/full/10.1056/NEJMoa2307563 FLOW (Perkovic 2024) — https://www.nejm.org/doi/10.1056/NEJMoa2403347 SURPASS-CVOT primary (Nicholls 2025) — https://www.nejm.org/doi/abs/10.1056/NEJMoa2505928 Exenatide history (Wikipedia) — https://en.wikipedia.org/wiki/Exenatide SCALE (Pi-Sunyer 2015) — https://www.nejm.org/doi/full/10.1056/NEJMoa1411892 STEP 1 (Wilding 2021) — https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 ASCO 2026 — GLP-1 + cancer progression — https://www.oncology-central.com/asco-2026-glp-1s-could-reduce-the-risk-of-some-obesity-related-cancers-progressing/ Cartilage regeneration review — https://pmc.ncbi.nlm.nih.gov/articles/PMC10071204/ Weight loss → knee-joint load (Messier 2005) — https://pubmed.ncbi.nlm.nih.gov/15986358/ STEP 9 (semaglutide + knee OA) — https://www.nejm.org/doi/abs/10.1056/NEJMoa2403664 Chen pair-fed mice / semaglutide + OA (Cell Metabolism 2026) — https://www.cell.com/cell-metabolism/fulltext/S1550-4131(26)00008-2 Di Chen quote — CGTN — https://news.cgtn.com/news/2026-02-12/-Weight-loss-wonder-drug-can-also-treats-osteoarthritis-study-finds-1KHcUiXzHsQ/p.html ESSENCE (Sanyal 2025, MASH) — https://www.nejm.org/doi/full/10.1056/NEJMoa2413258 Klausen Lancet (semaglutide + AUD, 2026) — https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00305-3 Retatrutide Phase 2 (Jastreboff 2023) — https://www.nejm.org/doi/full/10.1056/NEJMoa2301972 Tirzepatide vs Semaglutide HR — https://www.nejm.org/doi/full/10.1056/NEJMoa2107519 Pancreatitis meta-analysis — https://pubmed.ncbi.nlm.nih.gov/32720500/ Thyroid cancer + semaglutide review — https://pmc.ncbi.nlm.nih.gov/articles/PMC11050669/ FDA suicide signal evaluation (Jan 2024) — https://www.fda.gov/drugs/drug-safety-communications/update-fdas-ongoing-evaluation-reports-suicidal-thoughts-or-actions-patients-taking-certain-type GLP-1 calorie-intake reduction — https://pmc.ncbi.nlm.nih.gov/articles/PMC11340591/ Mozaffarian 2025 Joint Advisory (multivitamin-mineral recommendation) — https://pmc.ncbi.nlm.nih.gov/articles/PMC12304835/ MicroVitamin Labdoor review (99.7%) — https://labdoor.com/review/dr-brad-stanfield-microvitamin Thumbnail by James Kelly Video edited by Troy Young Script by John Milliken The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Top Comments (10)

@DrBradStanfield 2026-05-28

All 21 studies referenced in the video are linked in the video's description 🩺 Get your personalized health plan: https://drstanfield.com/pages/roadmap

17 3 replies
@michaelrichmond3137 2026-05-28

Low dose Tirzepetide for almost 2 yrs, 16kg sustained weight loss, very regular cardio and weight training, musclular lean build now, multi vitamin and creatine daily. It has made me feel 20yrs younger than my actual age AND my knees no longer creak, click or ache, everything you say is true.

86 11 replies
@HillLeeHill 2026-05-30

I've been taking it for my migraines. 2.5 for 6 months and now 5mg for about 6 months. I have no plans of going up and might try going down as long as it does not change the amount of relief I get from my chronic migraine and cluster headaches I've been getting. It' the only thing that has truly worked for me (70-90% reduction) out of the many many meds I have tried, and it has the least negative side effects.

13 5 replies
@inigomontoya68 2026-05-28

took mounjaro & BMI went from about 30 to 25 so stopped taking it - would like to micro dose as my weigth is creeping back up but cannot get a prescription any longer as Im not overweight enough anymore to qualify - they really need to change the rules to allow a maintenance dose for people who have lost weight

27 6 replies
@remixisthis 2026-05-28

I may hop on low dose Tirzepatide to convince my parents to get on it. It would help their help significantly

5
@Remikaflan 2026-05-29

Finally youre getting into peptides, waiting on your thoughts about ghk-cu topical or systemic

6 1 replies
@BuiltByGraft 2026-05-29

GLP1s have cured my lifelong ashtma. i take 1mg reta or tirezp weekly and it has stopped my use of clenil and seravent. its utterly insane. inhaled steroids interfere with adrenal hormones so this is a better medication for me. plus ive maintained my 40lb weight loss and feel amazing

4
@soterio5500 2026-05-28

Спасибо, док. Ваши видео очень информативны и интересны и без всякой хайповой кликбейтной шелухи, основанной на доклинических данных. Сам сижу уже год на тирзепатиде, до этого год на семаглутиде. И оба этих года делаю инъекции ингибиторов PCSK9. Плюс физ. нагрузки, средиземноморское питание, мультивитамины и небольшой стек добавок, имеющих более или менее хорошую доказательную базу. Метаболическое здоровье и показатели анализов сменились с ожирения и преддиабета на абсолютно идеальные анализы и самочувствие и приемлемый ИМТ.

8 1 replies
@devthefool 2026-05-29

Fire videos lately, man so glad you are here.

4
@yoyoschmo1 2026-05-29

I know Dr. Albert! Small world. I don’t think we can extrapolate that the post-hoc analysis on zepbound means that combo is better than GLP1. It may be molecule specific. GLP1 changes m1 to m2 macrophages and reduces inflammation, so is it the anti-inflammatory effect, the level of binding affinity, the level of receptor activation and corresponding transcription, etc. we don’t know. I do think it’s better tolerated and that is why as a physician I am taking zepbound low dose as well. And you don’t even have to look at real world data to feel reassured about pancreatitis. The pooled data from surmount 1 and 2 showed that the pancreatitis events were 0.15 patients per 100 years of exposure in placebo and 0.14 in zepbound.

3

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