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High Cortisol Wakes You Up at 3AM (Do This to Fall Back Asleep)

2025-09-29 People & Blogs
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Thomas DeLauer
Thomas DeLauer
4.0m subscribers

Leveraging Glycine for Superior Sleep Onset, Reduced Night Urination, and Emotional Resilience

Learn the precise 3-gram dosage and timing required for Glycine to cool your core body temperature, significantly decrease middle-of-the-night bathroom trips, and actively dampen stress responses before bed.

Short Summary

  • Glycine optimizes sleep by promoting core body cooling and accelerating the onset of restorative REM sleep cycles.
  • Research confirms a 3g daily intake significantly reduces nocturnal urination episodes (nocturia) via neurological suppression of the urge reflex.
  • Supplementing with Glycine can blunt the physiological impact of negative emotions, preventing stress from disrupting sleep quality. This overview explains the neurological mechanisms—specifically involving blood flow and the NMDA receptor—that validate Glycine’s use, and provides concrete dosing instructions to maximize these benefits.

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Description

15% off Verso's Evening Being: https://evening.ver.so/thomas This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. Click HERE to Subscribe: https://www.youtube.com/c/ThomasDeLauerOfficial?sub_confirmation=1 Please check out the new Shorts channel, DeLauer Clips and Workouts, here: https://www.youtube.com/channel/UCQPQImPsw74KhO0Zy2-leyA/videos Please Subscribe to my Email Newsletter Here: https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer References https://link.springer.com/article/10.1111/j.1479-8425.2007.00262.x https://pmc.ncbi.nlm.nih.gov/articles/PMC4397399/ https://www.degruyterbrill.com/document/doi/10.1515/jcim-2020-0282/html https://pmc.ncbi.nlm.nih.gov/articles/PMC5435551/ https://www.sciencedirect.com/science/article/abs/pii/S1087079223001466 https://pmc.ncbi.nlm.nih.gov/articles/PMC7181893/ https://www.sciencedirect.com/science/article/abs/pii/S0044848622000734 Timestamps ⏱ 0:00 - Intro 2:03 - How Does Glycine Influence Sleep? 3:49 - Reducing Nighttime Urination 6:19 - Glycine Dosing 6:38 - Verso's Evening Being 7:57 - Creatine 9:18 - How Glycine Helps Creatine for Sleep 9:55 - Emotional Blunting 12:45 - How to Use Glycine

Top Comments (10)

@nickskywalker2568 2025-09-30

Watching this in my bed at 3am

2.4k 187 replies
@philpsilos2167 2025-09-30

In case it helps someone - if you are regularly waking up at 3 with high arousal (cortisol), and if magnesium / glycine doesn’t help , get yourself checked for sleep apnea. Cortisol spikes when you’re fighting for breath, too.

602 40 replies
@HumilityisHumble 2025-10-02

We can’t sleep because the world is falling apart.

456 45 replies
@petriciahice4838 2025-10-06

Watching at 4:45 am after waking up at 3:30

447 10 replies
@tsveno72 2025-10-01

Tom, I have not had a night where I slept through the night in what seems like years until last night. I took 3 grams of glycine and woke up 30 minutes before my alarm. I usually wake up every 2-3 hours. Thanks for your recommendation. I don’t smoke or drink and now will add morning exercise to my routine after a few days of normal sleep.

344 14 replies
@lv2465 2025-10-04

As someone who has lived with insomnia for decade's i learned that my body and mind rest differently for example my body can rest by simply relaxing either sitting or laying flat where my brain rests by cutting out light and just listening to the sounds of the night, i drift off and when i wake i feel rested not groggy and irritable. As a result i no longer worry about how many hour's so long as i get that silent period at night.

229 13 replies
@ThomasDeLauerOfficial 2025-09-29

Here’s a Cortisol Lowering Meal plan that focuses on real, Whole Foods. Totally Free, just my gift to you: http://www.thomasdelauer.com/eatrealfood - consider it a thank you for watching my videos and for subbing to my newsletter!

170 21 replies
@JustinKent1 2025-10-13

Changing the name of my band to Microarousal

124 7 replies
@ultramarinetoo 2025-10-12

Even watching this at 3:59 am, my brain realises that ths is just a commercial.

48
@QiHealing 2025-12-19

I have awakened at 3 for most of my life! I consider it my private time away from my kids, husband and other things. So it is an enormously productive time to get up, have a hot glass of water with a little milk in it, and read, or write, or sew for about an hour. Then I go back to bed refreshed and sleep another few hours. Some nights I stand outside and watch the stars. It is a gift. Don't lie in bed, though, you are wasting this precious time and it will not be productive for you.

9

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