I'm No Longer Insulin Resistant, Here's 12 Things I Did to SHUT IT DOWN Fast
Mastering Insulin Resistance: Inflammation, Mitochondria, and Gut Health Insights
Unlock 15 definitive strategies DeLauer used to overcome severe insulin resistance, moving beyond simple carb restriction to address root inflammatory and mitochondrial drivers.
Short Summary
- Attain insulin sensitivity by controlling systemic inflammation, which is the core driver of IR. [00:00:28]
- Utilize targeted nutritional and lifestyle interventions like Carnosine supplementation and protein preloading to rapidly modulate glucose response. [00:01:19], [00:08:06]
- Recognize that IR is fundamentally a fuel partitioning problem, fixable quickly with practices like Timerestricted Feeding (TRF). [00:12:48], [00:10:13] This overview details DeLauer's hard-won lessons from 13 years managing insulin resistance, focusing on inflammation, muscle signaling, nutrient status, and mitochondrial efficiency. Apply these tactical shifts to regain metabolic function rapidly.
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Top Comments (10)
Here is a detailed point-by-point summary: 1. **Inflammation is the Root Cause:** Insulin resistance is primarily an inflammatory condition. High inflammation blocks the insulin signal, preventing your cells from processing carbohydrates properly. 2. **Use Carnosine to Block Glycation:** Glycation (when sugars bind to proteins/fats) drives oxidative stress and inflammation. Taking 4-6 grams of Carnosine per day blocks this process, reducing foggy feelings and joint pain. 3. **Insulin Resistance Starts in the Muscle:** Muscles are metabolic signaling organs. Resistance training stresses the muscles, creating a feedback loop that helps restore insulin sensitivity. Cardio alone isn't enough. 4. **Fix Nutrient Deficiencies:** Lacking key minerals like calcium can increase appetite and worsen insulin resistance. Getting adequate calcium from sources like healthy dairy (aged cheese, heavy cream) can improve sensitivity and appetite. 5. **Separate Fats and Carbs:** Eating large amounts of fat and carbs together creates a "mitochondrial traffic jam," where your body can't efficiently use either fuel. Separate them in your meals to avoid this. 6. **Induce GLP-1 with Certain Foods:** GLP-1 is a hormone that helps with glucose modulation. Stimulate its production with foods like allulose, high amounts of protein, and soluble fiber. 7. **Heal Your Gut Microbiome:** Your gut bacteria produce short-chain fatty acids that are critical for glucose metabolism. A healthy gut is essential for managing insulin resistance. Probiotics can help. 8. **Leverage the "2nd Meal Effect":** What you eat for breakfast directly impacts your glucose response at lunch. A high-protein, low-glycemic breakfast can improve your lunch glucose response by 30-40%. 9. **I.R., Fatty Liver & Visceral Fat are Linked:** These three conditions create a vicious cycle. Insulin resistance can cause fatty liver, which leads to more visceral fat, which in turn creates more inflammation and worsens insulin resistance. 10. **Address Magnesium Deficiency:** Magnesium is crucial for making your insulin receptors work properly. A deficiency can directly cause insulin resistance symptoms to return. 11. **I.R. Can Be Corrected Fast:** You can see huge improvements in insulin sensitivity in as little as 4-5 days by using time-restricted feeding or intermittent fasting, which gives your pancreas a reset. 12. **Prioritize Sleep Hygiene:** Poor sleep can make you 20-40% more insulin resistant the next day. Improve sleep with supplements like 200-400mg of theanine, 3-5g of glycine, or 20-30mg of saffron extract. 13. **Use Red Light Therapy:** Mitochondria respond to light. Red light therapy helps them function better, improving your body's ability to use fuel (including glucose) for energy. 14. **Consider Methylene Blue:** For those with metabolic dysfunction, methylene blue can act like a "jumper cable" for the mitochondria, helping electrons create energy more efficiently. 15. **Train Your Body to Use Carbs:** Carb intolerance is a *symptom* of insulin resistance, not the cause. If you avoid carbs forever, your body loses the ability to process them. You must strategically train your body to use both fat and carbs as fuel.
I went to a functional medicine NP yesterday. He told me that inflammation is driving my insulin resistance. He blames it on dairy and wheat. I lift weights 3 x week; walk a lot, eat low carbs and no sodas/junk or alcohol. My inflammatory markers were elevated too. So now, I’m going to continue low carbs and cut off the dairy and gluten and see what happens
I’m exhausted from dietary/nutrition information overload.
I got diagnosed type 2 this week and quite frankly there is so much contradictory advice on the subject its hard to know who to believe
This breakdown is gold. Most people think insulin resistance starts in the pancreas — but it’s really a muscle, mitochondria, and inflammation issue. Fix the engine, not just the fuel.
I appreciate how honest and detailed this video is. I’ve been working on reversing insulin resistance myself, and adding strength training plus more sleep made a big impact. Sending positive vibes to everyone here fighting the same battle — we’ve got this!
Walk before your meal. And do a short walk afterwards as well.
I’m in complete overload
Summary- missed about 3 1. Reduce inflammation strategically 2. Take some Carnosine 3. Start exercising your muscles(weight training) 4. You need calcium! 4. Try not to eat large amounts of fats and carbs together...regardless of that your culture has told you. 5. Allulose, soluble fibers, and more protein is good for you. 6. Probiotics is good. Also, just healing your gut microbioms generally 7. What you eat for breakfast is important. High protein, low glycemic carb, high fiber. 8. Sprinting or just short span high intensity excercise, fasting, fermented foods 9. Make sure you get enough Magnesium 10. Get enough good sleep. 11. Red light therapy is a surprising yes.
The real amazing thing is how he managed to make an entire video about insulin resistance and never mention the words 'Diabetes' and 'Diabetes 2'. 😂
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Top Comments (10)
Here is a detailed point-by-point summary: 1. **Inflammation is the Root Cause:** Insulin resistance is primarily an inflammatory condition. High inflammation blocks the insulin signal, preventing your cells from processing carbohydrates properly. 2. **Use Carnosine to Block Glycation:** Glycation (when sugars bind to proteins/fats) drives oxidative stress and inflammation. Taking 4-6 grams of Carnosine per day blocks this process, reducing foggy feelings and joint pain. 3. **Insulin Resistance Starts in the Muscle:** Muscles are metabolic signaling organs. Resistance training stresses the muscles, creating a feedback loop that helps restore insulin sensitivity. Cardio alone isn't enough. 4. **Fix Nutrient Deficiencies:** Lacking key minerals like calcium can increase appetite and worsen insulin resistance. Getting adequate calcium from sources like healthy dairy (aged cheese, heavy cream) can improve sensitivity and appetite. 5. **Separate Fats and Carbs:** Eating large amounts of fat and carbs together creates a "mitochondrial traffic jam," where your body can't efficiently use either fuel. Separate them in your meals to avoid this. 6. **Induce GLP-1 with Certain Foods:** GLP-1 is a hormone that helps with glucose modulation. Stimulate its production with foods like allulose, high amounts of protein, and soluble fiber. 7. **Heal Your Gut Microbiome:** Your gut bacteria produce short-chain fatty acids that are critical for glucose metabolism. A healthy gut is essential for managing insulin resistance. Probiotics can help. 8. **Leverage the "2nd Meal Effect":** What you eat for breakfast directly impacts your glucose response at lunch. A high-protein, low-glycemic breakfast can improve your lunch glucose response by 30-40%. 9. **I.R., Fatty Liver & Visceral Fat are Linked:** These three conditions create a vicious cycle. Insulin resistance can cause fatty liver, which leads to more visceral fat, which in turn creates more inflammation and worsens insulin resistance. 10. **Address Magnesium Deficiency:** Magnesium is crucial for making your insulin receptors work properly. A deficiency can directly cause insulin resistance symptoms to return. 11. **I.R. Can Be Corrected Fast:** You can see huge improvements in insulin sensitivity in as little as 4-5 days by using time-restricted feeding or intermittent fasting, which gives your pancreas a reset. 12. **Prioritize Sleep Hygiene:** Poor sleep can make you 20-40% more insulin resistant the next day. Improve sleep with supplements like 200-400mg of theanine, 3-5g of glycine, or 20-30mg of saffron extract. 13. **Use Red Light Therapy:** Mitochondria respond to light. Red light therapy helps them function better, improving your body's ability to use fuel (including glucose) for energy. 14. **Consider Methylene Blue:** For those with metabolic dysfunction, methylene blue can act like a "jumper cable" for the mitochondria, helping electrons create energy more efficiently. 15. **Train Your Body to Use Carbs:** Carb intolerance is a *symptom* of insulin resistance, not the cause. If you avoid carbs forever, your body loses the ability to process them. You must strategically train your body to use both fat and carbs as fuel.
I went to a functional medicine NP yesterday. He told me that inflammation is driving my insulin resistance. He blames it on dairy and wheat. I lift weights 3 x week; walk a lot, eat low carbs and no sodas/junk or alcohol. My inflammatory markers were elevated too. So now, I’m going to continue low carbs and cut off the dairy and gluten and see what happens
I’m exhausted from dietary/nutrition information overload.
I got diagnosed type 2 this week and quite frankly there is so much contradictory advice on the subject its hard to know who to believe
This breakdown is gold. Most people think insulin resistance starts in the pancreas — but it’s really a muscle, mitochondria, and inflammation issue. Fix the engine, not just the fuel.
I appreciate how honest and detailed this video is. I’ve been working on reversing insulin resistance myself, and adding strength training plus more sleep made a big impact. Sending positive vibes to everyone here fighting the same battle — we’ve got this!
Walk before your meal. And do a short walk afterwards as well.
I’m in complete overload
Summary- missed about 3 1. Reduce inflammation strategically 2. Take some Carnosine 3. Start exercising your muscles(weight training) 4. You need calcium! 4. Try not to eat large amounts of fats and carbs together...regardless of that your culture has told you. 5. Allulose, soluble fibers, and more protein is good for you. 6. Probiotics is good. Also, just healing your gut microbioms generally 7. What you eat for breakfast is important. High protein, low glycemic carb, high fiber. 8. Sprinting or just short span high intensity excercise, fasting, fermented foods 9. Make sure you get enough Magnesium 10. Get enough good sleep. 11. Red light therapy is a surprising yes.
The real amazing thing is how he managed to make an entire video about insulin resistance and never mention the words 'Diabetes' and 'Diabetes 2'. 😂